ID   AGAR_ECOLI              Reviewed;         269 AA.
AC   P0ACK2; P42902; Q2M978;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Putative aga operon transcriptional repressor;
GN   Name=agaR; Synonyms=yhaW; OrderedLocusNames=b3131, JW3100;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C;
RX   PubMed=10931310; DOI=10.1046/j.1365-2958.2000.01969.x;
RA   Brinkkoetter A., Kloess H., Alpert C.-A., Lengeler J.W.;
RT   "Pathways for the utilization of N-acetyl-galactosamine and galactosamine
RT   in Escherichia coli.";
RL   Mol. Microbiol. 37:125-135(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   DISCUSSION OF SEQUENCE.
RX   PubMed=8932697; DOI=10.1099/13500872-142-2-231;
RA   Reizer J., Ramseier T.M., Reizer A., Charbit A., Saier M.H. Jr.;
RT   "Novel phosphotransferase genes revealed by bacterial genome sequencing: a
RT   gene cluster encoding a putative N-acetylgalactosamine metabolic pathway in
RT   Escherichia coli.";
RL   Microbiology 142:231-250(1996).
CC   -!- FUNCTION: Probable repressor for the aga operon for N-acetyl
CC       galactosamine transport and metabolism.
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DR   EMBL; AF228498; AAF81081.1; -; Genomic_DNA.
DR   EMBL; U18997; AAA57934.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76165.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77178.1; -; Genomic_DNA.
DR   PIR; G65102; G65102.
DR   RefSeq; NP_417600.1; NC_000913.3.
DR   RefSeq; WP_000072187.1; NZ_STEB01000001.1.
DR   AlphaFoldDB; P0ACK2; -.
DR   SMR; P0ACK2; -.
DR   BioGRID; 4262414; 8.
DR   DIP; DIP-48095N; -.
DR   IntAct; P0ACK2; 4.
DR   STRING; 511145.b3131; -.
DR   jPOST; P0ACK2; -.
DR   PaxDb; P0ACK2; -.
DR   PRIDE; P0ACK2; -.
DR   DNASU; 947636; -.
DR   EnsemblBacteria; AAC76165; AAC76165; b3131.
DR   EnsemblBacteria; BAE77178; BAE77178; BAE77178.
DR   GeneID; 66672970; -.
DR   GeneID; 947636; -.
DR   KEGG; ecj:JW3100; -.
DR   KEGG; eco:b3131; -.
DR   PATRIC; fig|1411691.4.peg.3600; -.
DR   EchoBASE; EB2615; -.
DR   eggNOG; COG1349; Bacteria.
DR   HOGENOM; CLU_060699_3_1_6; -.
DR   InParanoid; P0ACK2; -.
DR   OMA; FDNDVTR; -.
DR   PhylomeDB; P0ACK2; -.
DR   BioCyc; EcoCyc:G7630-MON; -.
DR   PRO; PR:P0ACK2; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IDA:EcoCyc.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:EcoCyc.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR014036; DeoR_C.
DR   InterPro; IPR001034; DeoR_HTH.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR018356; Tscrpt_reg_HTH_DeoR_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00455; DeoRC; 1.
DR   Pfam; PF08220; HTH_DeoR; 1.
DR   SMART; SM00420; HTH_DEOR; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00894; HTH_DEOR_1; 1.
DR   PROSITE; PS51000; HTH_DEOR_2; 1.
PE   4: Predicted;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..269
FT                   /note="Putative aga operon transcriptional repressor"
FT                   /id="PRO_0000050241"
FT   DOMAIN          15..70
FT                   /note="HTH deoR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
FT   DNA_BIND        32..51
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
SQ   SEQUENCE   269 AA;  29572 MW;  73B5C19B357AE014 CRC64;
     MSNTDASGEK RVTGTSERRE QIIQRLRQQG SVQVNDLSAL YGVSTVTIRN DLAFLEKQGI
     AVRAYGGALI CDSTTPSVEP SVEDKSALNT AMKRSVAKAA VELIQPGHRV ILDSGTTTFE
     IARLMRKHTD VIAMTNGMNV ANALLEAEGV ELLMTGGHLR RQSQSFYGDQ AEQSLQNYHF
     DMLFLGVDAI DLERGVSTHN EDEARLNRRM CEVAERIIVV TDSSKFNRSS LHKIIDTQRI
     DMIIVDEGIP ADSLEGLRKA GVEVILVGE