ID   ENLYS_BPML5             Reviewed;         292 AA.
AC   Q05285;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   23-FEB-2022, entry version 49.
DE   RecName: Full=Endolysin A {ECO:0000250|UniProtKB:O64203};
DE            EC=3.-.-.- {ECO:0000250|UniProtKB:O64203};
DE   AltName: Full=Gene 10 protein {ECO:0000305};
DE   AltName: Full=Gp10 {ECO:0000305};
DE   AltName: Full=Lysis protein {ECO:0000305};
DE   AltName: Full=Lysozyme {ECO:0000305};
GN   Name=10;
OS   Mycobacterium phage L5 (Mycobacteriophage L5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae; Fromanvirus.
OX   NCBI_TaxID=31757;
OH   NCBI_TaxID=1763; Mycobacterium.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8459766; DOI=10.1111/j.1365-2958.1993.tb01131.x;
RA   Hatfull G.F., Sarkis G.J.;
RT   "DNA sequence, structure and gene expression of mycobacteriophage L5: a
RT   phage system for mycobacterial genetics.";
RL   Mol. Microbiol. 7:395-405(1993).
CC   -!- FUNCTION: Endolysin that degrades host peptidoglycans and participates
CC       with the holin protein in the sequential events which lead to the
CC       programmed host cell lysis releasing the mature viral particles. Once
CC       the holin has permeabilized the host cell membrane, the endolysin can
CC       reach the periplasm and break down the peptidoglycan layer.
CC       {ECO:0000250|UniProtKB:O64203}.
CC   -!- SIMILARITY: Belongs to the L5likevirus endolysin A protein family.
CC       {ECO:0000305}.
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DR   EMBL; Z18946; CAA79386.1; -; Genomic_DNA.
DR   PIR; S30955; S30955.
DR   RefSeq; NP_039674.1; NC_001335.1.
DR   SMR; Q05285; -.
DR   GeneID; 2942936; -.
DR   KEGG; vg:2942936; -.
DR   Proteomes; UP000002123; Genome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Antimicrobial; Bacteriolytic enzyme; Cytolysis; Host cell lysis by virus;
KW   Hydrolase; Reference proteome; Viral release from host cell.
FT   CHAIN           1..292
FT                   /note="Endolysin A"
FT                   /id="PRO_0000164709"
SQ   SEQUENCE   292 AA;  32375 MW;  7AF40F050D7FC9ED CRC64;
     MTFTVTRERA QWVHDMARAR DGLPYAYGGA FTNNPRVSTD CSGLVLQTGA WYGGRTDWVG
     NRYGSTESFR LDHKIVYDLG FKRMPRGGPA ALPIKPVMLV GLQHGGGGVY SHTACTLMTM
     DHPGGPVKMS DRGVDWESHG NRNGVGVELY EGARAWNDPL FHDFWYLDAV LEDEGDDDEL
     ADPVLGKMIR EIHACLFNQT ASTSDLATPG EGAIWQLHQK IHSIDGMLHP IHAERRARAG
     DLGELHRIVL AAKGLGVKRD EVTKRVYQSI LADIERDNPE VLQRYIAERG GL