ENC_DROME
ID ENC_DROME Reviewed; 1818 AA.
AC Q8MSX1; A8JNK0; B6IDK9; Q5BIH9; Q7KV61; Q9NGQ6; Q9VZM1;
DT 02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 02-FEB-2004, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Protein encore;
GN Name=enc; ORFNames=CG10847;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=11044391; DOI=10.1242/dev.127.22.4753;
RA Van Buskirk C., Hawkins N.C., Schuepbach T.;
RT "Encore is a member of a novel family of proteins and affects multiple
RT processes in Drosophila oogenesis.";
RL Development 127:4753-4762(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Booth B., Carlson J.W., Chavez C., Frise E., George R.A.,
RA Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1191-1818 (ISOFORM B).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP FUNCTION.
RX PubMed=9428416; DOI=10.1242/dev.124.23.4801;
RA Hawkins N.C., Van Buskirk C., Grossniklaus U., Schuepbach T.;
RT "Post-transcriptional regulation of gurken by encore is required for axis
RT determination in Drosophila.";
RL Development 124:4801-4810(1997).
RN [7]
RP INTERACTION WITH HFP.
RX PubMed=11879639; DOI=10.1016/s1534-5807(02)00128-4;
RA Van Buskirk C., Schuepbach T.;
RT "Half pint regulates alternative splice site selection in Drosophila.";
RL Dev. Cell 2:343-353(2002).
RN [8]
RP FUNCTION, AND INTERACTION WITH CYCE; CUL1 AND THE SCF-PROTEASOME COMPLEX.
RX PubMed=14623823; DOI=10.1242/dev.00855;
RA Ohlmeyer J.T., Schuepbach T.;
RT "Encore facilitates SCF-Ubiquitin-proteasome-dependent proteolysis during
RT Drosophila oogenesis.";
RL Development 130:6339-6349(2003).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267; SER-270; SER-336 AND
RP SER-535, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Required for the regulation of germline mitosis, karyosome
CC formation, and establishment of dorsoventral (DS) polarity of the egg
CC and embryo. Involved in proper grk mRNA localization and translation in
CC the oocyte. May control germline mitosis by facilitating the cyclin E
CC (CycE) proteolysis by the SCF-ubiquitin-proteasome complex.
CC {ECO:0000269|PubMed:14623823, ECO:0000269|PubMed:9428416}.
CC -!- SUBUNIT: Interacts with hfp; however, given the nuclear localization of
CC hfp, the relevance of such interaction is unclear. Interacts with CycE,
CC Cul1, and the SCF-proteasome complex. {ECO:0000269|PubMed:11879639,
CC ECO:0000269|PubMed:14623823}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Note=Colocalizes with grk.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=B; Synonyms=D;
CC IsoId=Q8MSX1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8MSX1-2; Sequence=VSP_009327;
CC Name=A;
CC IsoId=Q8MSX1-3; Sequence=VSP_032690;
CC -!- TISSUE SPECIFICITY: Expressed in all germline cells of the germarium
CC including the stem cells and dividing cystocytes.
CC -!- DEVELOPMENTAL STAGE: In the germarium, it begins to accumulate
CC preferentially within the future oocyte shortly after formation of the
CC 16-cell cyst. In midoogenesis, it can be seen transiently at the
CC posterior edge of the oocyte, but by stage 9 assumes an anterior
CC localization, and appears to be more concentrated at the dorsal side of
CC the oocyte, above the oocyte nucleus. This pattern of localization is
CC similar to that seen for grk mRNA and protein, though not tightly
CC restricted to the dorsal side.
CC -!- MISCELLANEOUS: [Isoform 2]: Splicing donor and acceptor sites between
CC exon 10 and exon 11 are not canonical. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-143 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF68440.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAM49887.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF243382; AAF68440.1; ALT_INIT; mRNA.
DR EMBL; AE014296; AAF47799.2; -; Genomic_DNA.
DR EMBL; AE014296; AAS64963.1; -; Genomic_DNA.
DR EMBL; AE014296; ABW08455.1; -; Genomic_DNA.
DR EMBL; BT021245; AAX33393.1; -; mRNA.
DR EMBL; BT050449; ACJ13156.1; -; mRNA.
DR EMBL; AY118518; AAM49887.1; ALT_INIT; mRNA.
DR RefSeq; NP_001097496.1; NM_001104026.2. [Q8MSX1-1]
DR RefSeq; NP_524765.2; NM_080026.3. [Q8MSX1-1]
DR RefSeq; NP_995992.1; NM_206270.2. [Q8MSX1-3]
DR AlphaFoldDB; Q8MSX1; -.
DR SMR; Q8MSX1; -.
DR BioGRID; 69121; 31.
DR IntAct; Q8MSX1; 2.
DR STRING; 7227.FBpp0305410; -.
DR iPTMnet; Q8MSX1; -.
DR PaxDb; Q8MSX1; -.
DR EnsemblMetazoa; FBtr0073152; FBpp0073011; FBgn0004875. [Q8MSX1-1]
DR EnsemblMetazoa; FBtr0073153; FBpp0089267; FBgn0004875. [Q8MSX1-3]
DR EnsemblMetazoa; FBtr0112844; FBpp0111757; FBgn0004875. [Q8MSX1-1]
DR GeneID; 44543; -.
DR KEGG; dme:Dmel_CG10847; -.
DR UCSC; CG10847-RA; d. melanogaster. [Q8MSX1-1]
DR CTD; 104374; -.
DR FlyBase; FBgn0004875; enc.
DR VEuPathDB; VectorBase:FBgn0004875; -.
DR eggNOG; KOG2953; Eukaryota.
DR GeneTree; ENSGT00940000168363; -.
DR InParanoid; Q8MSX1; -.
DR SignaLink; Q8MSX1; -.
DR BioGRID-ORCS; 44543; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 44543; -.
DR PRO; PR:Q8MSX1; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0004875; Expressed in brain and 22 other tissues.
DR ExpressionAtlas; Q8MSX1; baseline and differential.
DR Genevisible; Q8MSX1; DM.
DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0007282; P:cystoblast division; IMP:FlyBase.
DR GO; GO:0048134; P:germ-line cyst formation; TAS:FlyBase.
DR GO; GO:0007293; P:germarium-derived egg chamber formation; IMP:FlyBase.
DR GO; GO:0007294; P:germarium-derived oocyte fate determination; IMP:FlyBase.
DR GO; GO:0007310; P:oocyte dorsal/ventral axis specification; TAS:FlyBase.
DR GO; GO:0030717; P:oocyte karyosome formation; TAS:FlyBase.
DR GO; GO:0048477; P:oogenesis; IMP:FlyBase.
DR GO; GO:0007317; P:regulation of pole plasm oskar mRNA localization; TAS:FlyBase.
DR Gene3D; 3.30.1370.50; -; 1.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR024771; SUZ.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF12752; SUZ; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF82708; SSF82708; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS51673; SUZ; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Developmental protein; Differentiation;
KW Oogenesis; Phosphoprotein; Reference proteome.
FT CHAIN 1..1818
FT /note="Protein encore"
FT /id="PRO_0000086973"
FT DOMAIN 444..508
FT /note="R3H"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00382"
FT DOMAIN 510..576
FT /note="SUZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01009"
FT REGION 47..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 123..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 885..916
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 936..959
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1176..1249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1332..1648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1684..1709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..354
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..916
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1176..1234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1344..1359
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1376..1390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1400..1446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1489..1521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1577..1631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 267
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 270
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 336
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 535
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT VAR_SEQ 414
FT /note="R -> RVFHQS (in isoform A)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_032690"
FT VAR_SEQ 1612..1800
FT /note="SNNSPNSIVGSQSNSAANTPNAAAPPPPQPQPTLVSHSGGFVVLDQTTGAAM
FT NASPPSLYGGGGGPNAGISGGAGASGAAGSNGGHQPGGGGGARSHIPTAQLHHSAAAAA
FT AAAAGSQQATAAVLSGVAAAAALGGYNPNGASGVYFKYGQTYFAHPSVALPNSRRSPSN
FT DIRPQMAQVAGMYPTMMIQ -> GYNPNGASGVYFKYGQTYFAHPSVALPNSRRSPSND
FT IRPQMAQVAGMYPTMMIQANDLHASLP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11044391"
FT /id="VSP_009327"
FT CONFLICT 118
FT /note="G -> A (in Ref. 1; AAF68440)"
FT /evidence="ECO:0000305"
FT CONFLICT 220..221
FT /note="Missing (in Ref. 1; AAF68440)"
FT /evidence="ECO:0000305"
FT CONFLICT 251..252
FT /note="KL -> NV (in Ref. 1; AAF68440)"
FT /evidence="ECO:0000305"
FT CONFLICT 308
FT /note="F -> Y (in Ref. 1; AAF68440)"
FT /evidence="ECO:0000305"
FT CONFLICT 577
FT /note="G -> D (in Ref. 1; AAF68440)"
FT /evidence="ECO:0000305"
FT CONFLICT 580
FT /note="D -> E (in Ref. 1; AAF68440)"
FT /evidence="ECO:0000305"
FT CONFLICT 709
FT /note="A -> G (in Ref. 1; AAF68440)"
FT /evidence="ECO:0000305"
FT CONFLICT 882
FT /note="G -> A (in Ref. 1; AAF68440)"
FT /evidence="ECO:0000305"
FT CONFLICT 1044
FT /note="I -> V (in Ref. 1; AAF68440)"
FT /evidence="ECO:0000305"
FT CONFLICT 1105
FT /note="A -> T (in Ref. 1; AAF68440)"
FT /evidence="ECO:0000305"
FT CONFLICT 1523
FT /note="P -> Q (in Ref. 1; AAF68440)"
FT /evidence="ECO:0000305"
FT CONFLICT 1761
FT /note="G -> V (in Ref. 4; AAX33393)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1818 AA; 188663 MW; 195C6C1333F5508A CRC64;
MSSTKSQVAL ATNIPTNLSS AASASTAAAA AAVVVVASAN AAVASSANSS GVGSGSGPGP
GSGAGVSGPV AAGTATAVAT GSTVTAATSV AATTSTSVAT ISTSCSSSSI NNINNNCGEE
CQSAAGSSNL GRQNSFGNRR GNMKGKHLTR SHAMRESTSP PRTPTPRAAS EQQQQQLQGE
QHEHNNNNNI NSSSKAQSAG RGNSPLMETP AVIVTSQQPQ QQQQQQQQQQ QSVPPKPQQN
VPLSNEAEFP KLSPPKKSGG QHNRTNSNGS GMEFNNNNNS SNKKFVVDMK ANGLDNKPHN
NSSTGVIFNS GMNYKAAERH DRHERHEMSS QNSNLSNNHD EEPYHYEPRG GGGGKKHRAN
TNAKGNKPRL KNLGGSSSGS IDLGGGGGNG NCNNMSNNGQ SNNSSNNTSG FISRENSSEQ
YTDYGGTDLL VFFRDTLNKN PKDRNILLKI EKDLIDFVQE NSRGCEYRFP PASSYNRMLI
HRTAAFFGME HNVDTETQQC VIVAVAKNTR IPEIRFQSLV RDDARKSILK RDTHSFDEVR
QSPYLCPLSL DRKAKSFEER EEDYDRARSR IFSRTGGNHD GYSGGGGDEE CYGGWEQQQQ
QQKQSQPPRP KRPNGKMLQM QNSTESRDGM RSGGAVPKSH NFGNYGGPPS SGGPGNNSLP
RGDSTNSIKS GRGGFVKQDS TGSTPWRLSP SSSGSIYHYD PSNLPPNQAL QHSGNQYQSQ
NQGNSSSGGY NNYRKSSPHQ QQQSQQQQQS QQHHQQQLQQ PQQLHQQSSQ QYATTELSCS
STESYAEEEA QSPGMECSEG YESYEQQSLP VQQQLSGNGD SASTKGDDCD SLASATACLS
ITTSTSTKNY DRIEVQKYKN QATSPNIPAC CAVGEKLELE AGLPQEQEQE PMAGPSSSGS
ATSSVGITEL PSSQTPLPMV NQVNCDLQSV SPSTTPYSQC EVKTPSQNHA PSAAVEEPKT
TTWTYTQSYQ APDGSTVFHT TTTPNGAAPY CATTYQQGPD GSIYAVPQGM VYAAYPQPGV
GTAGGASQPL FQLTTSSHPP AQTIFASPEA GAEIPGGTYM IPVFDPAQQP REGLIPAQAI
YQTGPGGPGA TTVMPMATAA AYPTAQFATA APNGAPIYQA PLIYSSEPGG GAQLQQLPMA
PYPIQYSYPY YHPISYYVPQ QAVAAAPMVA SQPQVGQAPM QQQAPHTGAG TTTGPPTVVS
VSGQQHHQPH QQHHQQQQHS SNGSVVTSSA YGTRVKRTPG GGSIHYNPSY TPSSVAHAGG
AHHPSAGSAQ IIAAPAASTT TYHALPTLTL AHGGPATGTD LSGAGGAHVY ALPAQHALIP
TNIFPYAAAA AAAAGGPGGP PTTPQVVQQA PPPPPQSAPH HALITAAPFY PANGGNMDQG
ASQSAPSTPA APGRQAPLFS TPPAPNNGSS GSSSAGGGGN SGGYHSNSST PHYYQGQNSN
EGYTSPYEKR NHGGGASGAH SVGVRKPYHP GGYNPRHSVP LGGIPSGAKT PLLNSNNEPT
PRASPSSVSL GGASSSGGAN SYPHRGPPPH TMGVKRDNKP NQLPLISGPP PSYAANSSPG
VSSYESKPPV RLNAGAASFR SQKSMNQDYR RSVSQRNSPS ANGGGSGSHE SSNNSPNSIV
GSQSNSAANT PNAAAPPPPQ PQPTLVSHSG GFVVLDQTTG AAMNASPPSL YGGGGGPNAG
ISGGAGASGA AGSNGGHQPG GGGGARSHIP TAQLHHSAAA AAAAAAGSQQ ATAAVLSGVA
AAAALGGYNP NGASGVYFKY GQTYFAHPSV ALPNSRRSPS NDIRPQMAQV AGMYPTMMIQ
ARHPSRHPNP NYKGSRPR
