AGL62_ARATH
ID AGL62_ARATH Reviewed; 299 AA.
AC Q9FKK2; Q7X9H7;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Agamous-like MADS-box protein AGL62;
GN Name=AGL62; OrderedLocusNames=At5g60440; ORFNames=MUF9.24;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=12837945; DOI=10.1105/tpc.011544;
RA Parenicova L., de Folter S., Kieffer M., Horner D.S., Favalli C.,
RA Busscher J., Cook H.E., Ingram R.M., Kater M.M., Davies B., Angenent G.C.,
RA Colombo L.;
RT "Molecular and phylogenetic analyses of the complete MADS-box transcription
RT factor family in Arabidopsis: new openings to the MADS world.";
RL Plant Cell 15:1538-1551(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH AGL80,
RP DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX PubMed=18334668; DOI=10.1105/tpc.107.055137;
RA Kang I.-H., Steffen J.G., Portereiko M.F., Lloyd A., Drews G.N.;
RT "The AGL62 MADS domain protein regulates cellularization during endosperm
RT development in Arabidopsis.";
RL Plant Cell 20:635-647(2008).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP INTERACTION WITH AGL36; PHE1; PHE2; AGL80; AGL86; AGL90; AGL92 AND AGL97.
RX PubMed=15805477; DOI=10.1105/tpc.105.031831;
RA de Folter S., Immink R.G.H., Kieffer M., Parenicova L., Henz S.R.,
RA Weigel D., Busscher M., Kooiker M., Colombo L., Kater M.M., Davies B.,
RA Angenent G.C.;
RT "Comprehensive interaction map of the Arabidopsis MADS Box transcription
RT factors.";
RL Plant Cell 17:1424-1433(2005).
CC -!- FUNCTION: Probable transcription factor. Required for suppression of
CC cellularization and promotion of nuclear proliferation during early
CC endosperm development. The FERTILIZATION-INDEPENDENT SEED (FIS)
CC polycomb complex is required for suppression of ALG62 expression at the
CC end of the syncytial phase of endosperm development.
CC {ECO:0000269|PubMed:18334668}.
CC -!- SUBUNIT: Interacts with AGL36, PHE1/AGL37, PHE2/AGL38, AGL80, AGL86,
CC AGL90, AGL92 and AGL97. {ECO:0000269|PubMed:15805477,
CC ECO:0000269|PubMed:18334668}.
CC -!- INTERACTION:
CC Q9FKK2; Q7XJK8: PHE2; NbExp=4; IntAct=EBI-622140, EBI-622157;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9FKK2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9FKK2-2; Sequence=VSP_036317;
CC -!- TISSUE SPECIFICITY: Expressed in the endosperm but not in the embryo.
CC Detected in young siliques, roots, leaves, stems, young flowers and
CC anthers. {ECO:0000269|PubMed:18334668}.
CC -!- DEVELOPMENTAL STAGE: Expressed during the syncytial endosperm
CC development. {ECO:0000269|PubMed:18334668}.
CC -!- MISCELLANEOUS: Plants lacking AGL62 show a premature endosperm
CC cellularization and a seed-lethal phenotype.
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DR EMBL; AY141236; AAN52800.1; -; mRNA.
DR EMBL; EU493093; ACA25224.1; -; mRNA.
DR EMBL; AB011483; BAB08227.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97331.1; -; Genomic_DNA.
DR RefSeq; NP_200852.1; NM_125437.5. [Q9FKK2-1]
DR AlphaFoldDB; Q9FKK2; -.
DR SMR; Q9FKK2; -.
DR BioGRID; 21409; 9.
DR IntAct; Q9FKK2; 9.
DR STRING; 3702.AT5G60440.1; -.
DR PaxDb; Q9FKK2; -.
DR PRIDE; Q9FKK2; -.
DR ProteomicsDB; 245058; -. [Q9FKK2-1]
DR EnsemblPlants; AT5G60440.1; AT5G60440.1; AT5G60440. [Q9FKK2-1]
DR GeneID; 836165; -.
DR Gramene; AT5G60440.1; AT5G60440.1; AT5G60440. [Q9FKK2-1]
DR KEGG; ath:AT5G60440; -.
DR Araport; AT5G60440; -.
DR TAIR; locus:2175188; AT5G60440.
DR eggNOG; KOG0014; Eukaryota.
DR HOGENOM; CLU_053053_5_4_1; -.
DR InParanoid; Q9FKK2; -.
DR OMA; EGMEMSQ; -.
DR OrthoDB; 1516449at2759; -.
DR PhylomeDB; Q9FKK2; -.
DR PRO; PR:Q9FKK2; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FKK2; baseline and differential.
DR Genevisible; Q9FKK2; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009960; P:endosperm development; IMP:TAIR.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:2000012; P:regulation of auxin polar transport; IMP:TAIR.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00265; MADS_MEF2_like; 1.
DR Gene3D; 3.40.1810.10; -; 1.
DR InterPro; IPR033896; MADS_MEF2-like.
DR InterPro; IPR002100; TF_MADSbox.
DR InterPro; IPR036879; TF_MADSbox_sf.
DR Pfam; PF00319; SRF-TF; 1.
DR PRINTS; PR00404; MADSDOMAIN.
DR SMART; SM00432; MADS; 1.
DR SUPFAM; SSF55455; SSF55455; 1.
DR PROSITE; PS50066; MADS_BOX_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..299
FT /note="Agamous-like MADS-box protein AGL62"
FT /id="PRO_0000363650"
FT DOMAIN 6..66
FT /note="MADS-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00251"
FT COILED 99..133
FT /evidence="ECO:0000255"
FT VAR_SEQ 88..107
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12837945"
FT /id="VSP_036317"
SQ SEQUENCE 299 AA; 34588 MW; 805E99B733D3D9BF CRC64;
MVKKSKGRQK IEMVKMKNES NLQVTFSKRR SGLFKKASEL CTLCGAEVAI VVFSPGRKVF
SFGHPNVDSV IDRFINNNPL PPHQHNNMQL RETRRNSIVQ DLNNHLTQVL SQLETEKKKY
DELKKIREKT KALGNWWEDP VEELALSQLE GFKGNLENLK KVVTVEASRF FQANVPNFYV
GSSSNNAAFG IDDGSHINPD MDLFSQRRMM DINAFNYNQN QIHPNHALPP FGNNAYGINE
GFVPEYNVNF RPEYNPNQNQ IQNQNQVQIQ IQNQSFKREN ISEYEHHHGY PPQSRSDYY
