AGC1_ASHGO
ID AGC1_ASHGO Reviewed; 911 AA.
AC Q75AH6;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 2.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Mitochondrial aspartate-glutamate transporter AGC1;
DE AltName: Full=Aspartate-glutamate carrier 1;
GN Name=AGC1; OrderedLocusNames=ADL049W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Calcium-dependent mitochondrial aspartate and glutamate
CC carrier. Transport of glutamate in mitochondria is required for
CC mitochondrial transamination reactions and ornithine synthesis. Plays
CC also a role in malate-aspartate NADH shuttle, which is critical for
CC growth on acetate and fatty acids (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAS51871.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE016817; AAS51871.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_984047.1; NM_209400.1.
DR AlphaFoldDB; Q75AH6; -.
DR SMR; Q75AH6; -.
DR STRING; 33169.AAS51871; -.
DR GeneID; 4620195; -.
DR KEGG; ago:AGOS_ADL049W; -.
DR eggNOG; KOG0751; Eukaryota.
DR InParanoid; Q75AH6; -.
DR OMA; YYYKSCQ; -.
DR Proteomes; UP000000591; Chromosome IV.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015183; F:L-aspartate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005313; F:L-glutamate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015810; P:aspartate transmembrane transport; IBA:GO_Central.
DR GO; GO:0015813; P:L-glutamate transmembrane transport; IBA:GO_Central.
DR GO; GO:0043490; P:malate-aspartate shuttle; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Amino-acid transport; Calcium; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..911
FT /note="Mitochondrial aspartate-glutamate transporter AGC1"
FT /id="PRO_0000227600"
FT TRANSMEM 524..544
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 584..604
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 621..641
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 663..683
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 723..743
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 778..798
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 521..607
FT /note="Solcar 1"
FT REPEAT 615..702
FT /note="Solcar 2"
FT REPEAT 717..805
FT /note="Solcar 3"
SQ SEQUENCE 911 AA; 104906 MW; FB488859EE0A2C4B CRC64;
MELSSASTVK KKRQLAIFNA YATPLRQDER RLRASYEHGG VVGGHVASNE KVLLFDDFVD
LISNSRSFYS KFTDHCFNLN QIPNTVFGCI FFAIDENNKG YLNVNDWFYF NNVLEYDNYH
FIILYEFFRK FDAARERAYG PSVKSINYGN RFLSFDELYL DLEQFQATLR LLHSCVRDDF
IVNNKLFLDW KQFRWLKWYQ FYPRGLLQNG PHITLNSLIS IVQNDLKSEK LLLGFHCLSQ
LDHRTNSMTI SKNQLVYLMR LFYSHKIPAD IFNSLNMSTL SCAKCDNNHI NYNVFRDLFY
LIQNFDLLNQ IVHRYAEVHK FSDRDVREQH ISRKDLLRFM NTEYNKINNI IEFSPAQISL
LFSIVTNSKK LNYLNNARQN NPELSYHHRD SEIDSFIHNE YINGNAASSL HNESLEKFND
DFENIIQADA GDTKQQISST DWRSVFSWSS FLSSFEWLHF KKRKSVQTNG LSDEYVNEAL
TLEDIMKIVN PNYLNDLVHH MELRRIESES RSSNLYFYPI FDSIYNFTLG SVAGCIGAMV
VYPIDMVKTR MQAQRDFSKY KNSIDCLLKI LSKEGVRGLY SGLGPQLIGV APEKAIKLTV
NDHMRATLAG RDGKLSLPCE IISGATAGAC QVVFTNPLEI VKIRLQVKSD YVADAARNSV
NAISVIKNLG LIGLYRGAGA CLLRDIPFSA IYFPTYAHIK SNVFNFDPKD SDKRNKLNTW
QLLVSGGLAG MPAAFLTTPF DVIKTRLQID PKKGESVYNG IWDAARTILK EEGIKSFFKG
GPARVLRSSP QFGFTLAAYE IFHNLFPAPR YDDSTTHRPT REPVGALAPI NKTVSAFFPD
QLEPHVGNNK WASRLYGPNI DPYSSSFLNY YYKSCQVAKA FMDLDYNFAH FDFNTYQQFH
DELNAMKNKK H
