ID   AGH_ARMVU               Reviewed;         144 AA.
AC   Q9U8R2;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Androgenic gland hormone;
DE   AltName: Full=Arv-AGH;
DE   Contains:
DE     RecName: Full=Androgenic gland hormone B chain;
DE   Contains:
DE     RecName: Full=Androgenic gland hormone A chain;
DE   Flags: Precursor;
OS   Armadillidium vulgare (Pillbug) (Pill woodlouse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Peracarida; Isopoda; Oniscidea; Crinocheta;
OC   Armadillidiidae; Armadillidium.
OX   NCBI_TaxID=13347;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Androgenic gland;
RX   PubMed=10529379; DOI=10.1006/bbrc.1999.1522;
RA   Okuno A., Hasegawa Y., Ohira T., Katakura Y., Nagasawa H.;
RT   "Characterization and cDNA cloning of androgenic gland hormone of the
RT   terrestrial isopod Armadillidium vulgare.";
RL   Biochem. Biophys. Res. Commun. 264:419-423(1999).
RN   [2]
RP   PARTIAL PROTEIN SEQUENCE, AND GLYCOSYLATION AT ASN-133.
RC   TISSUE=Androgenic gland;
RX   PubMed=10411634; DOI=10.1046/j.1432-1327.1999.00442.x;
RA   Martin G., Sorokine O., Moniatte M., Bulet P., Hetru C., van Dorsselaer A.;
RT   "The structure of a glycosylated protein hormone responsible for sex
RT   determination in the isopod, Armadillidium vulgare.";
RL   Eur. J. Biochem. 262:727-736(1999).
CC   -!- FUNCTION: Controls sex differentiation and the formation of male
CC       appendages, spermatogenesis, pigmentation, and male specific behavior.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Androgenic gland.
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DR   EMBL; AB029615; BAA86893.1; -; mRNA.
DR   PIR; JC7121; JC7121.
DR   AlphaFoldDB; Q9U8R2; -.
DR   SMR; Q9U8R2; -.
DR   GlyConnect; 51; 3 N-Linked glycans (1 site).
DR   PRIDE; Q9U8R2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007548; P:sex differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR020382; AGH.
DR   Pfam; PF17558; AGH; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Developmental protein; Differentiation;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone; Secreted;
KW   Sexual differentiation; Signal; Spermatogenesis.
FT   SIGNAL          1..21
FT   PEPTIDE         22..65
FT                   /note="Androgenic gland hormone B chain"
FT                   /id="PRO_0000020644"
FT   PROPEP          68..113
FT                   /note="C peptide"
FT                   /id="PRO_0000020645"
FT   PEPTIDE         116..144
FT                   /note="Androgenic gland hormone A chain"
FT                   /id="PRO_0000020646"
FT   CARBOHYD        133
FT                   /note="N-linked (GlcNAc...) (complex) asparagine"
FT                   /evidence="ECO:0000269|PubMed:10411634"
FT                   /id="CAR_000163"
FT   DISULFID        33..123
FT                   /note="Or C-33 with C-124"
FT   DISULFID        42..59
FT                   /note="Or C-44 with C-59"
FT   DISULFID        44..141
FT                   /note="Or C-42 with C-141"
FT   DISULFID        124..132
FT                   /note="Or C-123 with C-132"
SQ   SEQUENCE   144 AA;  16893 MW;  ED1541134628500B CRC64;
     MKGLVILVSL MCLALYNRIC AYQVRGMRSD VLCGDIRFTV QCICNELGYF PTERLDKPCP
     WPNREKRSAP EDELAFEDYE DQDYFHPRAL SIPSEIEHDN EKESDAFSIL SRGKREIAFY
     QECCNIRTEH KCNRTTVSLY CRTY