ID   ENDAL_METKA             Reviewed;         166 AA.
AC   Q8TGZ5;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=EndA-like protein;
GN   OrderedLocusNames=MK0397;
OS   Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938).
OC   Archaea; Euryarchaeota; Methanopyri; Methanopyrales; Methanopyraceae;
OC   Methanopyrus.
OX   NCBI_TaxID=190192;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AV19 / DSM 6324 / JCM 9639 / NBRC 100938;
RX   PubMed=11930014; DOI=10.1073/pnas.032671499;
RA   Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N.,
RA   Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A.,
RA   Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G.,
RA   Koonin E.V., Kozyavkin S.A.;
RT   "The complete genome of hyperthermophile Methanopyrus kandleri AV19 and
RT   monophyly of archaeal methanogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002).
CC   -!- SIMILARITY: Belongs to the tRNA-intron endonuclease family. Archaeal
CC       short subfamily. {ECO:0000305}.
CC   -!- CAUTION: Although strongly related to the EndA enzyme, it does not
CC       contain the conserved Tyr-His-Lys active sites, preventing tRNA-
CC       splicing activity. {ECO:0000305}.
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DR   EMBL; AE009439; AAM01612.1; -; Genomic_DNA.
DR   PDB; 5X89; X-ray; 1.53 A; A=2-166.
DR   PDBsum; 5X89; -.
DR   AlphaFoldDB; Q8TGZ5; -.
DR   SMR; Q8TGZ5; -.
DR   STRING; 190192.MK0397; -.
DR   EnsemblBacteria; AAM01612; AAM01612; MK0397.
DR   KEGG; mka:MK0397; -.
DR   HOGENOM; CLU_114393_0_0_2; -.
DR   OMA; ENINAIH; -.
DR   BRENDA; 4.6.1.16; 3274.
DR   Proteomes; UP000001826; Chromosome.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000213; F:tRNA-intron endonuclease activity; IEA:InterPro.
DR   GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IEA:InterPro.
DR   Gene3D; 3.40.1350.10; -; 1.
DR   InterPro; IPR011856; tRNA_endonuc-like_dom_sf.
DR   InterPro; IPR036167; tRNA_intron_Endo_cat-like_sf.
DR   InterPro; IPR006677; tRNA_intron_Endonuc_cat-like.
DR   InterPro; IPR006678; tRNA_intron_Endonuc_N.
DR   InterPro; IPR036740; tRNA_intron_Endonuc_N_sf.
DR   InterPro; IPR006676; tRNA_splic.
DR   InterPro; IPR016442; tRNA_splic_arch_short.
DR   PANTHER; PTHR21227; PTHR21227; 1.
DR   Pfam; PF01974; tRNA_int_endo; 1.
DR   Pfam; PF02778; tRNA_int_endo_N; 1.
DR   PIRSF; PIRSF005285; tRNA_splic_archaea; 1.
DR   SUPFAM; SSF53032; SSF53032; 1.
DR   SUPFAM; SSF55267; SSF55267; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome.
FT   CHAIN           1..166
FT                   /note="EndA-like protein"
FT                   /id="PRO_0000109483"
FT   STRAND          3..8
FT                   /evidence="ECO:0007829|PDB:5X89"
FT   STRAND          11..14
FT                   /evidence="ECO:0007829|PDB:5X89"
FT   HELIX           17..24
FT                   /evidence="ECO:0007829|PDB:5X89"
FT   TURN            25..27
FT                   /evidence="ECO:0007829|PDB:5X89"
FT   STRAND          35..38
FT                   /evidence="ECO:0007829|PDB:5X89"
FT   HELIX           40..48
FT                   /evidence="ECO:0007829|PDB:5X89"
FT   STRAND          51..56
FT                   /evidence="ECO:0007829|PDB:5X89"
FT   STRAND          59..61
FT                   /evidence="ECO:0007829|PDB:5X89"
FT   HELIX           63..73
FT                   /evidence="ECO:0007829|PDB:5X89"
FT   HELIX           77..89
FT                   /evidence="ECO:0007829|PDB:5X89"
FT   STRAND          93..98
FT                   /evidence="ECO:0007829|PDB:5X89"
FT   HELIX           99..101
FT                   /evidence="ECO:0007829|PDB:5X89"
FT   STRAND          102..108
FT                   /evidence="ECO:0007829|PDB:5X89"
FT   TURN            109..111
FT                   /evidence="ECO:0007829|PDB:5X89"
FT   STRAND          112..120
FT                   /evidence="ECO:0007829|PDB:5X89"
FT   TURN            121..123
FT                   /evidence="ECO:0007829|PDB:5X89"
FT   HELIX           128..138
FT                   /evidence="ECO:0007829|PDB:5X89"
FT   STRAND          144..150
FT                   /evidence="ECO:0007829|PDB:5X89"
FT   STRAND          156..164
FT                   /evidence="ECO:0007829|PDB:5X89"
SQ   SEQUENCE   166 AA;  19413 MW;  80A7D613FFEBE3AF CRC64;
     MAAKGELVGS KVLVRNDRDA NRLYSSMYGK PSRRGLQLWP EEALFLCEIG RLEVRSGNVR
     ISPEELMDRF VEEDPRFPVR YAVYADLRRR GWKPKPGRKF GTEFRAFRGE DERIAVKVLQ
     EELDEFTAQD ILEWLKLVEG TEFELVVAIV DNDYDLNYYV FSELVL