AGL63_ARATH
ID AGL63_ARATH Reviewed; 215 AA.
AC Q9SA07; Q7X9H3;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Agamous-like MADS-box protein AGL63 {ECO:0000305};
DE AltName: Full=Protein GORDITA {ECO:0000303|PubMed:20088901};
GN Name=AGL63 {ECO:0000303|PubMed:12837945};
GN Synonyms=GOA {ECO:0000303|PubMed:20088901};
GN OrderedLocusNames=At1g31140 {ECO:0000312|Araport:AT1G31140};
GN ORFNames=F28K20.7 {ECO:0000312|EMBL:AAD21695.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia; TISSUE=Flower;
RX PubMed=12837945; DOI=10.1105/tpc.011544;
RA Parenicova L., de Folter S., Kieffer M., Horner D.S., Favalli C.,
RA Busscher J., Cook H.E., Ingram R.M., Kater M.M., Davies B., Angenent G.C.,
RA Colombo L.;
RT "Molecular and phylogenetic analyses of the complete MADS-box transcription
RT factor family in Arabidopsis: new openings to the MADS world.";
RL Plant Cell 15:1538-1551(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH AGL16,
RP AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia; TISSUE=Flower, and Flower bud;
RX PubMed=20598091; DOI=10.1111/j.1365-313x.2010.04290.x;
RA Erdmann R., Gramzow L., Melzer R., Theissen G., Becker A.;
RT "GORDITA (AGL63) is a young paralog of the Arabidopsis thaliana B(sister)
RT MADS box gene ABS (TT16) that has undergone neofunctionalization.";
RL Plant J. 63:914-924(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA Takagi M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=20088901; DOI=10.1111/j.1365-313x.2010.04139.x;
RA Prasad K., Zhang X., Tobon E., Ambrose B.A.;
RT "The Arabidopsis B-sister MADS-box protein, GORDITA, represses fruit growth
RT and contributes to integument development.";
RL Plant J. 62:203-214(2010).
RN [7]
RP FUNCTION.
RX PubMed=27233529; DOI=10.1105/tpc.16.00041;
RA Xu W., Fiume E., Coen O., Pechoux C., Lepiniec L., Magnani E.;
RT "Endosperm and nucellus develop antagonistically in Arabidopsis seeds.";
RL Plant Cell 28:1343-1360(2016).
CC -!- FUNCTION: Probable transcription factor involved in the regulation of
CC fruit growth. Contributes to integument development. Controls organ
CC size via cell expansion (PubMed:20088901). Involved in the regulation
CC of longitudinal growth of the fruit evenly throughout the radial axis
CC (PubMed:20598091). Functions redundantly with TT16/AGL32 to repress
CC nucellus growth and promote its degeneration (PubMed:27233529).
CC {ECO:0000269|PubMed:20088901, ECO:0000269|PubMed:20598091,
CC ECO:0000269|PubMed:27233529}.
CC -!- SUBUNIT: Forms homodimer (PubMed:20598091). Interacts with AGL16
CC (PubMed:20598091). {ECO:0000269|PubMed:20598091}.
CC -!- INTERACTION:
CC Q9SA07; Q8LPR5: TCP4; NbExp=4; IntAct=EBI-622106, EBI-15192325;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9SA07-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9SA07-2; Sequence=VSP_058826;
CC -!- TISSUE SPECIFICITY: Expressed in bud pedicels, petals, anthers, style,
CC ovary, seeds and embryos. {ECO:0000269|PubMed:20088901,
CC ECO:0000269|PubMed:20598091}.
CC -!- MISCELLANEOUS: Plants over-expressing AGL63 are dwarf, have few rosette
CC leaves with a curly-leaf phenotype, and display small disorganized
CC floral structures and addition of carpel-like, resulting in small
CC abnormal siliques with few seed production.
CC {ECO:0000269|PubMed:20088901, ECO:0000269|PubMed:20598091}.
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DR EMBL; AY141243; AAN52807.1; -; mRNA.
DR EMBL; FR671367; CBW38506.1; -; mRNA.
DR EMBL; AC004793; AAD21695.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31316.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31317.1; -; Genomic_DNA.
DR EMBL; AB493489; BAH30327.1; -; mRNA.
DR PIR; A86437; A86437.
DR RefSeq; NP_001185120.1; NM_001198191.2. [Q9SA07-1]
DR RefSeq; NP_174399.2; NM_102852.3. [Q9SA07-2]
DR AlphaFoldDB; Q9SA07; -.
DR SMR; Q9SA07; -.
DR IntAct; Q9SA07; 10.
DR STRING; 3702.AT1G31140.2; -.
DR PaxDb; Q9SA07; -.
DR PRIDE; Q9SA07; -.
DR EnsemblPlants; AT1G31140.1; AT1G31140.1; AT1G31140. [Q9SA07-2]
DR EnsemblPlants; AT1G31140.2; AT1G31140.2; AT1G31140. [Q9SA07-1]
DR GeneID; 839999; -.
DR Gramene; AT1G31140.1; AT1G31140.1; AT1G31140. [Q9SA07-2]
DR Gramene; AT1G31140.2; AT1G31140.2; AT1G31140. [Q9SA07-1]
DR KEGG; ath:AT1G31140; -.
DR Araport; AT1G31140; -.
DR TAIR; locus:2029539; AT1G31140.
DR eggNOG; KOG0014; Eukaryota.
DR InParanoid; Q9SA07; -.
DR OMA; TCQREVE; -.
DR PRO; PR:Q9SA07; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SA07; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0010154; P:fruit development; IMP:TAIR.
DR GO; GO:0048530; P:fruit morphogenesis; IMP:TAIR.
DR GO; GO:0080060; P:integument development; IMP:TAIR.
DR GO; GO:0030308; P:negative regulation of cell growth; IMP:CACAO.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0048510; P:regulation of timing of transition from vegetative to reproductive phase; IMP:TAIR.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0048316; P:seed development; IEA:InterPro.
DR CDD; cd00265; MADS_MEF2_like; 1.
DR Gene3D; 3.40.1810.10; -; 1.
DR InterPro; IPR031050; FBP24/AGL63/defh21-like.
DR InterPro; IPR033896; MADS_MEF2-like.
DR InterPro; IPR002487; TF_Kbox.
DR InterPro; IPR002100; TF_MADSbox.
DR InterPro; IPR036879; TF_MADSbox_sf.
DR PANTHER; PTHR11945:SF537; PTHR11945:SF537; 1.
DR Pfam; PF00319; SRF-TF; 1.
DR PRINTS; PR00404; MADSDOMAIN.
DR SMART; SM00432; MADS; 1.
DR SUPFAM; SSF55455; SSF55455; 1.
DR PROSITE; PS51297; K_BOX; 1.
DR PROSITE; PS50066; MADS_BOX_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; DNA-binding; Flowering;
KW Growth regulation; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..215
FT /note="Agamous-like MADS-box protein AGL63"
FT /id="PRO_0000439290"
FT DOMAIN 1..61
FT /note="MADS-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00251"
FT DOMAIN 90..178
FT /note="K-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00629"
FT REGION 143..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 88..89
FT /note="Missing (in isoform 2)"
FT /id="VSP_058826"
SQ SEQUENCE 215 AA; 25175 MW; 0A01C6EC589411BA CRC64;
MRKGKRVIKK IEEKIKRQVT FAKRKKSLIK KAYELSVLCD VHLGLIIFSH SNRLYDFCSN
STSMENLIMR YQKEKEGQTT AEHSFHSDQC SDCVKTKESM MREIENLKLN LQLYDGHGLN
LLTYDELLSF ELHLESSLQH ARARKSEFMH QQQQQQTDQK LKGKEKGQGS SWEQLMWQAE
RQMMTCQRQK DPAPANEGGV PFLRWGTTHR RSSPP
