ID   ENCP1_MYCPA             Reviewed;         265 AA.
AC   Q743F5;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Type 1 encapsulin shell protein;
GN   Name=enc1 {ECO:0000305}; OrderedLocusNames=MAP_0630c;
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10;
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH DYP, SUBUNIT,
RP   SUBCELLULAR LOCATION, AND ANTIGENICITY.
RC   STRAIN=509;
RX   PubMed=25500374; DOI=10.1016/j.vetmic.2014.11.009;
RA   Leite F.L., Reinhardt T.A., Bannantine J.P., Stabel J.R.;
RT   "Envelope protein complexes of Mycobacterium avium subsp. paratuberculosis
RT   and their antigenicity.";
RL   Vet. Microbiol. 175:275-285(2015).
RN   [3]
RP   CLASSIFICATION.
RX   PubMed=34362927; DOI=10.1038/s41467-021-25071-y;
RA   Andreas M.P., Giessen T.W.;
RT   "Large-scale computational discovery and analysis of virus-derived
RT   microbial nanocompartments.";
RL   Nat. Commun. 12:4748-4748(2021).
CC   -!- FUNCTION: Shell component of a type 1 encapsulin nanocompartment.
CC       Assembles into proteinaceous shells 23-24 nm in diameter with 2-2.5 nm
CC       thick walls. Cargo protein DyP is targeted to the interior via its C-
CC       terminal extension; probably only 1 DyP hexamer is incorporated into
CC       each shell (By similarity). Probably involved in protection against
CC       oxidative damage (By similarity). {ECO:0000250|UniProtKB:I6WZG6,
CC       ECO:0000250|UniProtKB:Q45296}.
CC   -!- SUBUNIT: Found in a complex with DyP, suggesting it is the native cargo
CC       protein (PubMed:25500374). Monomers form pentamers, which assemble to
CC       form hollow shells composed of 60 subunits with several openings (By
CC       similarity). {ECO:0000250|UniProtKB:Q9WZP2,
CC       ECO:0000269|PubMed:25500374}.
CC   -!- SUBCELLULAR LOCATION: Encapsulin nanocompartment
CC       {ECO:0000250|UniProtKB:Q45296}. Cell membrane
CC       {ECO:0000305|PubMed:25500374}.
CC   -!- SIMILARITY: Belongs to the encapsulin family. Family 1 subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016958; AAS02947.1; -; Genomic_DNA.
DR   RefSeq; WP_003875791.1; NC_002944.2.
DR   STRING; 262316.MAP_0630c; -.
DR   MEROPS; U56.001; -.
DR   EnsemblBacteria; AAS02947; AAS02947; MAP_0630c.
DR   GeneID; 61325310; -.
DR   KEGG; mpa:MAP_0630c; -.
DR   eggNOG; COG1659; Bacteria.
DR   HOGENOM; CLU_089875_1_0_11; -.
DR   OMA; DSDWQPV; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007544; Linocin_M18.
DR   Pfam; PF04454; Linocin_M18; 1.
DR   PIRSF; PIRSF019254; CFP29; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Encapsulin nanocompartment; Membrane; Reference proteome.
FT   CHAIN           1..265
FT                   /note="Type 1 encapsulin shell protein"
FT                   /id="PRO_0000455312"
SQ   SEQUENCE   265 AA;  28618 MW;  6157F708A7DC98C9 CRC64;
     MNNLYRDLAP VTEAAWGEIE LEASRTFKRH VAGRRVVDVS EPGGPAAAAV STGRLIDVEA
     PTNGVVAHLR ASKPLVRLRV PFTLSRYEID NVERGANDSD WDPVKEAAKK LAFVEDRAIF
     EGYAAASIDG IRSASSNKPL ALPADPREIP DVITQAISEL RLAGVDGPYS VLLSADVYTK
     VSETTEHGYP ILEHIDRLVP GDIIWAPAID GAFVLTTRGG DFDLQLGTDV SIGYTSHDAD
     TVQLYLQETL TFLCYTAEAA VPLTS