ID   ENDPH_SALTY             Reviewed;         809 AA.
AC   Q8ZMS4;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Probable replication endonuclease from prophage-like region;
DE            EC=3.1.-.-;
DE   AltName: Full=Fels-2 prophage protein;
GN   OrderedLocusNames=STM2729;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Possible endonuclease which induces a single-strand cut and
CC       initiates DNA replication. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the phage GPA family. {ECO:0000305}.
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DR   EMBL; AE006468; AAL21615.1; -; Genomic_DNA.
DR   RefSeq; WP_000301161.1; NC_003197.2.
DR   AlphaFoldDB; Q8ZMS4; -.
DR   STRING; 99287.STM2729; -.
DR   PaxDb; Q8ZMS4; -.
DR   EnsemblBacteria; AAL21615; AAL21615; STM2729.
DR   PATRIC; fig|99287.12.peg.2878; -.
DR   HOGENOM; CLU_013772_2_0_6; -.
DR   BioCyc; SENT99287:STM2729-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR008766; Replication_gene_A.
DR   Pfam; PF05840; Phage_GPA; 1.
PE   3: Inferred from homology;
KW   DNA replication; Endonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..809
FT                   /note="Probable replication endonuclease from prophage-like
FT                   region"
FT                   /id="PRO_0000278168"
FT   ACT_SITE        503
FT                   /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        507
FT                   /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   809 AA;  92887 MW;  D15B50101F62ABEE CRC64;
     MAVSKFTLHN APTTGGSNEA AVVFPWNTPK KAVNPYLDPA EVAPESALSN LIALYAADNE
     QEQLRRETLS DEVWERYFFN ESRDPVQREI EQDRLISHAK TAREQQRFNP DLVIIADVGA
     QPAHISKPLL ERIKYFHSLG RAKAYSRYLR ETIRPCLERL ERVRDSQVSA SFRFMASHDG
     LEGLLVLPEM NQDQVKRLST LVAAHMSMCL DAACGDLFVS DDVKPEEIRQ AWERVAAEAM
     RLEVIPPAFE QLRRKKRRRK PVPYELIPPS LARMLCADWW CRKLWQMRCE WREEQLRAVC
     LVNKKASPYV SYEAVIHKRE QRRKSLEFFR SHELINEDGD TLDMEDVVNA SNSNPAHRRN
     EMMACVKGLE LIAEMRGDCA VFYTITCPSR FHATLNNGRP NPKWTSATVR QSSDYLVDTF
     AAFRKAMHKT GLRWYGVRVA EPHHDGTVHW HLLCFMRKKD RRSITALLRK FAIREDREEL
     GTNTGPRFKS ELINPRKGTP TSYIAKYISK NIDGRGLAKE ISKETGRPLR DSAEHVSAWA
     SLHRVQQFRF FGIPGRQAYR ELRLLAGQAA RVQGERKAGA PVLDNPRLDA VLAAADAGCF
     ATYIMKQGGV LVPRKHHLVR TAYELNDEPS AYGDHGIRIY GIWSPIAEGK ICTHAMKWKK
     VRKAVDVQEA AADQGACAPW TRGNNCPLAE NLNQQEKDKS ADGGTRTDIT RMDDKELHDY
     LYSMSKKDRR ELAARLRLVK PKRRKDYKQR ITDHQHQQLV YELKSRGFDG SEKEVDLLLR
     GGSIPSGAGL RIFYRNQRLK EDDKWRNQY