AGL12_ARATH
ID AGL12_ARATH Reviewed; 211 AA.
AC Q38841; Q0WRV5; Q9SF79;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2001, sequence version 2.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Agamous-like MADS-box protein AGL12 {ECO:0000305};
DE AltName: Full=Protein XAANTAL 1 {ECO:0000303|PubMed:18203871};
GN Name=AGL12 {ECO:0000303|PubMed:12837945};
GN Synonyms=XAL1 {ECO:0000303|PubMed:18203871};
GN OrderedLocusNames=At1g71692 {ECO:0000312|Araport:AT1G71692};
GN ORFNames=F14O23.5, F26A9.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=7549482; DOI=10.2307/3870100;
RA Rounsley S.D., Ditta G.S., Yanofsky M.F.;
RT "Diverse roles for MADS box genes in Arabidopsis development.";
RL Plant Cell 7:1259-1269(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=11855641; DOI=10.1007/s004250100637;
RA Burgeff C., Liljegren S.J., Tapia-Lopez R., Yanofsky M.F.,
RA Alvarez-Buylla E.R.;
RT "MADS-box gene expression in lateral primordia, meristems and
RT differentiated tissues of Arabidopsis thaliana roots.";
RL Planta 214:365-372(2002).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12837945; DOI=10.1105/tpc.011544;
RA Parenicova L., de Folter S., Kieffer M., Horner D.S., Favalli C.,
RA Busscher J., Cook H.E., Ingram R.M., Kater M.M., Davies B., Angenent G.C.,
RA Colombo L.;
RT "Molecular and phylogenetic analyses of the complete MADS-box transcription
RT factor family in Arabidopsis: new openings to the MADS world.";
RL Plant Cell 15:1538-1551(2003).
RN [8]
RP FUNCTION, TISSUE SPECIFICITY, INDUCTION BY AUXIN, AND DISRUPTION PHENOTYPE.
RX PubMed=18203871; DOI=10.1104/pp.107.108647;
RA Tapia-Lopez R., Garcia-Ponce B., Dubrovsky J.G., Garay-Arroyo A.,
RA Perez-Ruiz R.V., Kim S.H., Acevedo F., Pelaz S., Alvarez-Buylla E.R.;
RT "An AGAMOUS-related MADS-box gene, XAL1 (AGL12), regulates root meristem
RT cell proliferation and flowering transition in Arabidopsis.";
RL Plant Physiol. 146:1182-1192(2008).
CC -!- FUNCTION: Probable transcription activator that regulates root
CC development by controlling cell proliferation in root meristem. May
CC mediate responses to auxin in the root. May act as promoter of the
CC flowering transition through up-regulation of SOC, FT and LFY.
CC {ECO:0000269|PubMed:18203871}.
CC -!- INTERACTION:
CC Q38841; Q9SZJ6: AGL21; NbExp=4; IntAct=EBI-621976, EBI-621986;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
CC -!- TISSUE SPECIFICITY: Preferentially expressed in roots (PubMed:7549482).
CC In root meristem, expressed in external cells of columella, lateral
CC root cap and atrichoblasts. In mature root, expressed in the central
CC cylinder (PubMed:11855641). Expressed in leaf vasculature, young floral
CC meristems and nectaries (PubMed:18203871).
CC {ECO:0000269|PubMed:11855641, ECO:0000269|PubMed:18203871,
CC ECO:0000269|PubMed:7549482}.
CC -!- DEVELOPMENTAL STAGE: During embryo development, expressed in a punctate
CC pattern from the globular stage to the torpedo stage.
CC {ECO:0000269|PubMed:11855641}.
CC -!- INDUCTION: By auxin in root phloem. {ECO:0000269|PubMed:18203871}.
CC -!- DISRUPTION PHENOTYPE: Retarded root growth, and altered root meristem
CC size and stem-cell patterning. Late flowering phenotype.
CC {ECO:0000269|PubMed:18203871}.
CC -!- MISCELLANEOUS: XAANTAL is the Mayan word for 'go slower' in recognition
CC of the retarded root growth phenotypes of xaantal mutants.
CC {ECO:0000303|PubMed:18203871}.
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DR EMBL; U20193; AAC49085.1; -; mRNA.
DR EMBL; AC012654; AAF43220.1; -; Genomic_DNA.
DR EMBL; AC016163; AAG51837.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35216.1; -; Genomic_DNA.
DR EMBL; BT006157; AAP04142.1; -; mRNA.
DR EMBL; BT008332; AAP37691.1; -; mRNA.
DR EMBL; BT008524; AAP40351.1; -; mRNA.
DR EMBL; AK228190; BAF00144.1; -; mRNA.
DR PIR; H96738; H96738.
DR RefSeq; NP_565022.1; NM_105825.3.
DR AlphaFoldDB; Q38841; -.
DR SMR; Q38841; -.
DR BioGRID; 28717; 9.
DR DIP; DIP-33766N; -.
DR IntAct; Q38841; 10.
DR STRING; 3702.AT1G71692.1; -.
DR PaxDb; Q38841; -.
DR PRIDE; Q38841; -.
DR EnsemblPlants; AT1G71692.1; AT1G71692.1; AT1G71692.
DR GeneID; 843497; -.
DR Gramene; AT1G71692.1; AT1G71692.1; AT1G71692.
DR KEGG; ath:AT1G71692; -.
DR Araport; AT1G71692; -.
DR TAIR; locus:2824536; AT1G71692.
DR eggNOG; KOG0014; Eukaryota.
DR HOGENOM; CLU_053053_0_3_1; -.
DR InParanoid; Q38841; -.
DR OMA; WIYHVRS; -.
DR OrthoDB; 1252066at2759; -.
DR PhylomeDB; Q38841; -.
DR PRO; PR:Q38841; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q38841; baseline and differential.
DR Genevisible; Q38841; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0048364; P:root development; IMP:TAIR.
DR GO; GO:0010228; P:vegetative to reproductive phase transition of meristem; IMP:TAIR.
DR CDD; cd00265; MADS_MEF2_like; 1.
DR Gene3D; 3.40.1810.10; -; 1.
DR InterPro; IPR033896; MADS_MEF2-like.
DR InterPro; IPR002487; TF_Kbox.
DR InterPro; IPR002100; TF_MADSbox.
DR InterPro; IPR036879; TF_MADSbox_sf.
DR Pfam; PF01486; K-box; 1.
DR Pfam; PF00319; SRF-TF; 1.
DR PRINTS; PR00404; MADSDOMAIN.
DR SMART; SM00432; MADS; 1.
DR SUPFAM; SSF55455; SSF55455; 1.
DR PROSITE; PS51297; K_BOX; 1.
DR PROSITE; PS00350; MADS_BOX_1; 1.
DR PROSITE; PS50066; MADS_BOX_2; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Flowering; Growth regulation; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..211
FT /note="Agamous-like MADS-box protein AGL12"
FT /id="PRO_0000199471"
FT DOMAIN 3..57
FT /note="MADS-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00251"
FT DOMAIN 95..185
FT /note="K-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00629"
FT CONFLICT 177
FT /note="E -> D (in Ref. 1; AAC49085)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 211 AA; 23919 MW; B606BD2622043D5A CRC64;
MARGKIQLKR IENPVHRQVT FCKRRTGLLK KAKELSVLCD AEIGVVIFSP QGKLFELATK
GTMEGMIDKY MKCTGGGRGS SSATFTAQEQ LQPPNLDPKD EINVLKQEIE MLQKGISYMF
GGGDGAMNLE ELLLLEKHLE YWISQIRSAK MDVMLQEIQS LRNKEGVLKN TNKYLLEKIE
ENNNSILDAN FAVMETNYSY PLTMPSEIFQ F
