ID   ENK5_HUMAN              Reviewed;         245 AA.
AC   Q9HDB8;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Endogenous retrovirus group K member 5 Env polyprotein;
DE   AltName: Full=Envelope polyprotein;
DE   AltName: Full=HERV-K(II) envelope protein;
DE   AltName: Full=HERV-K_3q12.3 provirus ancestral Env polyprotein;
DE   Includes:
DE     RecName: Full=Truncated surface protein;
DE              Short=SU;
GN   Name=ERVK-5; Synonyms=ERVK5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11401426; DOI=10.1006/geno.2001.6473;
RA   Sugimoto J., Matsuura N., Kinjo Y., Takasu N., Oda T., Jinno Y.;
RT   "Transcriptionally active HERV-K genes: identification, isolation, and
RT   chromosomal mapping.";
RL   Genomics 72:137-144(2001).
RN   [2]
RP   SUBGENOMIC RNA.
RX   PubMed=12629516; DOI=10.1038/sj.onc.1206241;
RA   Wang-Johanning F., Frost A.R., Jian B., Epp L., Lu D.W., Johanning G.L.;
RT   "Quantitation of HERV-K env gene expression and splicing in human breast
RT   cancer.";
RL   Oncogene 22:1528-1535(2003).
CC   -!- FUNCTION: Retroviral envelope proteins mediate receptor recognition and
CC       membrane fusion during early infection. Endogenous envelope proteins
CC       may have kept, lost or modified their original function during
CC       evolution.
CC   -!- SUBCELLULAR LOCATION: Virion.
CC   -!- TISSUE SPECIFICITY: Expressed in lung, placenta, testis, peripheral
CC       blood lymphocytes, and teratocarcinoma cell lines.
CC   -!- MISCELLANEOUS: Has a type 1 genome. The HERV-K(HML-2) family contains
CC       type 1 and type 2 genomes depending on the absence or presence of 292
CC       nucleotides at the 5'-end of the env gene resulting in Env proteins of
CC       distinct sizes. Despite their overall retroviral envelope structure
CC       HERV-K(HML-2) type 1 envelope proteins lack a predictable signal
CC       sequence. Subgenomic RNA transcripts coding for full-length envelope
CC       proteins have been detected for both type of genomes.
CC   -!- MISCELLANEOUS: Intergenic, closest flanking genes being RPL24 and
CC       FLJ23047.
CC   -!- SIMILARITY: Belongs to the beta type-B retroviral envelope protein
CC       family. HERV class-II K(HML-2) env subfamily. {ECO:0000305}.
CC   -!- CAUTION: No predictable signal peptide. {ECO:0000305}.
CC   -!- CAUTION: Truncated; premature stop codon in the surface protein.
CC       {ECO:0000305}.
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DR   EMBL; AB047240; BAB11760.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9HDB8; -.
DR   BioMuta; HGNC:13757; -.
DR   DMDM; 47605745; -.
DR   PeptideAtlas; Q9HDB8; -.
DR   PRIDE; Q9HDB8; -.
DR   GeneCards; ERVK-5; -.
DR   HGNC; HGNC:13757; ERVK-5.
DR   neXtProt; NX_Q9HDB8; -.
DR   PhylomeDB; Q9HDB8; -.
DR   Pharos; Q9HDB8; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   InterPro; IPR029104; HERV-K_env.
DR   Pfam; PF13804; HERV-K_env_2; 1.
PE   2: Evidence at transcript level;
KW   ERV; Reference proteome; Transposable element; Viral envelope protein;
KW   Virion.
FT   CHAIN           1..245
FT                   /note="Endogenous retrovirus group K member 5 Env
FT                   polyprotein"
FT                   /id="PRO_0000008518"
FT   REGION          1..245
FT                   /note="Truncated surface protein"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   245 AA;  27904 MW;  198F26D65ED56DDB CRC64;
     MVTPVTWMDN PIEVYVNDSV WVPGPTDDRC PAKPEEEGMM INISIVYRYP PICLGRAPGC
     LMPAVQNWLV EVPTVSPNSR FTYHMVSGMS LRPRVNYLQD FSYQRSLKFR PKGKPCPKEI
     PKESKNTEVL VWEECVANSA VILQNNEFGT IIDWAPRGQF YHNCSGQTQS CPSAQVSPAV
     DSDLTESLDK HKHKKLQSFY PWEWGEKGIS TPRPEIISPV SGPEHPELWR LWPDTTLEFG
     LEIKL