ID   ENCAP_RHORT             Reviewed;         280 AA.
AC   Q2RVS0;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Type 1 encapsulin shell protein {ECO:0000303|PubMed:27529188};
GN   Name=enc {ECO:0000305}; OrderedLocusNames=Rru_A0974;
OS   Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 /
OS   NCIMB 8255 / S1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Rhodospirillaceae; Rhodospirillum.
OX   NCBI_TaxID=269796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1;
RX   PubMed=21886856; DOI=10.4056/sigs.1804360;
RA   Munk A.C., Copeland A., Lucas S., Lapidus A., Del Rio T.G., Barry K.,
RA   Detter J.C., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D.,
RA   Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Kyrpides N.C.,
RA   Mavromatis K., Richardson P., Rohde M., Goeker M., Klenk H.P., Zhang Y.,
RA   Roberts G.P., Reslewic S., Schwartz D.C.;
RT   "Complete genome sequence of Rhodospirillum rubrum type strain (S1).";
RL   Stand. Genomic Sci. 4:293-302(2011).
RN   [2]
RP   FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RC   STRAIN=ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1;
RX   PubMed=27529188; DOI=10.7554/elife.18972;
RA   He D., Hughes S., Vanden-Hehir S., Georgiev A., Altenbach K., Tarrant E.,
RA   Mackay C.L., Waldron K.J., Clarke D.J., Marles-Wright J.;
RT   "Structural characterization of encapsulated ferritin provides insight into
RT   iron storage in bacterial nanocompartments.";
RL   Elife 5:0-0(2016).
RN   [3]
RP   FUNCTION.
RC   STRAIN=ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1;
RX   PubMed=32878987; DOI=10.1074/jbc.ra120.014502;
RA   Piergentili C., Ross J., He D., Gallagher K.J., Stanley W.A., Adam L.,
RA   Mackay C.L., Basle A., Waldron K.J., Clarke D.J., Marles-Wright J.;
RT   "Dissecting the structural and functional roles of a putative metal entry
RT   site in encapsulated ferritins.";
RL   J. Biol. Chem. 295:15511-15526(2020).
RN   [4]
RP   CLASSIFICATION.
RX   PubMed=34362927; DOI=10.1038/s41467-021-25071-y;
RA   Andreas M.P., Giessen T.W.;
RT   "Large-scale computational discovery and analysis of virus-derived
RT   microbial nanocompartments.";
RL   Nat. Commun. 12:4748-4748(2021).
CC   -!- FUNCTION: Shell component of a type 1 encapsulin nanocompartment.
CC       Assembles into proteinaceous icosahedral shells 24 nm in diameter in
CC       the presence and absence of its ferritin cargo protein. The center of
CC       cargo-loaded nanocompartments is loaded with iron. The empty encapsulin
CC       nanocompartment sequesters about 2200 Fe ions while the cargo-loaded
CC       nanocompartment can maximally sequester about 4150 Fe ions. Does not
CC       have any detectable ferroxidase activity. {ECO:0000269|PubMed:27529188,
CC       ECO:0000269|PubMed:32878987}.
CC   -!- SUBUNIT: This encapsulin nanocompartment is formed by 60 subunits;
CC       monomers form pentamers which assemble to form shells. There are 12
CC       pores where the pentamers meet as well as 3-fold axis channels and
CC       dimer channels; none are larger than 3-4 Angstroms in diameter. The N-
CC       terminus of the protein is inside the shell, the C-terminus is outside.
CC       {ECO:0000250|UniProtKB:Q9WZP2, ECO:0000305|PubMed:27529188}.
CC   -!- SUBCELLULAR LOCATION: Encapsulin nanocompartment
CC       {ECO:0000269|PubMed:27529188}.
CC   -!- SIMILARITY: Belongs to the encapsulin family. Family 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CP000230; ABC21775.1; -; Genomic_DNA.
DR   RefSeq; WP_011388729.1; NC_007643.1.
DR   RefSeq; YP_426062.1; NC_007643.1.
DR   STRING; 269796.Rru_A0974; -.
DR   MEROPS; U56.001; -.
DR   EnsemblBacteria; ABC21775; ABC21775; Rru_A0974.
DR   KEGG; rru:Rru_A0974; -.
DR   PATRIC; fig|269796.9.peg.1029; -.
DR   eggNOG; COG1659; Bacteria.
DR   HOGENOM; CLU_089875_1_0_5; -.
DR   OMA; DSDWQPV; -.
DR   OrthoDB; 1252793at2; -.
DR   Proteomes; UP000001929; Chromosome.
DR   GO; GO:0140737; C:encapsulin nanocompartment; IDA:UniProtKB.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR007544; Linocin_M18.
DR   Pfam; PF04454; Linocin_M18; 1.
DR   PIRSF; PIRSF019254; CFP29; 1.
PE   1: Evidence at protein level;
KW   Encapsulin nanocompartment; Ion transport; Iron; Iron storage;
KW   Iron transport; Reference proteome; Transport.
FT   CHAIN           1..280
FT                   /note="Type 1 encapsulin shell protein"
FT                   /id="PRO_0000455318"
SQ   SEQUENCE   280 AA;  29733 MW;  1E8F51374A2DCB15 CRC64;
     MNDLMRDLAP ISAKAWAEIE TEARGTLTVT LAARKVVDFK GPLGWDASSV SLGRTEALAE
     EPKAAGSAAV VTVRKRAVQP LIELCVPFTL KRAELEAIAR GASDADLDPV IEAARAIAIA
     EDRAVFHGFA AGGITGIGEA SAEHALDLPA DLADFPGVLV RALAVLRDRG VDGPYALVLG
     RTVYQQLMET TTPGGYPVLQ HVRRLFEGPL IWAPGVDGAM LISQRGGDFE LTVGRDFSIG
     YHDHDAQSVH LYLQESMTFR CLGPEAAVPL RGLSQAATKA