AGH_PORSC
ID AGH_PORSC Reviewed; 145 AA.
AC Q8I7X1; Q86SA9;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 52.
DE RecName: Full=Androgenic gland hormone;
DE AltName: Full=Pos-AGH;
DE Contains:
DE RecName: Full=Androgenic gland hormone B chain;
DE Contains:
DE RecName: Full=Androgenic gland hormone A chain;
DE Flags: Precursor;
GN Name=AGH;
OS Porcellio scaber (Common rough woodlouse) (Oniscus granulatus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Peracarida; Isopoda; Oniscidea; Crinocheta;
OC Porcellionidae; Porcellio.
OX NCBI_TaxID=64697;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-32 AND 115-128, MASS
RP SPECTROMETRY, AND GLYCOSYLATION AT ASN-132.
RX PubMed=15081839; DOI=10.1016/j.ygcen.2004.01.015;
RA Greve P., Braquart-Varnier C., Strub J.-M., Felix C., van Dorsselaer A.,
RA Martin G.;
RT "The glycosylated androgenic hormone of the terrestrial isopod Porcellio
RT scaber (Crustacea).";
RL Gen. Comp. Endocrinol. 136:389-397(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Androgenic gland;
RX PubMed=12560604; DOI=10.2108/zsj.20.75;
RA Ohira T., Hasegawa Y., Tominaga S., Okuno A., Nagasawa H.;
RT "Molecular cloning and expression analysis of cDNAs encoding androgenic
RT gland hormone precursors from two porcellionidae species, Porcellio scaber
RT and P. dilatatus.";
RL Zool. Sci. 20:75-81(2003).
CC -!- FUNCTION: Controls sex differentiation and the formation of male
CC appendages, spermatogenesis, pigmentation, and male specific behavior.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Androgenic gland.
CC -!- MASS SPECTROMETRY: [Androgenic gland hormone B chain]: Mass=4966.8;
CC Method=MALDI; Evidence={ECO:0000269|PubMed:15081839};
CC -!- MASS SPECTROMETRY: [Androgenic gland hormone A chain]: Mass=5443;
CC Method=MALDI; Evidence={ECO:0000269|PubMed:15081839};
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DR EMBL; AY169973; AAO11675.1; -; mRNA.
DR EMBL; AB089810; BAC57012.1; -; mRNA.
DR AlphaFoldDB; Q8I7X1; -.
DR iPTMnet; Q8I7X1; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007548; P:sex differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR020382; AGH.
DR Pfam; PF17558; AGH; 1.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Developmental protein; Differentiation;
KW Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone; Secreted;
KW Sexual differentiation; Signal; Spermatogenesis.
FT SIGNAL 1..21
FT /evidence="ECO:0000269|PubMed:15081839"
FT PEPTIDE 22..65
FT /note="Androgenic gland hormone B chain"
FT /id="PRO_0000020650"
FT PROPEP 68..112
FT /note="C peptide"
FT /id="PRO_0000020651"
FT PEPTIDE 115..145
FT /note="Androgenic gland hormone A chain"
FT /id="PRO_0000020652"
FT CARBOHYD 132
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:15081839"
FT DISULFID 33..122
FT /note="Or C-33 with C-124"
FT /evidence="ECO:0000250"
FT DISULFID 42..59
FT /note="Or C-44 with C-59"
FT /evidence="ECO:0000250"
FT DISULFID 44..140
FT /note="Or C-42 with C-141"
FT /evidence="ECO:0000250"
FT DISULFID 123..131
FT /note="Or C-123 with C-132"
FT /evidence="ECO:0000250"
FT CONFLICT 97
FT /note="S -> N (in Ref. 2; BAC57012)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 145 AA; 16973 MW; 4E5135942DE86694 CRC64;
MKGLLFIVSL LCLTLHQRVW AYQVIGMKSD VICADIRFTV HCICNELGLF PTSRLSKPCP
WPNRGRRSAD DEDYLFEEDE DDEFFHPRAL SPPAAKSGDE RLEDEVSFHS RSKRDIAFHE
ECCNIRTEHK CNKTTVELYC RRYTR
