ID   END4_YEREN              Reviewed;          35 AA.
AC   P42691;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Probable endonuclease 4;
DE            EC=3.1.21.2;
DE   AltName: Full=Endodeoxyribonuclease IV;
DE   AltName: Full=Endonuclease IV;
DE   Flags: Fragment;
GN   Name=nfo;
OS   Yersinia enterocolitica.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=630;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=W1024 / Serotype O:9;
RX   PubMed=8105362; DOI=10.1111/j.1365-2958.1993.tb01712.x;
RA   Iriarte M., Vanooteghem J.-C., Delor I., Diaz R., Knutton S.,
RA   Cornelis G.R.;
RT   "The Myf fibrillae of Yersinia enterocolitica.";
RL   Mol. Microbiol. 9:507-520(1993).
RN   [2]
RP   IDENTIFICATION.
RA   Robison K.;
RL   Unpublished observations (MAY-1995).
CC   -!- FUNCTION: Endonuclease IV plays a role in DNA repair. It cleaves
CC       phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating
CC       a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphooligonucleotide end-
CC         products.; EC=3.1.21.2;
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=Binds 3 Zn(2+) ions. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the AP endonuclease 2 family. {ECO:0000305}.
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DR   EMBL; Z21953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P42691; -.
DR   SMR; P42691; -.
DR   STRING; 1443113.LC20_03577; -.
DR   eggNOG; COG0648; Bacteria.
DR   GO; GO:0008833; F:deoxyribonuclease IV (phage-T4-induced) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   SUPFAM; SSF51658; SSF51658; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Endonuclease; Hydrolase; Metal-binding; Nuclease;
KW   Zinc.
FT   CHAIN           <1..35
FT                   /note="Probable endonuclease 4"
FT                   /id="PRO_0000190889"
FT   BINDING         15
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   35 AA;  4138 MW;  C79055DFE927539E CRC64;
     IMRDPRFDNI PLILETVNPD IWAEEIAWLK SQAEI