ID   AGGR_ECOLX              Reviewed;         265 AA.
AC   P43464;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Transcriptional activator AggR {ECO:0000303|PubMed:7913930};
DE   AltName: Full=AAF/I regulatory protein;
GN   Name=aggR;
OS   Escherichia coli.
OG   Plasmid unnamed.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=O3:H2 / 17-2 / EAggEC;
RX   PubMed=7913930; DOI=10.1128/jb.176.15.4691-4699.1994;
RA   Nataro J.P., Yikang D., Yingkang D., Walker K.;
RT   "AggR, a transcriptional activator of aggregative adherence fimbria I
RT   expression in enteroaggregative Escherichia coli.";
RL   J. Bacteriol. 176:4691-4699(1994).
CC   -!- FUNCTION: Transcriptional activator of aggregative adherence fimbria I
CC       expression in enteroaggregative E.coli. {ECO:0000269|PubMed:7913930}.
CC   -!- DISRUPTION PHENOTYPE: Loss of autoagglutination, hemagglutination and
CC       aggregative adherence to human epithelial HEp-2 cells, loss of
CC       aggregative adherence fimbria I expression.
CC       {ECO:0000269|PubMed:7913930}.
CC   -!- MISCELLANEOUS: Encoded on an unnamed 60MDa plasmid.
CC       {ECO:0000269|PubMed:7913930}.
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DR   EMBL; Z32523; CAA83535.1; -; Genomic_DNA.
DR   EMBL; Z18751; CAA79242.1; -; Genomic_DNA.
DR   PIR; S32735; S32735.
DR   RefSeq; WP_000769457.1; NZ_WSWO01000087.1.
DR   RefSeq; YP_006940465.1; NC_019000.1.
DR   AlphaFoldDB; P43464; -.
DR   SMR; P43464; -.
DR   OMA; FQISHRC; -.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Plasmid; Transcription; Transcription regulation.
FT   CHAIN           1..265
FT                   /note="Transcriptional activator AggR"
FT                   /id="PRO_0000194496"
FT   DOMAIN          164..261
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        181..202
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        228..251
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   265 AA;  30690 MW;  E29828954072075A CRC64;
     MKLKQNIEKE IIKINNIRIH QYTVLYTSNC TIDVYTKEGS NTYLRNELIF LERGINISVR
     LQKKKSTVNP FIAIRLSSDT LRRLKDALMI IYGISKVDAC SCPNWSKGII VADADDSVLD
     TFKSIDHNDD SRITSDLIYL ISKIENNRKI IESIYISAVS FFSDKVRNTI EKDLSKRWTL
     AIIADEFNVS EITIRKRLES EYITFNQILM QSRMSKAALL LLDNSYQISQ ISNMIGFSST
     SYFIRLFVKH FGITPKQFLT YFKSQ