ENLYS_BPA51
ID ENLYS_BPA51 Reviewed; 341 AA.
AC Q38653;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 02-JUN-2021, entry version 80.
DE RecName: Full=Endolysin;
DE EC=3.5.1.28;
DE AltName: Full=Probable N-acetylmuramoyl-L-alanine amidase;
GN Name=PLY511;
OS Listeria phage A511 (Bacteriophage A511).
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Caudovirales; Herelleviridae; Jasinkavirinae; Pecentumvirus.
OX NCBI_TaxID=40523;
OH NCBI_TaxID=1639; Listeria monocytogenes.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8577256; DOI=10.1111/j.1365-2958.1995.tb02345.x;
RA Loessner M.J., Wendlinger G., Scherer S.;
RT "Heterogeneous endolysins in Listeria monocytogenes bacteriophages: a new
RT class of enzymes and evidence for conserved holin genes within the
RT siphoviral lysis cassettes.";
RL Mol. Microbiol. 16:1231-1241(1995).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolyzes the link between N-acetylmuramoyl residues and L-
CC amino acid residues in certain cell-wall glycopeptides.; EC=3.5.1.28;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed at about 20 minutes after infection.
CC -!- SIMILARITY: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
CC {ECO:0000305}.
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DR EMBL; X85010; CAA59368.1; -; Genomic_DNA.
DR PIR; S69802; S69802.
DR RefSeq; YP_001468459.1; NC_009811.2.
DR SMR; Q38653; -.
DR MEROPS; M15.950; -.
DR GeneID; 5601499; -.
DR KEGG; vg:5601499; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008745; F:N-acetylmuramoyl-L-alanine amidase activity; IEA:UniProtKB-EC.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR CDD; cd06583; PGRP; 1.
DR Gene3D; 3.40.80.10; -; 1.
DR InterPro; IPR036505; Amidase/PGRP_sf.
DR InterPro; IPR002502; Amidase_domain.
DR Pfam; PF01510; Amidase_2; 1.
DR SMART; SM00644; Ami_2; 1.
DR SUPFAM; SSF55846; SSF55846; 1.
PE 2: Evidence at transcript level;
KW Antimicrobial; Bacteriolytic enzyme; Hydrolase; Repeat; Secreted.
FT CHAIN 1..341
FT /note="Endolysin"
FT /id="PRO_0000164405"
FT DOMAIN 23..153
FT /note="N-acetylmuramoyl-L-alanine amidase"
FT /evidence="ECO:0000255"
FT REGION 175..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 341 AA; 36477 MW; 86C40B73F0FD8547 CRC64;
MVKYTVENKI IAGLPKGKLK GANFVIAHET ANSKSTIDNE VSYMTRNWKN AFVTHFVGGG
GRVVQVANVN YVSWGAGQYA NSYSYAQVEL CRTSNATTFK KDYEVYCQLL VDLAKKAGIP
ITLDSGSKTS DKGIKSHKWV ADKLGGTTHQ DPYAYLSSWG ISKAQFASDL AKVSGGGNTG
TAPAKPSTPA PKPSTPSTNL DKLGLVDYMN AKKMDSSYSN RDKLAKQYGI ANYSGTASQN
TTLLSKIKGG APKPSTPAPK PSTSTAKKIY FPPNKGNWSV YPTNKAPVKA NAIGAINPTK
FGGLTYTIQK DRGNGVYEIQ TDQFGRVQVY GAPSTGAVIK K