位置:首页 > 蛋白库 > ENCC_ASPFU
ENCC_ASPFU
ID   ENCC_ASPFU              Reviewed;         181 AA.
AC   A4DA85;
DT   07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Anthrone oxygenase encC {ECO:0000303|PubMed:22492455};
DE            EC=1.-.-.- {ECO:0000305|PubMed:22492455};
DE   AltName: Full=Endocrocin synthesis protein C {ECO:0000303|PubMed:22492455};
GN   Name=encC {ECO:0000303|PubMed:22492455}; ORFNames=AFUA_4G00225;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
RN   [2]
RP   BIOTECHNOLOGY.
RX   PubMed=20379952; DOI=10.1055/s-0030-1249779;
RA   Gautam R., Karkhile K.V., Bhutani K.K., Jachak S.M.;
RT   "Anti-inflammatory, cyclooxygenase (COX)-2, COX-1 inhibitory, and free
RT   radical scavenging effects of Rumex nepalensis.";
RL   Planta Med. 76:1564-1569(2010).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=22492455; DOI=10.1128/aem.07710-11;
RA   Lim F.Y., Hou Y., Chen Y., Oh J.H., Lee I., Bugni T.S., Keller N.P.;
RT   "Genome-based cluster deletion reveals an endocrocin biosynthetic pathway
RT   in Aspergillus fumigatus.";
RL   Appl. Environ. Microbiol. 78:4117-4125(2012).
RN   [4]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=23592999; DOI=10.1371/journal.ppat.1003289;
RA   Berthier E., Lim F.Y., Deng Q., Guo C.J., Kontoyiannis D.P., Wang C.C.,
RA   Rindy J., Beebe D.J., Huttenlocher A., Keller N.P.;
RT   "Low-volume toolbox for the discovery of immunosuppressive fungal secondary
RT   metabolites.";
RL   PLoS Pathog. 9:E1003289-E1003289(2013).
RN   [5]
RP   INDUCTION.
RX   PubMed=26242966; DOI=10.1111/1462-2920.13007;
RA   Throckmorton K., Lim F.Y., Kontoyiannis D.P., Zheng W., Keller N.P.;
RT   "Redundant synthesis of a conidial polyketide by two distinct secondary
RT   metabolite clusters in Aspergillus fumigatus.";
RL   Environ. Microbiol. 18:246-259(2016).
CC   -!- FUNCTION: Anthrone oxygenase; part of the gene cluster that mediates
CC       the biosynthesis of endocrocin, a simple anthraquinone interesting for
CC       many biotechnological applications (PubMed:22492455, PubMed:23592999).
CC       The pathway begins with the synthesis of atrochrysone thioester by the
CC       polyketide synthase (PKS) encA (PubMed:22492455). The atrochrysone
CC       carboxyl ACP thioesterase encB then breaks the thioester bond and
CC       releases the atrochrysone carboxylic acid from encA (PubMed:22492455).
CC       The atrochrysone carboxylic acid is then converted to endocrocin
CC       anthrone which is further oxidized into endocrocin by the anthrone
CC       oxygenase encC (PubMed:22492455). The exact function of encD has not
CC       been identified yet, but it negatively regulates endocrocin production,
CC       likely through the modification of endocrocin itself (PubMed:22492455).
CC       {ECO:0000269|PubMed:22492455, ECO:0000269|PubMed:23592999}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Endocrocin is specifically produced in conidia.
CC       {ECO:0000305|PubMed:23592999}.
CC   -!- INDUCTION: Expression is positively regulated by the transcription
CC       factors brlA and laeA (PubMed:26242966). {ECO:0000269|PubMed:26242966}.
CC   -!- DISRUPTION PHENOTYPE: Leads to unstable anthrone production and
CC       abolishes the production of endocrocin (PubMed:22492455).
CC       {ECO:0000269|PubMed:22492455}.
CC   -!- BIOTECHNOLOGY: Endocrocin and related anthraquinones compounds have
CC       interesting activities for medicinal uses, including anti-inflammatory
CC       activity (PubMed:20379952). {ECO:0000269|PubMed:20379952}.
CC   -!- SIMILARITY: Belongs to the anthrone oxygenase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAHF01000017; EBA27176.1; -; Genomic_DNA.
DR   RefSeq; XP_001481526.1; XM_001481476.1.
DR   AlphaFoldDB; A4DA85; -.
DR   STRING; 746128.CADAFUBP00009782; -.
DR   EnsemblFungi; EBA27176; EBA27176; AFUA_4G00225.
DR   GeneID; 5077074; -.
DR   KEGG; afm:AFUA_4G00225; -.
DR   VEuPathDB; FungiDB:Afu4g00225; -.
DR   eggNOG; ENOG502SBMN; Eukaryota.
DR   HOGENOM; CLU_105974_1_0_1; -.
DR   InParanoid; A4DA85; -.
DR   OMA; WASGFIA; -.
DR   OrthoDB; 1517224at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:1900602; P:endocrocin biosynthetic process; IMP:AspGD.
PE   1: Evidence at protein level;
KW   Membrane; Monooxygenase; Oxidoreductase; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..181
FT                   /note="Anthrone oxygenase encC"
FT                   /id="PRO_0000437095"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   181 AA;  19473 MW;  D69FD4D3CB2FA797 CRC64;
     MASVQGLIKI VAITGGVWLS GKITAHSLVS VPALLQTRSA DGLSPCTILR VWRRIYEQGH
     RHSPQIAACT STAFAYLAWC ASDRTPRLLY GTAACSVMGI VPYTLLFMGP TNSRLLERSA
     AEEEKVPGAT RGEDMVNVPS EMTTEELLSH WRFLAGIRGL LPLAGGILGL FAALYSNEGA
     R
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024