ID   ENA1_HORSE              Reviewed;          46 AA.
AC   P80930;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Antimicrobial peptide eNAP-1;
DE   Flags: Fragment;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Neutrophil;
RX   PubMed=1639474; DOI=10.1128/iai.60.8.3065-3071.1992;
RA   Couto A.M., Harwig S.S.L., Cullor J.S., Hughes J.P., Lehrer R.I.;
RT   "Identification of eNAP-1, an antimicrobial peptide from equine
RT   neutrophils.";
RL   Infect. Immun. 60:3065-3071(1992).
CC   -!- FUNCTION: Has antimicrobial activity against Gram-negative and Gram-
CC       positive bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the granulin family. {ECO:0000305}.
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DR   PIR; A44794; A44794.
DR   STRING; 9796.ENSECAP00000016112; -.
DR   PaxDb; P80930; -.
DR   PRIDE; P80930; -.
DR   Proteomes; UP000002281; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.25.160; -; 1.
DR   InterPro; IPR000118; Granulin.
DR   InterPro; IPR037277; Granulin_sf.
DR   Pfam; PF00396; Granulin; 1.
DR   SMART; SM00277; GRAN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Disulfide bond;
KW   Reference proteome; Secreted.
FT   CHAIN           1..>46
FT                   /note="Antimicrobial peptide eNAP-1"
FT                   /id="PRO_0000150133"
FT   DISULFID        4..16
FT                   /evidence="ECO:0000250"
FT   DISULFID        10..26
FT                   /evidence="ECO:0000250"
FT   NON_TER         46
SQ   SEQUENCE   46 AA;  4891 MW;  2171934C15265862 CRC64;
     DVQCGEGHFC HDXQTCCRAS QGGXACCPYS QGVCCADQRH CCPVGF