ID   AGL6_ARATH              Reviewed;         252 AA.
AC   P29386;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   03-AUG-2022, entry version 159.
DE   RecName: Full=Agamous-like MADS-box protein AGL6;
GN   Name=AGL6; OrderedLocusNames=At2g45650; ORFNames=F17K2.18;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Landsberg erecta;
RX   PubMed=1672119; DOI=10.1101/gad.5.3.484;
RA   Ma H., Yanofsky M.F., Meyerowitz E.M.;
RT   "AGL1-AGL6, an Arabidopsis gene family with similarity to floral homeotic
RT   and transcription factor genes.";
RL   Genes Dev. 5:484-495(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   CHARACTERIZATION.
RX   PubMed=9418042; DOI=10.1046/j.1365-313x.1997.12050999.x;
RA   Fan H.-Y., Hu Y., Tudor M., Ma H.;
RT   "Specific interactions between the K domains of AG and AGLs, members of the
RT   MADS domain family of DNA binding proteins.";
RL   Plant J. 12:999-1010(1997).
RN   [5]
RP   INTERACTION WITH AGL15 AND AGL16.
RX   PubMed=15805477; DOI=10.1105/tpc.105.031831;
RA   de Folter S., Immink R.G.H., Kieffer M., Parenicova L., Henz S.R.,
RA   Weigel D., Busscher M., Kooiker M., Colombo L., Kater M.M., Davies B.,
RA   Angenent G.C.;
RT   "Comprehensive interaction map of the Arabidopsis MADS Box transcription
RT   factors.";
RL   Plant Cell 17:1424-1433(2005).
CC   -!- FUNCTION: Probable transcription factor. Forms a heterodimer via the K-
CC       box domain with AG, that could be involved in genes regulation during
CC       floral meristem development.
CC   -!- SUBUNIT: Forms a heterodimer with AGAMOUS. Interacts with AGL15 and
CC       AGL16. {ECO:0000269|PubMed:15805477}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Preferentially expressed in flowers.
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DR   EMBL; M55554; AAA79328.1; -; mRNA.
DR   EMBL; AC003680; AAC06173.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC10582.1; -; Genomic_DNA.
DR   PIR; F39534; F39534.
DR   RefSeq; NP_182089.1; NM_130127.2.
DR   AlphaFoldDB; P29386; -.
DR   SMR; P29386; -.
DR   BioGRID; 4509; 21.
DR   DIP; DIP-33737N; -.
DR   IntAct; P29386; 21.
DR   STRING; 3702.AT2G45650.1; -.
DR   PaxDb; P29386; -.
DR   PRIDE; P29386; -.
DR   ProteomicsDB; 244917; -.
DR   EnsemblPlants; AT2G45650.1; AT2G45650.1; AT2G45650.
DR   GeneID; 819173; -.
DR   Gramene; AT2G45650.1; AT2G45650.1; AT2G45650.
DR   KEGG; ath:AT2G45650; -.
DR   Araport; AT2G45650; -.
DR   TAIR; locus:2043600; AT2G45650.
DR   eggNOG; KOG0014; Eukaryota.
DR   HOGENOM; CLU_053053_0_2_1; -.
DR   InParanoid; P29386; -.
DR   OMA; FQDLWAN; -.
DR   OrthoDB; 1353656at2759; -.
DR   PhylomeDB; P29386; -.
DR   PRO; PR:P29386; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; P29386; baseline and differential.
DR   Genevisible; P29386; AT.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0048437; P:floral organ development; IMP:TAIR.
DR   GO; GO:0009911; P:positive regulation of flower development; IMP:TAIR.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0010228; P:vegetative to reproductive phase transition of meristem; IMP:TAIR.
DR   CDD; cd00265; MADS_MEF2_like; 1.
DR   Gene3D; 3.40.1810.10; -; 1.
DR   InterPro; IPR033896; MADS_MEF2-like.
DR   InterPro; IPR002487; TF_Kbox.
DR   InterPro; IPR002100; TF_MADSbox.
DR   InterPro; IPR036879; TF_MADSbox_sf.
DR   Pfam; PF01486; K-box; 1.
DR   Pfam; PF00319; SRF-TF; 1.
DR   PRINTS; PR00404; MADSDOMAIN.
DR   SMART; SM00432; MADS; 1.
DR   SUPFAM; SSF55455; SSF55455; 1.
DR   PROSITE; PS51297; K_BOX; 1.
DR   PROSITE; PS00350; MADS_BOX_1; 1.
DR   PROSITE; PS50066; MADS_BOX_2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Developmental protein; Differentiation; DNA-binding;
KW   Flowering; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..252
FT                   /note="Agamous-like MADS-box protein AGL6"
FT                   /id="PRO_0000199460"
FT   DOMAIN          3..57
FT                   /note="MADS-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00251"
FT   DOMAIN          86..176
FT                   /note="K-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00629"
FT   COILED          91..173
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   252 AA;  28745 MW;  F763A4A71515CF20 CRC64;
     MGRGRVEMKR IENKINRQVT FSKRRNGLLK KAYELSVLCD AEVALIIFSS RGKLYEFGSV
     GIESTIERYN RCYNCSLSNN KPEETTQSWC QEVTKLKSKY ESLVRTNRNL LGEDLGEMGV
     KELQALERQL EAALTATRQR KTQVMMEEME DLRKKERQLG DINKQLKIKF ETEGHAFKTF
     QDLWANSAAS VAGDPNNSEF PVEPSHPNVL DCNTEPFLQI GFQQHYYVQG EGSSVSKSNV
     AGETNFVQGW VL