ID   ENK11_HUMAN             Reviewed;         191 AA.
AC   P61568;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2004, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Putative endogenous retrovirus group K member 11-1 Env polyprotein;
DE   AltName: Full=Envelope polyprotein;
DE   AltName: Full=HERV-K_1p13.3 provirus ancestral Env polyprotein;
DE   Includes:
DE     RecName: Full=Truncated surface protein;
DE              Short=SU;
GN   Name=ERVK11-1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Cerebellum, and Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- FUNCTION: Retroviral envelope proteins mediate receptor recognition and
CC       membrane fusion during early infection. Endogenous envelope proteins
CC       may have kept, lost or modified their original function during
CC       evolution (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Cerebellum and testis.
CC   -!- MISCELLANEOUS: Intergenic, closest flanking genes being GSTM1 and
CC       GSTM5.
CC   -!- SIMILARITY: Belongs to the beta type-B retroviral envelope protein
CC       family. HERV class-II K(HML-8) env subfamily. {ECO:0000305}.
CC   -!- CAUTION: Truncated; premature stop codon in the surface protein.
CC       {ECO:0000305}.
CC   -!- CAUTION: No predictable signal peptide. {ECO:0000305}.
CC   -!- CAUTION: Product of a dubious gene prediction. {ECO:0000305}.
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DR   EMBL; AK126628; BAC86619.1; -; mRNA.
DR   EMBL; AK128832; BAC87632.1; -; mRNA.
DR   AlphaFoldDB; P61568; -.
DR   BioMuta; HGNC:43647; -.
DR   DMDM; 47605619; -.
DR   PRIDE; P61568; -.
DR   GeneCards; ERVK11-1; -.
DR   HGNC; HGNC:43647; ERVK11-1.
DR   neXtProt; NX_P61568; -.
DR   PhylomeDB; P61568; -.
DR   Pharos; P61568; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; P61568; protein.
DR   InterPro; IPR029104; HERV-K_env.
DR   Pfam; PF13804; HERV-K_env_2; 1.
PE   5: Uncertain;
KW   Cleavage on pair of basic residues; ERV; Reference proteome;
KW   Transposable element; Viral envelope protein; Virion.
FT   CHAIN           1..191
FT                   /note="Putative endogenous retrovirus group K member 11-1
FT                   Env polyprotein"
FT                   /id="PRO_0000008529"
FT   REGION          1..191
FT                   /note="Truncated surface protein"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        27
FT                   /note="K -> R (in Ref. 1; BAC86619)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        34
FT                   /note="G -> R (in Ref. 1; BAC86619)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   191 AA;  21462 MW;  8DF9BC7BE28414AB CRC64;
     MPGAIDDHCP AQPGEEGTAF NVTMGYKYPP LCLGHATRCI HLETQVWAAY LLERLATGKW
     GHLVSGLSLC PLRQMKRGVI GDTPYFQYKP VGKLCPKNFE GPSKTLIWGD CVNSHAVVLK
     NDSYALVIDW APKGYLKNTC SSGGGEFLEA TYFISYWEDE DHHPTLHRWF GSFFTLKWED
     KDITLHPQGL V