ID   AGH_PORDI               Reviewed;         146 AA.
AC   Q86SA8;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Androgenic gland hormone;
DE   AltName: Full=Pod-AGH;
DE   Contains:
DE     RecName: Full=Androgenic gland hormone B chain;
DE   Contains:
DE     RecName: Full=Androgenic gland hormone A chain;
DE   Flags: Precursor;
GN   Name=AGH;
OS   Porcellio dilatatus (Woodlouse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Peracarida; Isopoda; Oniscidea; Crinocheta;
OC   Porcellionidae; Porcellio.
OX   NCBI_TaxID=96809;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Androgenic gland;
RX   PubMed=12560604; DOI=10.2108/zsj.20.75;
RA   Ohira T., Hasegawa Y., Tominaga S., Okuno A., Nagasawa H.;
RT   "Molecular cloning and expression analysis of cDNAs encoding androgenic
RT   gland hormone precursors from two porcellionidae species, Porcellio scaber
RT   and P. dilatatus.";
RL   Zool. Sci. 20:75-81(2003).
CC   -!- FUNCTION: Controls sex differentiation and the formation of male
CC       appendages, spermatogenesis, pigmentation, and male specific behavior.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Androgenic gland.
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DR   EMBL; AB089811; BAC57013.1; -; mRNA.
DR   AlphaFoldDB; Q86SA8; -.
DR   SMR; Q86SA8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007548; P:sex differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR020382; AGH.
DR   Pfam; PF17558; AGH; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Developmental protein; Differentiation;
KW   Disulfide bond; Glycoprotein; Hormone; Secreted; Sexual differentiation;
KW   Signal; Spermatogenesis.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         22..65
FT                   /note="Androgenic gland hormone B chain"
FT                   /id="PRO_0000020647"
FT   PROPEP          68..113
FT                   /note="C peptide"
FT                   /id="PRO_0000020648"
FT   PEPTIDE         116..146
FT                   /note="Androgenic gland hormone A chain"
FT                   /id="PRO_0000020649"
FT   CARBOHYD        133
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        33..123
FT                   /note="Or C-33 with C-124"
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..59
FT                   /note="Or C-44 with C-59"
FT                   /evidence="ECO:0000250"
FT   DISULFID        44..141
FT                   /note="Or C-42 with C-141"
FT                   /evidence="ECO:0000250"
FT   DISULFID        124..132
FT                   /note="Or C-123 with C-132"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   146 AA;  17425 MW;  906CC99361F8B124 CRC64;
     MKGLLFIISL LFLTLHQRVW AYQVEGMKSD VICADIRFTV HCICNELGRF PTARLTKPCP
     WPNRERRSTD DEDYLFEEDE DEEFFHPRAL SRPTAAKYDD EILEDEVSFH SRTKRDIAFH
     EECCNIRTEH KCNRTTVELY CRRYSP