AGL19_ARATH
ID AGL19_ARATH Reviewed; 219 AA.
AC O82743;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Agamous-like MADS-box protein AGL19;
GN Name=AGL19; OrderedLocusNames=At4g22950; ORFNames=F7H19.130;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia; TISSUE=Root;
RX PubMed=11115127; DOI=10.1046/j.1365-313x.2000.00891.x;
RA Alvarez-Buylla E.R., Liljegren S.J., Pelaz S., Gold S.E., Burgeff C.,
RA Ditta G.S., Vergara-Silva F., Yanofsky M.F.;
RT "MADS-box gene evolution beyond flowers: expression in pollen, endosperm,
RT guard cells, roots and trichomes.";
RL Plant J. 24:457-466(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP TISSUE SPECIFICITY, AND GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=12949148; DOI=10.1093/molbev/msg216;
RA Kofuji R., Sumikawa N., Yamasaki M., Kondo K., Ueda K., Ito M., Hasebe M.;
RT "Evolution and divergence of the MADS-box gene family based on genome-wide
RT expression analyses.";
RL Mol. Biol. Evol. 20:1963-1977(2003).
RN [6]
RP TISSUE SPECIFICITY, AND GENE FAMILY.
RC STRAIN=cv. Columbia; TISSUE=Rosette leaf;
RX PubMed=12837945; DOI=10.1105/tpc.011544;
RA Parenicova L., de Folter S., Kieffer M., Horner D.S., Favalli C.,
RA Busscher J., Cook H.E., Ingram R.M., Kater M.M., Davies B., Angenent G.C.,
RA Colombo L.;
RT "Molecular and phylogenetic analyses of the complete MADS-box transcription
RT factor family in Arabidopsis: new openings to the MADS world.";
RL Plant Cell 15:1538-1551(2003).
RN [7]
RP INTERACTION WITH SOC1 AND AGL21.
RX PubMed=15805477; DOI=10.1105/tpc.105.031831;
RA de Folter S., Immink R.G.H., Kieffer M., Parenicova L., Henz S.R.,
RA Weigel D., Busscher M., Kooiker M., Colombo L., Kater M.M., Davies B.,
RA Angenent G.C.;
RT "Comprehensive interaction map of the Arabidopsis MADS Box transcription
RT factors.";
RL Plant Cell 17:1424-1433(2005).
RN [8]
RP FUNCTION, DISRUPTION PHENOTYPE, INDUCTION BY VERNALIZATION, TISSUE
RP SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=16778081; DOI=10.1101/gad.377206;
RA Schoenrock N., Bouveret R., Leroy O., Borghi L., Koehler C., Gruissem W.,
RA Hennig L.;
RT "Polycomb-group proteins repress the floral activator AGL19 in the FLC-
RT independent vernalization pathway.";
RL Genes Dev. 20:1667-1678(2006).
RN [9]
RP REVIEW.
RX PubMed=18390846; DOI=10.1093/jxb/ern070;
RA Alexandre C.M., Hennig L.;
RT "FLC or not FLC: the other side of vernalization.";
RL J. Exp. Bot. 59:1127-1135(2008).
CC -!- FUNCTION: Probable transcription factor that promotes flowering,
CC especially in response to vernalization by short periods of cold, in an
CC FLC-inpedendent manner. {ECO:0000269|PubMed:16778081}.
CC -!- SUBUNIT: Interacts with SOC1 and AGL21. {ECO:0000269|PubMed:15805477}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251,
CC ECO:0000269|PubMed:16778081}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in the outer layers of the root
CC meristem (lateral root cap and epidermis) and in the central cylinder
CC cells of mature roots. Also present in rosette leaves and seedlings
CC and, to a lesser extent, in cauline leaves and flowers. Enriched in
CC apices including the shoot apical meristem and developing leaf
CC primordia. {ECO:0000269|PubMed:11115127, ECO:0000269|PubMed:12837945,
CC ECO:0000269|PubMed:12949148, ECO:0000269|PubMed:16778081}.
CC -!- INDUCTION: Maintained at very low levels by the polycomb-group (PcG)
CC proteins MSI1, CLF, and EMF2 via histone methylation (H3K27me3).
CC Derepressed upon cold treatment (vernalization).
CC {ECO:0000269|PubMed:16778081}.
CC -!- DISRUPTION PHENOTYPE: Decreased response to vernalization, the
CC promotion of flowering by prolonged cold.
CC {ECO:0000269|PubMed:16778081}.
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DR EMBL; AF312664; AAG37901.1; -; mRNA.
DR EMBL; AL031018; CAA19810.1; -; Genomic_DNA.
DR EMBL; AL161558; CAB79250.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE84684.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM66284.1; -; Genomic_DNA.
DR EMBL; AY142523; AAN13066.1; -; mRNA.
DR PIR; T05126; T05126.
DR RefSeq; NP_001320037.1; NM_001341568.1.
DR RefSeq; NP_194026.1; NM_118424.2.
DR AlphaFoldDB; O82743; -.
DR SMR; O82743; -.
DR BioGRID; 13683; 2.
DR IntAct; O82743; 2.
DR STRING; 3702.AT4G22950.1; -.
DR PaxDb; O82743; -.
DR PRIDE; O82743; -.
DR EnsemblPlants; AT4G22950.1; AT4G22950.1; AT4G22950.
DR EnsemblPlants; AT4G22950.3; AT4G22950.3; AT4G22950.
DR GeneID; 828394; -.
DR Gramene; AT4G22950.1; AT4G22950.1; AT4G22950.
DR Gramene; AT4G22950.3; AT4G22950.3; AT4G22950.
DR KEGG; ath:AT4G22950; -.
DR Araport; AT4G22950; -.
DR TAIR; locus:2127213; AT4G22950.
DR eggNOG; KOG0014; Eukaryota.
DR HOGENOM; CLU_053053_0_4_1; -.
DR InParanoid; O82743; -.
DR OrthoDB; 1307109at2759; -.
DR PhylomeDB; O82743; -.
DR PRO; PR:O82743; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O82743; baseline and differential.
DR Genevisible; O82743; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0048510; P:regulation of timing of transition from vegetative to reproductive phase; IMP:TAIR.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0010048; P:vernalization response; IMP:TAIR.
DR CDD; cd00265; MADS_MEF2_like; 1.
DR Gene3D; 3.40.1810.10; -; 1.
DR InterPro; IPR033896; MADS_MEF2-like.
DR InterPro; IPR002487; TF_Kbox.
DR InterPro; IPR002100; TF_MADSbox.
DR InterPro; IPR036879; TF_MADSbox_sf.
DR Pfam; PF01486; K-box; 1.
DR Pfam; PF00319; SRF-TF; 1.
DR PRINTS; PR00404; MADSDOMAIN.
DR SMART; SM00432; MADS; 1.
DR SUPFAM; SSF55455; SSF55455; 1.
DR PROSITE; PS51297; K_BOX; 1.
DR PROSITE; PS00350; MADS_BOX_1; 1.
DR PROSITE; PS50066; MADS_BOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Flowering; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..219
FT /note="Agamous-like MADS-box protein AGL19"
FT /id="PRO_0000199477"
FT DOMAIN 1..61
FT /note="MADS-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00251"
FT DOMAIN 86..176
FT /note="K-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00629"
FT REGION 77..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 219 AA; 25049 MW; 663740DC9D5F4A7A CRC64;
MVRGKTEMKR IENATSRQVT FSKRRNGLLK KAFELSVLCD AEVALVIFSP RSKLYEFSSS
SIAATIERYQ RRIKEIGNNH KRNDNSQQAR DETSGLTKKI EQLEISKRKL LGEGIDACSI
EELQQLENQL DRSLSRIRAK KYQLLREEIE KLKAEERNLV KENKDLKEKW LGMGTATIAS
SQSTLSSSEV NIDDNMEVET GLFIGPPETR QSKKFPPQN
