ID   ENCP2_MYCAV             Reviewed;         307 AA.
AC   Q48899;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Type 2A encapsulin shell protein {ECO:0000250|UniProtKB:Q55032};
DE   AltName: Full=35 kDa antigen {ECO:0000303|PubMed:9596734};
DE   AltName: Full=Major membrane protein 1;
DE   AltName: Full=Major membrane protein I;
DE            Short=MMP-I {ECO:0000303|PubMed:9596734};
GN   Name=enc {ECO:0000305}; Synonyms=mmpI;
OS   Mycobacterium avium.
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=1764;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], ANTIGENICITY, AND SUBUNIT.
RC   STRAIN=IS94;
RX   PubMed=9596734; DOI=10.1128/iai.66.6.2684-2690.1998;
RA   Triccas J.A., Winter N., Roche P.W., Gilpin A., Kendrick K.E.,
RA   Britton W.J.;
RT   "Molecular and immunological analyses of the Mycobacterium avium homolog of
RT   the immunodominant Mycobacterium leprae 35-kilodalton protein.";
RL   Infect. Immun. 66:2684-2690(1998).
RN   [2]
RP   CLASSIFICATION.
RX   PubMed=34362927; DOI=10.1038/s41467-021-25071-y;
RA   Andreas M.P., Giessen T.W.;
RT   "Large-scale computational discovery and analysis of virus-derived
RT   microbial nanocompartments.";
RL   Nat. Commun. 12:4748-4748(2021).
CC   -!- FUNCTION: Shell component of a type 2A encapsulin nanocompartment.
CC       Forms encapsulin nanocompartments about 24 nm in diameter from 60
CC       monomers. Probably encapsulates at least cysteine desulfurase (CyD) and
CC       allows passage of cysteine into its interior, probably involved in
CC       sulfur metabolism. {ECO:0000250|UniProtKB:Q55032}.
CC   -!- SUBUNIT: Homooligomeric (PubMed:9596734). The encapsulin
CC       nanocompartment is formed by 60 subunits; monomers form pentamers which
CC       assemble to form shells. There are 12 charged pores where the pentamers
CC       meet as well as 3-fold axis channels and dimer channels (By
CC       similarity). {ECO:0000250|UniProtKB:Q55032,
CC       ECO:0000269|PubMed:9596734}.
CC   -!- SUBCELLULAR LOCATION: Encapsulin nanocompartment
CC       {ECO:0000250|UniProtKB:Q55032}.
CC   -!- DOMAIN: Has 4 domains; an N-terminal arm not found in the type 1
CC       subfamily, a discontinuous peripheral domain (P), an elongated loop (E)
CC       and the discontinuous axial domain (A). {ECO:0000250|UniProtKB:Q55032}.
CC   -!- MISCELLANEOUS: Dominant antigen for this bacteria, could possibly used
CC       in vaccine formulation and/or for diagnosis.
CC       {ECO:0000269|PubMed:9596734}.
CC   -!- SIMILARITY: Belongs to the encapsulin family. Family 2A subfamily.
CC       {ECO:0000305}.
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DR   EMBL; U43835; AAC18618.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q48899; -.
DR   SMR; Q48899; -.
DR   GO; GO:0140737; C:encapsulin nanocompartment; IC:UniProtKB.
DR   InterPro; IPR045641; MmpI-like_C.
DR   Pfam; PF19307; PCLP; 1.
PE   1: Evidence at protein level;
KW   Encapsulin nanocompartment.
FT   CHAIN           1..307
FT                   /note="Type 2A encapsulin shell protein"
FT                   /id="PRO_0000096511"
SQ   SEQUENCE   307 AA;  33698 MW;  A0211F5FC8507318 CRC64;
     MTSAQNESQA LGDLAARQLA NATKTVPQLS TITPRWLLHL LNWVPVEAGI YRVNRVVNPE
     QVAIKAEAGA GSEEPVPQTY VDYETSPREY TLRSISTLVD IHTRVSDLYS SPHDQIAQQL
     RLTIETIKER QELELINSPE YGLLAQATGR QTIQTLAGAP TPDDLDALIT KVWKTPSFFL
     THPLGIAAFG REATYRGVPP PVVSLFGPTQ FITWHGIRLP SDKVPVEDGK TKFILVRTGE
     ERQGVVGLFQ PGLVGEQAPG LSVRFTGINQ SAIATYLVTL YTSLAVLTDD ALAVLDDVAV
     DQFHEYK