ID   ENDPH_ECOL6             Reviewed;         804 AA.
AC   Q8FJJ0;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Probable replication endonuclease from prophage-like region;
DE            EC=3.1.-.-;
GN   OrderedLocusNames=c0942;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Possible endonuclease which induces a single-strand cut and
CC       initiates DNA replication. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the phage GPA family. {ECO:0000305}.
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DR   EMBL; AE014075; AAN79415.1; -; Genomic_DNA.
DR   RefSeq; WP_000017614.1; NC_004431.1.
DR   AlphaFoldDB; Q8FJJ0; -.
DR   STRING; 199310.c0942; -.
DR   EnsemblBacteria; AAN79415; AAN79415; c0942.
DR   KEGG; ecc:c0942; -.
DR   eggNOG; ENOG502Z7TX; Bacteria.
DR   HOGENOM; CLU_013772_2_0_6; -.
DR   OMA; ACGDLYA; -.
DR   BioCyc; ECOL199310:C0942-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR008766; Replication_gene_A.
DR   Pfam; PF05840; Phage_GPA; 1.
PE   3: Inferred from homology;
KW   DNA replication; Endonuclease; Hydrolase; Nuclease.
FT   CHAIN           1..804
FT                   /note="Probable replication endonuclease from prophage-like
FT                   region"
FT                   /id="PRO_0000278164"
FT   ACT_SITE        498
FT                   /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        502
FT                   /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   804 AA;  92433 MW;  C0B0C40542EC546C CRC64;
     MSHDDMSNSS GFNEAAASFS WNGPKKAINP YLDPAEVAPE SALSNLITLY AADNEQEQLR
     REALSEQVWE RYFFNESRDP VQREMEQDKL ISRAKLAHEQ QRFNPDMVIL ADVNAQPSHI
     SKPLMQRIEY FSSLGRPKAY SRYLRETIKP CLERLEHIRD SQLSTSFRFM ASHEGLDGLL
     ILPEMSQEQV KRLSTLVAAH MSMCLDAACG DLYATDDVKP EEIRKTWERV AAETLRLDVI
     PPAFEQLRRK RNRRKPVPYE LIPGSLARML CADWWYRKLW KMRCEWREEQ LRAVCLVSKK
     ASPYVSYEAV MHKREQRRKS LEFFRSHELV NEDGDTLDME DVVNASSSNP AHRRNEMMAC
     VKGLELIAEM RGDCAVFYTI TCPSRFHSTL NNGRPNPTWT NATVRQSSDY LVGMFAAFRK
     AMHKAGLRWY GVRVAEPHHD GTVHWHLLCF MRKKDRRAIT ALLCKFAIRE DREELGNNTG
     PRFKSELINP RKGTPTSYIA KYISKNIDGR GLAGEISKET GKSLRDNAEY VNAWASLHRV
     QQFRFFGIPG RQAYRELRLL AGQAARQQGD KKAGAPVLDN PRLDAILAAA DAGCFATYIM
     KQGGVLVPRK YHLIRTAYEI NEEPTAYGDH GIRIYGIWSP IAEGKICTHA VKWKMVRKAV
     DVQEAVADQG ACAPWTRGNN CPLAENLNQQ AKDKSADGDT RTDITRMDDK ELHDYLHSMS
     KKERRELAAR LRLVKPKRRK DYKQRITDHQ RQQLVYELKS RGFDGSEKEV DLLLRGGSIP
     SGAGLRIFYR NQRLQEDDKW RNLY