ID   AGGC_ECOLX              Reviewed;         842 AA.
AC   P46005;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Outer membrane usher protein AggC;
DE   Flags: Precursor;
GN   Name=aggC;
OS   Escherichia coli.
OG   Plasmid P17-2.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=O3:H2 / 17-2 / EAggEC;
RX   PubMed=7914189; DOI=10.1128/jb.176.16.4949-4957.1994;
RA   Savarino S.J., Fox P., Deng Y., Nataro J.P.;
RT   "Identification and characterization of a gene cluster mediating
RT   enteroaggregative Escherichia coli aggregative adherence fimbria I
RT   biogenesis.";
RL   J. Bacteriol. 176:4949-4957(1994).
CC   -!- FUNCTION: Involved in the export and assembly of the AAF/I fimbriae
CC       subunits across the outer membrane.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the fimbrial export usher family. {ECO:0000305}.
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DR   EMBL; U12894; AAA57452.1; -; Genomic_DNA.
DR   PIR; B55853; B55853.
DR   AlphaFoldDB; P46005; -.
DR   SMR; P46005; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015473; F:fimbrial usher porin activity; IEA:InterPro.
DR   GO; GO:0009297; P:pilus assembly; IEA:InterPro.
DR   Gene3D; 2.60.40.2070; -; 1.
DR   Gene3D; 2.60.40.2610; -; 1.
DR   Gene3D; 3.10.20.410; -; 1.
DR   InterPro; IPR000015; Fimb_usher.
DR   InterPro; IPR018030; Fimbrial_membr_usher_CS.
DR   InterPro; IPR042186; FimD_plug_dom.
DR   InterPro; IPR025949; PapC-like_C.
DR   InterPro; IPR043142; PapC-like_C_sf.
DR   InterPro; IPR025885; PapC_N.
DR   InterPro; IPR037224; PapC_N_sf.
DR   PANTHER; PTHR30451; PTHR30451; 1.
DR   Pfam; PF13953; PapC_C; 1.
DR   Pfam; PF13954; PapC_N; 1.
DR   Pfam; PF00577; Usher; 1.
DR   SUPFAM; SSF141729; SSF141729; 1.
DR   PROSITE; PS01151; FIMBRIAL_USHER; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Disulfide bond; Fimbrium biogenesis; Membrane;
KW   Plasmid; Signal; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..842
FT                   /note="Outer membrane usher protein AggC"
FT                   /id="PRO_0000009299"
FT   DISULFID        819..841
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   842 AA;  93321 MW;  B20E374F9DC8D63D CRC64;
     MKTSSFIIVI LLCFRIENVI AHTFSFDASL LNHGSGGIDL TLLEKGGQLP GIYPVDIILN
     GSRIDSRDIF FYTKKNRHGE YYLKPCLTRD ILINYGVKTE EYPNLFRQNS EKNRDSSDCA
     DLSVIPQATE DYHFIKQQLI LGIPQVAIRP PLTGIAHETM WDDGISAFLL NWQVEGSHWE
     YRSNTRNSSD NFWASLEPGI NLGSWRIRNL TTWNKSSGQS GKWESSYIRV ERGLNNIKSR
     LTFGDDYTPS DIFDSVPFRG GMLGSDENMV PYNQREFAPV VRGIARTQAR IEVRQNGYLI
     QSRIVSPGAF ALTDLPVTGN GGDLQVWVLE SDGTIQTFNV PFTTPAIALR EGYLKYNVTV
     GEYRPSDDSI EGAYLGQLTA MYGLPWSLTA FGGIQVSEHY QGNALGLGLS LGGFGSISLD
     TIYSRGQQKG YSNEIGKTWR VRYDKSFELT GTSFAAGYQD SSAGYHSLAD VLDTYRNGTA
     YRSYDNRIRR TTINISQALG EWGSVALNGG RDEYRDKVKQ DYIGASYSNS WKGITFAVNW
     SRNNNIGDYY SNSLRTENNL NLWMSIPMKR WLGGDDKGVT ATAQIQRITG QNTLYETGLN
     GRAFGQKLYW DIREQIVPGS KYDADTSLLN LRWSGGYGEL TGMYSYNRNT RQMNVGTSGS
     MAIHSGGIAF GQKTDDTMAL IAAPGIAGAS VGGWPGVSTD FRGYTLVGHV SPYQENIITL
     DPTTFPDNTE VSQTDRRVIP TKGALVQAEF KTRVGNRALV TLTRKDGTLL PFGTVVTLER
     KTGEAFESAG VVDDKGKVYL SGLSEAGKLK AQWGTNSQCY ADYKLPLKKG MSGIFLTRAV
     CM