ID   ENDP2_SALTI             Reviewed;         804 AA.
AC   Q8Z1E1; Q83SS6;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Probable replication endonuclease from prophage-like region 2;
DE            EC=3.1.-.-;
GN   OrderedLocusNames=STY4635, t4328;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Possible endonuclease which induces a single-strand cut and
CC       initiates DNA replication. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the phage GPA family. {ECO:0000305}.
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DR   EMBL; AL513382; CAD06756.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO71782.1; -; Genomic_DNA.
DR   RefSeq; NP_458715.1; NC_003198.1.
DR   RefSeq; WP_000301194.1; NZ_PZMG01000016.1.
DR   AlphaFoldDB; Q8Z1E1; -.
DR   STRING; 220341.16505406; -.
DR   EnsemblBacteria; AAO71782; AAO71782; t4328.
DR   KEGG; stt:t4328; -.
DR   KEGG; sty:STY4635; -.
DR   PATRIC; fig|220341.7.peg.4734; -.
DR   eggNOG; ENOG502Z7TX; Bacteria.
DR   HOGENOM; CLU_013772_2_0_6; -.
DR   OMA; ENERCQE; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR008766; Replication_gene_A.
DR   Pfam; PF05840; Phage_GPA; 1.
PE   3: Inferred from homology;
KW   DNA replication; Endonuclease; Hydrolase; Nuclease.
FT   CHAIN           1..804
FT                   /note="Probable replication endonuclease from prophage-like
FT                   region 2"
FT                   /id="PRO_0000278167"
FT   ACT_SITE        503
FT                   /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        507
FT                   /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        685..686
FT                   /note="Missing (in Ref. 2; AAO71782)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   804 AA;  92043 MW;  77253E91CDBFCC43 CRC64;
     MAVSKITLHY AQTTGGSNEA AAAFPWNTPK KAVNPYLDPA EFAPESALSN LIALYAVDNE
     QEQLRRETLS DEVWERYFFN ESRDPVQREM EQDRLINHAK TAREQQRFNP DLVIIANVGA
     QPAHISKPLL ERIKYFHSLG RAKAYSRYLQ KTIRPCLERL ERVRDSQVSA SFRFMASHDG
     LEGLLVLPEM NQDQVKRLST LVAAHMSMCL DAACGDLFVS DDVKPEEIRQ AWERVAAEAM
     RLEVIPPAFE QLRRKKRRRK PVPYELIPPS LARMLCADWW YRKLWQMRCE WREEQLRAVC
     LVNKKASPYV SYEAVIHKRE QRRKSLEFFR SHELINEDGD TLDMEDVVNA SNSNPAHRRN
     EMMACVKGLE LIAEMRGDCA VFYTITCPSR FHATLNNGRP NPKWTSATVR QSSDYLVDTF
     AAFRKAMHKA GLRWYGVRVA EPHHDGTVHW HLLCFMRKKD RRSITALLRK FAIREDREEL
     GANTGPRFKP ELINPRKGTP TSYIAKYISK NIDGRGLAKE ISKETGRSLR DSAEHVSAWA
     SLHRVQQFRF FGIPGRQAYR ELRLLAGQAA RVQGERKAGA PVLDNPRLDA VLAAADAGCF
     ATYIMKQGGV LVPRKHHLVR TAYELNDEPS AYGDHGIRIY GIWSPIAEGK ICTHAVKWKK
     VRKAVDVQEA AADQGACAPW TRTRTRGNNC PPVENLNKSG GDLPDIKTMN EKELQDYLHN
     MGQKERRELT ARLRLVKPKR KTVYKQNISE QQRLQLEAEL TARGFEGSAS EIDLLLRGGS
     IPSGAGLRIF YRNHRLQEDD KWRQ