ID   END1_BUCAI              Reviewed;         250 AA.
AC   P57487;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Endonuclease-1;
DE            EC=3.1.21.1;
DE   AltName: Full=Endonuclease I;
DE            Short=Endo I;
GN   Name=endA; OrderedLocusNames=BU409;
OS   Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon
OS   pisum symbiotic bacterium).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=107806;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=APS;
RX   PubMed=10993077; DOI=10.1038/35024074;
RA   Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
RT   "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera
RT   sp. APS.";
RL   Nature 407:81-86(2000).
CC   -!- FUNCTION: Has double-strand break activity. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-
CC         phosphooligonucleotide end-products.; EC=3.1.21.1;
CC   -!- SIMILARITY: Belongs to the EndA/NucM nuclease family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000003; BAB13110.1; -; Genomic_DNA.
DR   RefSeq; NP_240224.1; NC_002528.1.
DR   RefSeq; WP_010896102.1; NC_002528.1.
DR   AlphaFoldDB; P57487; -.
DR   SMR; P57487; -.
DR   STRING; 107806.10039076; -.
DR   EnsemblBacteria; BAB13110; BAB13110; BAB13110.
DR   KEGG; buc:BU409; -.
DR   PATRIC; fig|107806.10.peg.421; -.
DR   eggNOG; COG2356; Bacteria.
DR   HOGENOM; CLU_070541_0_0_6; -.
DR   OMA; QSTEFYC; -.
DR   Proteomes; UP000001806; Chromosome.
DR   GO; GO:0004530; F:deoxyribonuclease I activity; IEA:UniProtKB-EC.
DR   InterPro; IPR007346; Endonuclease-I.
DR   InterPro; IPR044925; His-Me_finger_sf.
DR   PANTHER; PTHR33607; PTHR33607; 1.
DR   Pfam; PF04231; Endonuclease_1; 1.
DR   SUPFAM; SSF54060; SSF54060; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..250
FT                   /note="Endonuclease-1"
FT                   /id="PRO_0000207691"
SQ   SEQUENCE   250 AA;  30197 MW;  69C8E5775BC48CA6 CRC64;
     MKKFCFLKIE KIKNDKKNVY CYNKYVFFFS SNKRSYFKKK TIENFYQAKI ISIKIHKNAP
     GSFYCGCQII WKQKKGIPNL YSCGYKIRKN KNRATRIEWE HVVPAWQFGH QKTCWKKGGR
     KKCMEDKKYK HIESDLHNLQ PAIGEINGDR SNFMYGQLNN SVAQYGRCNM KIDFKRKIVE
     PPERARGAIA RTYFYMNKKY NIILSEKERK MFTIWDKIFP VTKWECEREK LIFNIQGNHN
     DYVYKHCYKK