AGD9_ARATH
ID AGD9_ARATH Reviewed; 402 AA.
AC Q9FIQ0;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 123.
DE RecName: Full=Probable ADP-ribosylation factor GTPase-activating protein AGD9;
DE Short=ARF GAP AGD9;
DE AltName: Full=Protein ARF-GAP DOMAIN 9;
DE Short=AtAGD9;
GN Name=AGD9; OrderedLocusNames=At5g46750; ORFNames=MZA15.17;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10048488; DOI=10.1093/dnares/5.6.379;
RA Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence
RT features of the regions of 1,081,958 bp covered by seventeen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:379-391(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12644670; DOI=10.1104/pp.013052;
RA Vernoud V., Horton A.C., Yang Z., Nielsen E.;
RT "Analysis of the small GTPase gene superfamily of Arabidopsis.";
RL Plant Physiol. 131:1191-1208(2003).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22223895; DOI=10.1074/mcp.m111.015131;
RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA Giglione C.;
RT "Comparative large-scale characterisation of plant vs. mammal proteins
RT reveals similar and idiosyncratic N-alpha acetylation features.";
RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
CC -!- FUNCTION: GTPase-activating protein (GAP) for ADP ribosylation factor
CC (ARF). {ECO:0000250}.
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DR EMBL; AB016882; BAB08919.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95421.1; -; Genomic_DNA.
DR EMBL; AY099693; AAM20544.1; -; mRNA.
DR EMBL; AY128872; AAM91272.1; -; mRNA.
DR RefSeq; NP_199487.1; NM_124045.5.
DR AlphaFoldDB; Q9FIQ0; -.
DR SMR; Q9FIQ0; -.
DR BioGRID; 19966; 2.
DR IntAct; Q9FIQ0; 1.
DR STRING; 3702.AT5G46750.1; -.
DR iPTMnet; Q9FIQ0; -.
DR PaxDb; Q9FIQ0; -.
DR PRIDE; Q9FIQ0; -.
DR ProteomicsDB; 244743; -.
DR EnsemblPlants; AT5G46750.1; AT5G46750.1; AT5G46750.
DR GeneID; 834718; -.
DR Gramene; AT5G46750.1; AT5G46750.1; AT5G46750.
DR KEGG; ath:AT5G46750; -.
DR Araport; AT5G46750; -.
DR TAIR; locus:2178545; AT5G46750.
DR eggNOG; KOG0706; Eukaryota.
DR HOGENOM; CLU_023062_0_0_1; -.
DR InParanoid; Q9FIQ0; -.
DR OMA; QNVGESI; -.
DR OrthoDB; 1155557at2759; -.
DR PhylomeDB; Q9FIQ0; -.
DR PRO; PR:Q9FIQ0; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FIQ0; baseline and differential.
DR Genevisible; Q9FIQ0; AT.
DR GO; GO:0000139; C:Golgi membrane; IEA:GOC.
DR GO; GO:0009536; C:plastid; HDA:TAIR.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048205; P:COPI coating of Golgi vesicle; IBA:GO_Central.
DR Gene3D; 1.10.220.150; -; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR Pfam; PF01412; ArfGap; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SUPFAM; SSF57863; SSF57863; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 1: Evidence at protein level;
KW Acetylation; GTPase activation; Metal-binding; Phosphoprotein;
KW Reference proteome; Zinc; Zinc-finger.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22223895"
FT CHAIN 2..402
FT /note="Probable ADP-ribosylation factor GTPase-activating
FT protein AGD9"
FT /id="PRO_0000352500"
FT DOMAIN 10..128
FT /note="Arf-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT ZN_FING 25..48
FT /note="C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT REGION 133..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:22223895"
FT MOD_RES 307
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19376835"
SQ SEQUENCE 402 AA; 43550 MW; 553B39E89E4BDB92 CRC64;
MATENLTDKN VVFRKLKSKS ENKVCFDCSA KNPTWASVPY GIFLCIDCSA VHRSLGVHIS
FVRSTNLDSW SPEQLRTMMF GGNNRAQVFF KQHGWNDGGK IEAKYTSRAA DMYRQTLAKE
VAKAMAEETV LPSLSSVATS QPVESSENGF TSESPKESSL KQEAAVVSSP KASQKVVAST
FKKPLVSRKS GKTGGLGARK LTTKSKDNLY EQKPEEPVPV IPAASPTNDT SAAGSSFASR
FEYFDDEQSG GQSGTRVLSH VAPPKSSNFF NEFGMDSAFP KKSSSSSSKA QVEETDEARK
KFSNAKSISS AQFFGNQNRD ADLDSKATLQ KFSGSAAISS SDLFGHGPDD SNIDITASDL
INRISFQAQQ DMSSIANLAE ETKNKLGTFA SSIFSDLQDR ML
