ENDD1_MOUSE
ID ENDD1_MOUSE Reviewed; 501 AA.
AC Q8C522; Q4VA96; Q8C5M1; Q8VE35;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Endonuclease domain-containing 1 protein;
DE EC=3.1.30.-;
DE Flags: Precursor;
GN Name=Endod1; Synonyms=Kiaa0830;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II, and FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 195-208 AND 239-252, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Lubec G., Kang S.U.;
RL Submitted (APR-2007) to UniProtKB.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May act as a DNase and a RNase. Plays a role in the
CC modulation of innate immune signaling through the cGAS-STING pathway by
CC interacting with RNF26. {ECO:0000250|UniProtKB:O94919}.
CC -!- SUBUNIT: Interacts with RNF26; this interaction is important to
CC modulate innate immune signaling through the cGAS-STING pathway.
CC {ECO:0000250|UniProtKB:O94919}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the DNA/RNA non-specific endonuclease family.
CC {ECO:0000305}.
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DR EMBL; AK078056; BAC37111.1; -; mRNA.
DR EMBL; AK079741; BAC37737.1; -; mRNA.
DR EMBL; BC019813; AAH19813.1; -; mRNA.
DR EMBL; BC096490; AAH96490.1; -; mRNA.
DR CCDS; CCDS22821.1; -.
DR RefSeq; NP_082289.2; NM_028013.3.
DR AlphaFoldDB; Q8C522; -.
DR SMR; Q8C522; -.
DR BioGRID; 215047; 11.
DR STRING; 10090.ENSMUSP00000127751; -.
DR iPTMnet; Q8C522; -.
DR PhosphoSitePlus; Q8C522; -.
DR SwissPalm; Q8C522; -.
DR EPD; Q8C522; -.
DR MaxQB; Q8C522; -.
DR PaxDb; Q8C522; -.
DR PeptideAtlas; Q8C522; -.
DR PRIDE; Q8C522; -.
DR ProteomicsDB; 275661; -.
DR Antibodypedia; 2196; 99 antibodies from 21 providers.
DR DNASU; 71946; -.
DR Ensembl; ENSMUST00000167549; ENSMUSP00000127751; ENSMUSG00000037419.
DR GeneID; 71946; -.
DR KEGG; mmu:71946; -.
DR UCSC; uc009oel.2; mouse.
DR CTD; 23052; -.
DR MGI; MGI:1919196; Endod1.
DR VEuPathDB; HostDB:ENSMUSG00000037419; -.
DR eggNOG; ENOG502QQYK; Eukaryota.
DR GeneTree; ENSGT01030000234592; -.
DR HOGENOM; CLU_035817_0_0_1; -.
DR InParanoid; Q8C522; -.
DR OMA; FQERWYM; -.
DR OrthoDB; 858590at2759; -.
DR PhylomeDB; Q8C522; -.
DR TreeFam; TF333322; -.
DR Reactome; R-MMU-114608; Platelet degranulation.
DR BioGRID-ORCS; 71946; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Endod1; mouse.
DR PRO; PR:Q8C522; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8C522; protein.
DR Bgee; ENSMUSG00000037419; Expressed in lateral hypothalamic area and 233 other tissues.
DR ExpressionAtlas; Q8C522; baseline and differential.
DR Genevisible; Q8C522; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR Gene3D; 3.40.570.10; -; 1.
DR InterPro; IPR044929; DNA/RNA_non-sp_Endonuclease_sf.
DR InterPro; IPR039015; ENDOD1.
DR InterPro; IPR020821; Extracellular_endonuc_su_A.
DR InterPro; IPR044925; His-Me_finger_sf.
DR PANTHER; PTHR21472; PTHR21472; 1.
DR SMART; SM00477; NUC; 1.
DR SUPFAM; SSF54060; SSF54060; 1.
PE 1: Evidence at protein level;
KW Acetylation; Direct protein sequencing; Endonuclease; Hydrolase; Immunity;
KW Innate immunity; Nuclease; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..501
FT /note="Endonuclease domain-containing 1 protein"
FT /id="PRO_0000019925"
FT MOD_RES 408
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O94919"
FT CONFLICT 118
FT /note="L -> V (in Ref. 2; AAH19813)"
FT /evidence="ECO:0000305"
FT CONFLICT 148
FT /note="P -> H (in Ref. 2; AAH19813)"
FT /evidence="ECO:0000305"
FT CONFLICT 396
FT /note="V -> L (in Ref. 1; BAC37111)"
FT /evidence="ECO:0000305"
FT CONFLICT 440
FT /note="T -> S (in Ref. 2; AAH19813)"
FT /evidence="ECO:0000305"
FT CONFLICT 463
FT /note="T -> N (in Ref. 1; BAC37111)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 501 AA; 55262 MW; 18E08148DD8D42B7 CRC64;
MGCARWLALG GLLALAGLLQ ARLLLPQQAG FGECDRFFYK GTPPAGLATE AHVRICQRFA
GSERFATLYS PGHRIPVFSA FRAARPASRS AEQRGLLEPQ IDDPDSNLEE VIDEANALTS
VDNLGSKQAL NADYIDSDYE IGQLYPFPLN SDLQMATFPL TNSVPMTQSF RERWHMNLNS
LMDRALIPHC SEGKDLYILT GAVPSEHRVK GKVTIPEFVW LAACCAVPGE GWAMGFIKHT
QDIDVIEDVM LRDLEKLLPH KPQLFQDNCG EMEQDTEKMK KILEVVNQVQ DEERSLQSQE
RMSPLASTQS QRSALLSPEA PPEGGSSFLG QVLGFLATPF IKLFQLIYYL VTAVLRNIVH
LLWLVAKQAI NTVESCLYHL GEATVSYLVA IGQELVSIPW KVLKVVAKVI RAFLRILCCL
LKAVCRALSI PLRVLVDVAT FPVYTVGAIP IVCKDIAVGL GGTLSLLFDT AFGTVGGLFQ
IVFSVFKRIG YKVTLDNSGE F
