AGAP9_HUMAN
ID AGAP9_HUMAN Reviewed; 703 AA.
AC Q5VTM2; D3YTF3;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9;
DE Short=AGAP-9;
DE AltName: Full=Centaurin-gamma-like family member 6;
GN Name=AGAP9; Synonyms=CTGLF6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative GTPase-activating protein. {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5VTM2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5VTM2-2; Sequence=VSP_044549, VSP_044550, VSP_044551;
CC -!- MISCELLANEOUS: Encoded by one of the numerous copies of centaurin
CC gamma-like genes clustered in the q11 region of chromosome 10.
CC -!- SIMILARITY: Belongs to the centaurin gamma-like family. {ECO:0000305}.
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DR EMBL; AL591684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC171845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS73125.1; -. [Q5VTM2-2]
DR RefSeq; NP_001177739.1; NM_001190810.1. [Q5VTM2-2]
DR AlphaFoldDB; Q5VTM2; -.
DR SMR; Q5VTM2; -.
DR BioGRID; 568033; 1.
DR IntAct; Q5VTM2; 1.
DR GlyGen; Q5VTM2; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q5VTM2; -.
DR PhosphoSitePlus; Q5VTM2; -.
DR BioMuta; AGAP9; -.
DR DMDM; 145558891; -.
DR jPOST; Q5VTM2; -.
DR MassIVE; Q5VTM2; -.
DR PaxDb; Q5VTM2; -.
DR PeptideAtlas; Q5VTM2; -.
DR PRIDE; Q5VTM2; -.
DR Antibodypedia; 67499; 53 antibodies from 9 providers.
DR DNASU; 642517; -.
DR Ensembl; ENST00000452145.6; ENSP00000392206.2; ENSG00000204172.12. [Q5VTM2-2]
DR GeneID; 642517; -.
DR KEGG; hsa:642517; -.
DR MANE-Select; ENST00000452145.6; ENSP00000392206.2; NM_001190810.1; NP_001177739.1. [Q5VTM2-2]
DR UCSC; uc057tbu.1; human. [Q5VTM2-1]
DR CTD; 642517; -.
DR GeneCards; AGAP9; -.
DR HGNC; HGNC:23463; AGAP9.
DR HPA; ENSG00000204172; Low tissue specificity.
DR neXtProt; NX_Q5VTM2; -.
DR OpenTargets; ENSG00000204172; -.
DR VEuPathDB; HostDB:ENSG00000204172; -.
DR GeneTree; ENSGT00940000163475; -.
DR HOGENOM; CLU_392755_0_0_1; -.
DR InParanoid; Q5VTM2; -.
DR OMA; KEWWIRS; -.
DR OrthoDB; 751525at2759; -.
DR PhylomeDB; Q5VTM2; -.
DR TreeFam; TF317762; -.
DR PathwayCommons; Q5VTM2; -.
DR SignaLink; Q5VTM2; -.
DR BioGRID-ORCS; 642517; 33 hits in 629 CRISPR screens.
DR GenomeRNAi; 642517; -.
DR Pharos; Q5VTM2; Tdark.
DR PRO; PR:Q5VTM2; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q5VTM2; protein.
DR Bgee; ENSG00000204172; Expressed in right uterine tube and 93 other tissues.
DR Genevisible; Q5VTM2; HS.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR Gene3D; 1.10.220.150; -; 1.
DR Gene3D; 1.25.40.20; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR Pfam; PF01412; ArfGap; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF57863; SSF57863; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Alternative splicing; ANK repeat; GTPase activation; Metal-binding;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..703
FT /note="Arf-GAP with GTPase, ANK repeat and PH domain-
FT containing protein 9"
FT /id="PRO_0000284677"
FT DOMAIN 327..488
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT DOMAIN 509..629
FT /note="Arf-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT REPEAT 631..700
FT /note="ANK"
FT ZN_FING 524..547
FT /note="C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT REGION 249..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..154
FT /note="MFEDVFSDSGNTGNFDRGKKRRLTIIECGCDINMMIDLAKVADLVLMLIDAS
FT FGFEMEMFEFLNICQAHGFPKILGVLTHLDSFKHNKQLKKTKKRLKHRFWTEVYQDKVG
FT LTHELVQSLISTYSTIDAKMASSRVTLLSNSKPLGSEAIDNQG -> MGNILTCRVHPS
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_044549"
FT VAR_SEQ 216
FT /note="E -> EALEFNLSANPEASTIFQRNSQTDALEFNSSANPEASTIFQRNSQTD
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_044550"
FT VAR_SEQ 229..240
FT /note="CDLGDTSSYHTK -> VSTERFSQQYSSCSTIFLDDSTAIQHYLTMTIISVT
FT LEIPHHITQRDADRSLSIPDEQLHSFA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_044551"
FT CONFLICT 495
FT /note="K -> E (in Ref. 2; BC171845)"
FT /evidence="ECO:0000305"
FT CONFLICT 508
FT /note="E -> K (in Ref. 2; BC171845)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 703 AA; 77972 MW; 28D84F589E15A0EB CRC64;
MFEDVFSDSG NTGNFDRGKK RRLTIIECGC DINMMIDLAK VADLVLMLID ASFGFEMEMF
EFLNICQAHG FPKILGVLTH LDSFKHNKQL KKTKKRLKHR FWTEVYQDKV GLTHELVQSL
ISTYSTIDAK MASSRVTLLS NSKPLGSEAI DNQGVSLEFD QQQGSVCPSE SEIYEAGAED
RMAGAPMAAA VQPAEVTVEV GEDLHMHQVR DREMPEVVEI RRSNCTNHCD LGDTSSYHTK
VSTVHIMKKR NGGGSLNNYS SSIPPTPSTS QEDPQFSVPP TANTPTPVCK RSMRWSNLFT
SEKGSDPDKE RKAPENHADT IGSGRAIPIK QGMLLKRSGK WLKTWKKKYV TLCSNGVLTY
YSSLGDYMKN IHKKEIDLRT STIKVPGKWP SLATSACAPI SSSKSNGLSK DMDTGLGDSI
CFSPGISSTT SPKLNPPPSP HANKKKHLKK KSTNNFMIVS ATGQTWHFEA TTYEERDAWV
QAIQSQILAS LQSCKSSKSK SQLTSQSEAM ALQSIQNMRG NAHCVDCETQ NPKWASLNLG
VLMCIECSGI HRSFGTRLSR VRSLELDDWP VELRKVMSSI GNELANSIWE GSSQGQTKPS
IKSTREEKEW WIRSKYEEKL FLAPLPCTEL SLGQQLLRAT TDEDLQTAIL LLAHGSREEV
NETCGEGDGC TALHLACRKG NVVLEQLLTG WTSWPEMPTG TQR
