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3MGA_HAEIN
ID   3MGA_HAEIN              Reviewed;         185 AA.
AC   P44321;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=DNA-3-methyladenine glycosylase;
DE            EC=3.2.2.20;
DE   AltName: Full=3-methyladenine-DNA glycosidase;
DE            Short=TAG;
GN   Name=tag; OrderedLocusNames=HI_0654;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-
CC       methyladenine from the damaged DNA polymer formed by alkylation
CC       lesions. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of alkylated DNA, releasing 3-methyladenine.;
CC         EC=3.2.2.20;
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DR   EMBL; L42023; AAC22313.1; -; Genomic_DNA.
DR   PIR; G64084; G64084.
DR   RefSeq; NP_438814.1; NC_000907.1.
DR   RefSeq; WP_005694489.1; NC_000907.1.
DR   AlphaFoldDB; P44321; -.
DR   SMR; P44321; -.
DR   STRING; 71421.HI_0654; -.
DR   EnsemblBacteria; AAC22313; AAC22313; HI_0654.
DR   KEGG; hin:HI_0654; -.
DR   PATRIC; fig|71421.8.peg.683; -.
DR   eggNOG; COG2818; Bacteria.
DR   HOGENOM; CLU_083758_1_0_6; -.
DR   OMA; YVAYHDT; -.
DR   PhylomeDB; P44321; -.
DR   BioCyc; HINF71421:G1GJ1-689-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0008725; F:DNA-3-methyladenine glycosylase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR   GO; GO:0006307; P:DNA dealkylation involved in DNA repair; IBA:GO_Central.
DR   InterPro; IPR005019; Adenine_glyco.
DR   InterPro; IPR011257; DNA_glycosylase.
DR   InterPro; IPR004597; Tag.
DR   Pfam; PF03352; Adenine_glyco; 1.
DR   SUPFAM; SSF48150; SSF48150; 1.
DR   TIGRFAMs; TIGR00624; tag; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Hydrolase; Metal-binding; Reference proteome; Zinc.
FT   CHAIN           1..185
FT                   /note="DNA-3-methyladenine glycosylase"
FT                   /id="PRO_0000194879"
FT   BINDING         5
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         19
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         176
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         180
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   185 AA;  21193 MW;  03AC41B636BD4321 CRC64;
     MTTRCPWVGE QSIYIDYHDK EWGKPEFDSQ KLFEKICLEG QQAGLSWITV LKKRESYREA
     FHQFDPKKIA KMTALDIDAC MQNSGLIRHR AKLEAIVKNA KAYLAMEKCG ENFSDFIWSF
     VNHKPIVNDV PDLRSVPTKT EVSKALSKAL KKRGFVFIGE TTCYAFMQSM GLVDDHLNDC
     PCKTS
 
 
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