ID   AGI6_TRYBB              Reviewed;         243 AA.
AC   Q26768;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=I/6 autoantigen;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=427;
RX   PubMed=9127738;
RA   Detmer E., Hemphill A., Mueller N., Seebeck T.;
RT   "The Trypanosoma brucei autoantigen I/6 is an internally repetitive
RT   cytoskeletal protein.";
RL   Eur. J. Cell Biol. 72:378-384(1997).
CC   -!- FUNCTION: Microtubule-associated protein that may be involved in cross-
CC       linking microtubules.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
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DR   EMBL; X96554; CAA65390.1; -; mRNA.
DR   AlphaFoldDB; Q26768; -.
DR   GO; GO:0030863; C:cortical cytoskeleton; IDA:GeneDB.
DR   GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IDA:GeneDB.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Microtubule; Repeat.
FT   CHAIN           1..243
FT                   /note="I/6 autoantigen"
FT                   /id="PRO_0000064497"
FT   DOMAIN          110..145
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   REPEAT          181..188
FT                   /note="1"
FT   REPEAT          189..196
FT                   /note="2"
FT   REPEAT          197..204
FT                   /note="3"
FT   REPEAT          205..212
FT                   /note="4"
FT   REPEAT          213..220
FT                   /note="5"
FT   REPEAT          221..228
FT                   /note="6"
FT   REGION          166..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          181..228
FT                   /note="6 X 8 AA tandem repeats"
FT   COMPBIAS        174..192
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        193..231
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   243 AA;  27765 MW;  F53C385A8FD8A835 CRC64;
     MLCPPDVAFE KRHFKRRDGN KVVPPSIALV AGLESGFLFK LSAVEDVARR GQFPGLLTED
     GFLLMCEESE HIRDAYAMAK HLVALAPDGI FTRATLQEAA GKVGSTQDTL SVEEVDALFN
     ALDSDNRGYV SVDEFMDALY GEEGREAMRE IRREYMRRKI EVEGEPSWRM RPTPKPTRKL
     RQKRKREQGQ KRKQGQRQKQ EQGQRQKREQ GQRQKQEQGQ KRKRERGGAQ RPPPPKQKAG
     CGC