ID   ENDP1_SALTI             Reviewed;         804 AA.
AC   Q8Z365; Q7C6T0;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Probable replication endonuclease from prophage-like region 1;
DE            EC=3.1.-.-;
GN   OrderedLocusNames=STY3668, t3410;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Possible endonuclease which induces a single-strand cut and
CC       initiates DNA replication. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the phage GPA family. {ECO:0000305}.
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DR   EMBL; AL513382; CAD09429.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO70933.1; -; Genomic_DNA.
DR   RefSeq; NP_457859.1; NC_003198.1.
DR   RefSeq; WP_000017503.1; NZ_WSUR01000054.1.
DR   AlphaFoldDB; Q8Z365; -.
DR   STRING; 220341.16504546; -.
DR   EnsemblBacteria; AAO70933; AAO70933; t3410.
DR   KEGG; stt:t3410; -.
DR   KEGG; sty:STY3668; -.
DR   PATRIC; fig|220341.7.peg.3737; -.
DR   eggNOG; ENOG502Z7TX; Bacteria.
DR   HOGENOM; CLU_013772_2_0_6; -.
DR   OMA; ACGDLYA; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR008766; Replication_gene_A.
DR   Pfam; PF05840; Phage_GPA; 1.
PE   3: Inferred from homology;
KW   DNA replication; Endonuclease; Hydrolase; Nuclease.
FT   CHAIN           1..804
FT                   /note="Probable replication endonuclease from prophage-like
FT                   region 1"
FT                   /id="PRO_0000278166"
FT   ACT_SITE        498
FT                   /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        502
FT                   /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   804 AA;  92495 MW;  9C9F03D92C6D2E0C CRC64;
     MSHADMNNCS GFNEAAAAFS WNSPKKAINP YLDLAEVAPV SALSNLITLY AADNEQEQLR
     REALSDQVWE RYFFNESRDP VQREMEQDKF ISRAKLAHEQ QRFNPDMVIL ADVNAQPSHI
     SRPLMQRIEY FSSLGRPKAY SRYLRETIKP CLERLEHVRD SQLSTSFRFM ASHEGLDGLL
     ILPEMSQDQV KRLSTLVAAH MSMCLDAACG DLYATDDVKP EEIRKTWEKV AAETLRLDVI
     PPAFEQLRRK RNRRKPVPYE LIPGSLARML CADWWYRKLW KMRCEWREEQ LRAVCLVSKK
     ASPYVSYEAM MHKREQRRKS LEFFRSHELV NEDGDTLDME DVVNASSSNP AHRRNEMMAC
     VKGLELIAEM RGDCAVFYTI TCPSRFHSTL NNGRPNPTWT NTTVRQSSDY LVGMFAAFRK
     AMHKAGLRWY GVRVAEPHHD GTVHWHLLCF MRKKDRRTIT ALLRKFAIRE DREELGNNTG
     PRFKSELINP RKGTPTSYIA KYISKNIDGR GLAGEISKET GKSLRDNAEY VNAWASLHRV
     QQFRFFGIPG RQAYRELRLL AGQAARQQGD KKAGAPVLDN PRLDAILAAA DAGCFATYIM
     KQGGVLVPRK YHLIRTAYEI NEEPTAYGDH GIRIYGIWSP IAEGKICTHA VKWKMVRKAV
     DVQEAAADQG ACAPWTRGNN CPLAENLNQH EKDKSADGDT RTDITCMDDK ELHDYLHSMG
     KKEHRELAAR LRLVKPKRRK DHKQRITEHQ RQQLVYELKS RGFDGSEKEV DLLLRGGSIP
     SGAGLRIFYR NQRLQEDDKW RDLY