ENHO_MOUSE
ID ENHO_MOUSE Reviewed; 76 AA.
AC Q8K1D8;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Adropin;
DE AltName: Full=Energy homeostasis-associated protein;
DE Flags: Precursor;
GN Name=Enho;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=19041763; DOI=10.1016/j.cmet.2008.10.011;
RA Kumar K.G., Trevaskis J.L., Lam D.D., Sutton G.M., Koza R.A.,
RA Chouljenko V.N., Kousoulas K.G., Rogers P.M., Kesterson R.A., Thearle M.,
RA Ferrante A.W. Jr., Mynatt R.L., Burris T.P., Dong J.Z., Halem H.A.,
RA Culler M.D., Heisler L.K., Stephens J.M., Butler A.A.;
RT "Identification of adropin as a secreted factor linking dietary
RT macronutrient intake with energy homeostasis and lipid metabolism.";
RL Cell Metab. 8:468-481(2008).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in the regulation of glucose homeostasis and lipid
CC metabolism. {ECO:0000269|PubMed:19041763}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19041763}.
CC -!- TISSUE SPECIFICITY: Expressed in liver and brain. Expressed in regions
CC of the brain involved in metabolic regulation.
CC {ECO:0000269|PubMed:19041763}.
CC -!- INDUCTION: In liver, up-regulated in mice fed a high-fat diet for 2
CC days, and down-regulated in obese mice fed a chronic high fat diet.
CC Also down-regulated in liver 4 hours after treatment with LXR agonist
CC GW3965. {ECO:0000269|PubMed:19041763}.
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DR EMBL; BC021944; AAH21944.1; -; mRNA.
DR CCDS; CCDS59655.1; -.
DR RefSeq; NP_081423.1; NM_027147.1.
DR AlphaFoldDB; Q8K1D8; -.
DR SMR; Q8K1D8; -.
DR STRING; 10090.ENSMUSP00000137902; -.
DR iPTMnet; Q8K1D8; -.
DR PhosphoSitePlus; Q8K1D8; -.
DR PaxDb; Q8K1D8; -.
DR PRIDE; Q8K1D8; -.
DR ProteomicsDB; 277874; -.
DR Antibodypedia; 25484; 122 antibodies from 21 providers.
DR Ensembl; ENSMUST00000127306; ENSMUSP00000137902; ENSMUSG00000028445.
DR GeneID; 69638; -.
DR KEGG; mmu:69638; -.
DR UCSC; uc008sjd.2; mouse.
DR CTD; 375704; -.
DR MGI; MGI:1916888; Enho.
DR VEuPathDB; HostDB:ENSMUSG00000028445; -.
DR eggNOG; ENOG502TDVU; Eukaryota.
DR GeneTree; ENSGT00390000001413; -.
DR HOGENOM; CLU_197690_0_0_1; -.
DR InParanoid; Q8K1D8; -.
DR OMA; QKSSHEG; -.
DR PhylomeDB; Q8K1D8; -.
DR BioGRID-ORCS; 69638; 0 hits in 70 CRISPR screens.
DR PRO; PR:Q8K1D8; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8K1D8; protein.
DR Bgee; ENSMUSG00000028445; Expressed in otolith organ and 210 other tissues.
DR Genevisible; Q8K1D8; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0005179; F:hormone activity; IMP:MGI.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEP:MGI.
DR InterPro; IPR034461; Adropin.
DR PANTHER; PTHR38492; PTHR38492; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..76
FT /note="Adropin"
FT /id="PRO_0000292880"
FT REGION 41..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 76 AA; 7927 MW; 815301219DFE3921 CRC64;
MGAAISQGAL IAIVCNGLVG FLLLLLWVIL CWACHSRSAD VDSLSESSPN SSPGPCPEKA
PPPQKPSHEG SYLLQP
