ENHO_HUMAN
ID ENHO_HUMAN Reviewed; 76 AA.
AC Q6UWT2; Q8N666;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Adropin;
DE AltName: Full=Energy homeostasis-associated protein;
DE Flags: Precursor;
GN Name=ENHO; Synonyms=C9orf165; ORFNames=UNQ470/PRO830;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=19041763; DOI=10.1016/j.cmet.2008.10.011;
RA Kumar K.G., Trevaskis J.L., Lam D.D., Sutton G.M., Koza R.A.,
RA Chouljenko V.N., Kousoulas K.G., Rogers P.M., Kesterson R.A., Thearle M.,
RA Ferrante A.W. Jr., Mynatt R.L., Burris T.P., Dong J.Z., Halem H.A.,
RA Culler M.D., Heisler L.K., Stephens J.M., Butler A.A.;
RT "Identification of adropin as a secreted factor linking dietary
RT macronutrient intake with energy homeostasis and lipid metabolism.";
RL Cell Metab. 8:468-481(2008).
CC -!- FUNCTION: Involved in the regulation of glucose homeostasis and lipid
CC metabolism. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19041763}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6UWT2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UWT2-2; Sequence=VSP_026454;
CC -!- TISSUE SPECIFICITY: Expressed in liver and brain.
CC {ECO:0000269|PubMed:19041763}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ89021.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY358658; AAQ89021.1; ALT_FRAME; mRNA.
DR EMBL; BC022101; AAH22101.1; -; mRNA.
DR CCDS; CCDS43795.1; -. [Q6UWT2-1]
DR RefSeq; NP_940975.2; NM_198573.2. [Q6UWT2-1]
DR AlphaFoldDB; Q6UWT2; -.
DR SMR; Q6UWT2; -.
DR BioGRID; 131993; 1.
DR STRING; 9606.ENSP00000382675; -.
DR iPTMnet; Q6UWT2; -.
DR PhosphoSitePlus; Q6UWT2; -.
DR BioMuta; ENHO; -.
DR DMDM; 150438882; -.
DR PaxDb; Q6UWT2; -.
DR PeptideAtlas; Q6UWT2; -.
DR PRIDE; Q6UWT2; -.
DR Antibodypedia; 25484; 122 antibodies from 21 providers.
DR DNASU; 375704; -.
DR Ensembl; ENST00000399775.3; ENSP00000382675.2; ENSG00000168913.7. [Q6UWT2-1]
DR GeneID; 375704; -.
DR KEGG; hsa:375704; -.
DR MANE-Select; ENST00000399775.3; ENSP00000382675.2; NM_198573.3; NP_940975.2.
DR UCSC; uc003zun.2; human. [Q6UWT2-1]
DR CTD; 375704; -.
DR DisGeNET; 375704; -.
DR GeneCards; ENHO; -.
DR HGNC; HGNC:24838; ENHO.
DR HPA; ENSG00000168913; Group enriched (brain, choroid plexus).
DR MIM; 618556; gene.
DR neXtProt; NX_Q6UWT2; -.
DR OpenTargets; ENSG00000168913; -.
DR PharmGKB; PA164719156; -.
DR VEuPathDB; HostDB:ENSG00000168913; -.
DR eggNOG; ENOG502TDVU; Eukaryota.
DR GeneTree; ENSGT00390000001413; -.
DR HOGENOM; CLU_197690_0_0_1; -.
DR InParanoid; Q6UWT2; -.
DR OMA; QKSSHEG; -.
DR PhylomeDB; Q6UWT2; -.
DR TreeFam; TF338522; -.
DR PathwayCommons; Q6UWT2; -.
DR BioGRID-ORCS; 375704; 14 hits in 1061 CRISPR screens.
DR ChiTaRS; ENHO; human.
DR GenomeRNAi; 375704; -.
DR Pharos; Q6UWT2; Tbio.
DR PRO; PR:Q6UWT2; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q6UWT2; protein.
DR Bgee; ENSG00000168913; Expressed in amygdala and 134 other tissues.
DR Genevisible; Q6UWT2; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IEA:Ensembl.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IBA:GO_Central.
DR InterPro; IPR034461; Adropin.
DR PANTHER; PTHR38492; PTHR38492; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Secreted; Signal.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..76
FT /note="Adropin"
FT /id="PRO_0000292879"
FT REGION 41..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 48..76
FT /note="SPNSSPGPCPEKAPPPQKPSHEGSYLLQP -> RTQESACLELDPAAQSLAS
FT LAPIGAQWP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026454"
SQ SEQUENCE 76 AA; 7927 MW; 815301219DFE3921 CRC64;
MGAAISQGAL IAIVCNGLVG FLLLLLWVIL CWACHSRSAD VDSLSESSPN SSPGPCPEKA
PPPQKPSHEG SYLLQP
