AGL42_ARATH
ID AGL42_ARATH Reviewed; 210 AA.
AC Q9FIS1; C0Z253;
DT 13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 159.
DE RecName: Full=MADS-box protein AGL42;
DE AltName: Full=Protein AGAMOUS-LIKE 42;
DE AltName: Full=Protein FOREVER YOUNG FLOWER {ECO:0000303|PubMed:21689171};
GN Name=AGL42; OrderedLocusNames=At5g62165 {ECO:0000312|Araport:AT5G62165};
GN ORFNames=MTG10.20 {ECO:0000312|EMBL:BAB10179.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia; TISSUE=Flower;
RX PubMed=12837945; DOI=10.1105/tpc.011544;
RA Parenicova L., de Folter S., Kieffer M., Horner D.S., Favalli C.,
RA Busscher J., Cook H.E., Ingram R.M., Kater M.M., Davies B., Angenent G.C.,
RA Colombo L.;
RT "Molecular and phylogenetic analyses of the complete MADS-box transcription
RT factor family in Arabidopsis: new openings to the MADS world.";
RL Plant Cell 15:1538-1551(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT features of the regions of 1,013,767 bp covered by sixteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:297-308(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=18162590; DOI=10.1104/pp.107.112995;
RA Blakeslee J.J., Zhou H.W., Heath J.T., Skottke K.R., Barrios J.A.,
RA Liu S.Y., DeLong A.;
RT "Specificity of RCN1-mediated protein phosphatase 2A regulation in meristem
RT organization and stress response in roots.";
RL Plant Physiol. 146:539-553(2008).
RN [7]
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=21609362; DOI=10.1111/j.1365-313x.2011.04653.x;
RA Dorca-Fornell C., Gregis V., Grandi V., Coupland G., Colombo L.,
RA Kater M.M.;
RT "The Arabidopsis SOC1-like genes AGL42, AGL71 and AGL72 promote flowering
RT in the shoot apical and axillary meristems.";
RL Plant J. 67:1006-1017(2011).
RN [8]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=21689171; DOI=10.1111/j.1365-313x.2011.04677.x;
RA Chen M.K., Hsu W.H., Lee P.F., Thiruvengadam M., Chen H.I., Yang C.H.;
RT "The MADS box gene, FOREVER YOUNG FLOWER, acts as a repressor controlling
RT floral organ senescence and abscission in Arabidopsis.";
RL Plant J. 68:168-185(2011).
CC -!- FUNCTION: MADS-box transcription factor that acts with AGL71 and AGL72
CC in the control of flowering time. Promotes flowering at the shoot
CC apical and axillary meristems. Seems to act through a gibberellin-
CC dependent pathway. Interacts genetically with SOC1 and its expression
CC is directly regulated by SOC1 (PubMed:21609362). Plays a role in
CC controlling flower organ senescence and abscission by repressing
CC ethylene responses and regulating the expression of BOP2 and IDA
CC (PubMed:21689171). {ECO:0000269|PubMed:21609362,
CC ECO:0000269|PubMed:21689171}.
CC -!- INTERACTION:
CC Q9FIS1; Q9SZJ6: AGL21; NbExp=4; IntAct=EBI-622017, EBI-621986;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9FIS1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9FIS1-2; Sequence=VSP_058213;
CC -!- TISSUE SPECIFICITY: Expressed in quiescent center (QC) cells of root
CC tips (PubMed:18162590, PubMed:21689171). Expressed at the base of the
CC petiole of cotyledons and leaves, in flower buds, petals, sepals and
CC abscission zone of flowers and siliques. {ECO:0000269|PubMed:18162590,
CC ECO:0000269|PubMed:21689171}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the shoot apical meristem (SAM)
CC during the vegetative phase and the floral transition. After floral
CC transition, expressed in apical meristem (AM), inflorescence meristem
CC (IM) and floral primordia. {ECO:0000269|PubMed:21609362}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions. {ECO:0000269|PubMed:21609362}.
CC -!- MISCELLANEOUS: Plants over-expressing AGL42 have a significant delay of
CC leaf and flower senescence and a deficiency in flower abscission.
CC {ECO:0000269|PubMed:21689171}.
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DR EMBL; AY141213; AAN52777.1; -; mRNA.
DR EMBL; AB016880; BAB10179.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97572.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97573.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97574.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97575.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM68468.1; -; Genomic_DNA.
DR EMBL; AY054220; AAL06880.1; -; mRNA.
DR EMBL; AY065206; AAL38682.1; -; mRNA.
DR EMBL; AY066035; AAL47402.1; -; mRNA.
DR EMBL; AY096509; AAM20159.1; -; mRNA.
DR EMBL; AK318667; BAH56782.1; -; mRNA.
DR RefSeq; NP_001032123.1; NM_001037046.2. [Q9FIS1-1]
DR RefSeq; NP_001190593.1; NM_001203664.2. [Q9FIS1-2]
DR RefSeq; NP_001330222.1; NM_001345528.1. [Q9FIS1-2]
DR RefSeq; NP_568952.1; NM_125610.4. [Q9FIS1-1]
DR RefSeq; NP_851247.1; NM_180916.1. [Q9FIS1-1]
DR AlphaFoldDB; Q9FIS1; -.
DR SMR; Q9FIS1; -.
DR IntAct; Q9FIS1; 15.
DR STRING; 3702.AT5G62165.1; -.
DR PaxDb; Q9FIS1; -.
DR PRIDE; Q9FIS1; -.
DR EnsemblPlants; AT5G62165.1; AT5G62165.1; AT5G62165. [Q9FIS1-1]
DR EnsemblPlants; AT5G62165.10; AT5G62165.10; AT5G62165. [Q9FIS1-2]
DR EnsemblPlants; AT5G62165.2; AT5G62165.2; AT5G62165. [Q9FIS1-1]
DR EnsemblPlants; AT5G62165.3; AT5G62165.3; AT5G62165. [Q9FIS1-1]
DR EnsemblPlants; AT5G62165.4; AT5G62165.4; AT5G62165. [Q9FIS1-2]
DR GeneID; 836337; -.
DR Gramene; AT5G62165.1; AT5G62165.1; AT5G62165. [Q9FIS1-1]
DR Gramene; AT5G62165.10; AT5G62165.10; AT5G62165. [Q9FIS1-2]
DR Gramene; AT5G62165.2; AT5G62165.2; AT5G62165. [Q9FIS1-1]
DR Gramene; AT5G62165.3; AT5G62165.3; AT5G62165. [Q9FIS1-1]
DR Gramene; AT5G62165.4; AT5G62165.4; AT5G62165. [Q9FIS1-2]
DR KEGG; ath:AT5G62165; -.
DR Araport; AT5G62165; -.
DR TAIR; locus:505006709; AT5G62165.
DR eggNOG; KOG0014; Eukaryota.
DR InParanoid; Q9FIS1; -.
DR OMA; EMERYSQ; -.
DR OrthoDB; 1235442at2759; -.
DR PhylomeDB; Q9FIS1; -.
DR PRO; PR:Q9FIS1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FIS1; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009838; P:abscission; IMP:TAIR.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0080187; P:floral organ senescence; IMP:TAIR.
DR GO; GO:0010150; P:leaf senescence; IMP:TAIR.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0009909; P:regulation of flower development; IMP:TAIR.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00265; MADS_MEF2_like; 1.
DR Gene3D; 3.40.1810.10; -; 1.
DR InterPro; IPR033896; MADS_MEF2-like.
DR InterPro; IPR002487; TF_Kbox.
DR InterPro; IPR002100; TF_MADSbox.
DR InterPro; IPR036879; TF_MADSbox_sf.
DR Pfam; PF01486; K-box; 1.
DR Pfam; PF00319; SRF-TF; 1.
DR PRINTS; PR00404; MADSDOMAIN.
DR SMART; SM00432; MADS; 1.
DR SUPFAM; SSF55455; SSF55455; 1.
DR PROSITE; PS51297; K_BOX; 1.
DR PROSITE; PS00350; MADS_BOX_1; 1.
DR PROSITE; PS50066; MADS_BOX_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; Differentiation; DNA-binding;
KW Flowering; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..210
FT /note="MADS-box protein AGL42"
FT /id="PRO_0000436027"
FT DOMAIN 1..61
FT /note="MADS-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00251"
FT DOMAIN 87..177
FT /note="K-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00629"
FT VAR_SEQ 142..155
FT /note="Missing (in isoform 2)"
FT /id="VSP_058213"
SQ SEQUENCE 210 AA; 24673 MW; 77B19EA3F8E8DBB1 CRC64;
MVRGKIEMKK IENATSRQVT FSKRRNGLLK KAYELSVLCD AQLSLIIFSQ RGRLYEFSSS
DMQKTIERYR KYTKDHETSN HDSQIHLQQL KQEASHMITK IELLEFHKRK LLGQGIASCS
LEELQEIDSQ LQRSLGKVRE RKAQLFKEQL EKLKAKEKQL LEENVKLHQK NVINPWRGSS
TDQQQEKYKV IDLNLEVETD LFIGLPNRNC
