ID   ENDPH_SHIBS             Reviewed;         804 AA.
AC   Q323T3;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Probable replication endonuclease from prophage-like region;
DE            EC=3.1.-.-;
GN   OrderedLocusNames=SBO_0752;
OS   Shigella boydii serotype 4 (strain Sb227).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=300268;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sb227;
RX   PubMed=16275786; DOI=10.1093/nar/gki954;
RA   Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J.,
RA   Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J.,
RA   Xu J., Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J.,
RA   Jin Q.;
RT   "Genome dynamics and diversity of Shigella species, the etiologic agents of
RT   bacillary dysentery.";
RL   Nucleic Acids Res. 33:6445-6458(2005).
CC   -!- FUNCTION: Possible endonuclease which induces a single-strand cut and
CC       initiates DNA replication. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the phage GPA family. {ECO:0000305}.
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DR   EMBL; CP000036; ABB65425.1; -; Genomic_DNA.
DR   RefSeq; WP_000017483.1; NC_007613.1.
DR   AlphaFoldDB; Q323T3; -.
DR   EnsemblBacteria; ABB65425; ABB65425; SBO_0752.
DR   KEGG; sbo:SBO_0752; -.
DR   HOGENOM; CLU_013772_2_0_6; -.
DR   OMA; ACGDLYA; -.
DR   Proteomes; UP000007067; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR008766; Replication_gene_A.
DR   Pfam; PF05840; Phage_GPA; 1.
PE   3: Inferred from homology;
KW   DNA replication; Endonuclease; Hydrolase; Nuclease.
FT   CHAIN           1..804
FT                   /note="Probable replication endonuclease from prophage-like
FT                   region"
FT                   /id="PRO_0000278169"
FT   ACT_SITE        498
FT                   /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        502
FT                   /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   804 AA;  92410 MW;  2F71749BB50483FF CRC64;
     MSHADMNNCC GFNEAAAAFS WNSPKKAINP YLDPAEVAPV SALSNLITLY AADNEQEQLR
     REALSDQVWE RYFFYESRDP VQHEMEQDKL ISRAKLAHEQ QRFNPDMVIL ADVNAQPSHI
     SKPLMQRIEY FSSLGRPKAY SRYLRETIKP CLERLEHVRD SQLSASFRFM ASHVGLDGLL
     ILPEMSQDQV KRLSTLVAAH MSMCLDAACG DLYATDDVKP EEIRKTWEKV AAETLRLDVI
     PPAFEQLRRK RNRRKPVPYE LIPGSLARML CADWWYRKLW KMRCEWREEQ LRAVCLVSKK
     ASPYVSYEAV MHKREQRRKS LEFFRSHELV NEEGDTLDME DVVNASSSNP AHRRNEMMAC
     VKGLELIAEM RGDCAVFYTI TCPSRFHSTL NNGRPNPTWT NATVRQSSDY LVGMFAAFRK
     AMHKAGLRWY GVRVAEPHHD GTVHWHLLCF MRKKDRRAIT ALLRKFAIRE DREELGNNTG
     PRFKSELINP RKGTPTSYIA KYISKNIDGR GLAGEISKET GKSLRDNAEY VNPWASLHRV
     QQFRFFGIPG RQAYRELRLL AGQAARQQGD KKAGAPVLDN PRLDAILAAA DAGCFATYIM
     RQGGVLVPRK YHLIRTAYEI NEEPTAYGDH GIRIYGIWSP IAEGKICTHA VKWKMVRKAV
     DVQEAAADQG ACAPWTRGNN CLLAENLNQQ EKDKSADGNP RTDITSMDDK ELHDYLHSMS
     KKERRELAAR LRLVKPKRRK DYKQRITDHQ RLQLVYELKS RGFDGSEKEV DLLLRGGSIP
     SGAGLRIFYR NQRLQEDDQW RNLY