ENSA_SALSA
ID ENSA_SALSA Reviewed; 115 AA.
AC B5XE27;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 03-AUG-2022, entry version 48.
DE RecName: Full=Alpha-endosulfine;
GN Name=ensa;
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
CC -!- FUNCTION: Protein phosphatase inhibitor that specifically inhibits
CC protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at
CC Ser-67 during mitosis, specifically interacts with ppp2r2d (PR55-delta)
CC and inhibits its activity, leading to inactivation of PP2A, an
CC essential condition to keep cyclin-B1-CDK1 activity high during M phase
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- PTM: Phosphorylation at Ser-65 by gwl during mitosis is essential for
CC interaction with ppp2r2d (PR55-delta) and subsequent inactivation of
CC PP2A. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the endosulfine family. {ECO:0000305}.
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DR EMBL; BT049296; ACI69097.1; -; mRNA.
DR RefSeq; NP_001135357.1; NM_001141885.1.
DR RefSeq; XP_014017931.1; XM_014162456.1.
DR RefSeq; XP_014056157.1; XM_014200682.1.
DR AlphaFoldDB; B5XE27; -.
DR STRING; 8030.ENSSSAP00000021471; -.
DR GeneID; 100196863; -.
DR GeneID; 106580912; -.
DR KEGG; sasa:100196863; -.
DR KEGG; sasa:106580912; -.
DR CTD; 100317933; -.
DR OMA; VWSTISY; -.
DR OrthoDB; 1494565at2759; -.
DR Proteomes; UP000087266; Chromosome ssa02.
DR Proteomes; UP000087266; Chromosome ssa05.
DR Bgee; ENSSSAG00000010602; Expressed in digestive tract and 16 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019212; F:phosphatase inhibitor activity; ISS:UniProtKB.
DR GO; GO:0051721; F:protein phosphatase 2A binding; ISS:UniProtKB.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0019888; F:protein phosphatase regulator activity; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; ISS:UniProtKB.
DR GO; GO:0000278; P:mitotic cell cycle; ISS:UniProtKB.
DR InterPro; IPR006760; Endosulphine.
DR PANTHER; PTHR10358; PTHR10358; 1.
DR Pfam; PF04667; Endosulfine; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cytoplasm; Mitosis; Phosphoprotein;
KW Protein phosphatase inhibitor; Reference proteome.
FT CHAIN 1..115
FT /note="Alpha-endosulfine"
FT /id="PRO_0000371565"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 65
FT /note="Phosphoserine; by GWL"
FT /evidence="ECO:0000250"
SQ SEQUENCE 115 AA; 12773 MW; 15599F9969BC4483 CRC64;
MSSENLSDTQ MEYEDEKQDS QEKNANLVKG EEVKLKAKYP GLGQKPGGSD FLMKRLQKGQ
KYFDSGDYNM AKAKMKNKQL PVAGPDKNLV TGDHIPTPQD LPQRRSSLVT SKLAG
