ENTR1_BOVIN
ID ENTR1_BOVIN Reviewed; 359 AA.
AC Q2KJD6;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Endosome-associated-trafficking regulator 1 {ECO:0000305};
DE AltName: Full=Serologically defined colon cancer antigen 3 homolog {ECO:0000250|UniProtKB:Q96C92};
GN Name=ENTR1 {ECO:0000250|UniProtKB:Q96C92}; Synonyms=SDCCAG3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Endosome-associated protein that plays a role in membrane
CC receptor sorting, cytokinesis and ciliogenesis. Involved in the
CC endosome-to-plasma membrane trafficking and recycling of SNX27-
CC retromer-dependent cargo proteins, such as GLUT1. Involved in the
CC regulation of cytokinesis; the function may involve PTPN13 and GIT1.
CC Plays a role in the formation of cilia. Involved in cargo protein
CC localization, such as PKD2, at primary cilia (By similarity). Involved
CC in the presentation of the tumor necrosis factor (TNF) receptor
CC TNFRSF1A on the cell surface, and hence in the modulation of the TNF-
CC induced apoptosis (By similarity). {ECO:0000250|UniProtKB:A2AIW0,
CC ECO:0000250|UniProtKB:Q96C92}.
CC -!- SUBUNIT: Found in a complex with ENTR1, PTPN13 and GIT1. Interacts with
CC PTPN13 (via the FERM domain). Interacts (via N-terminus) with GIT1 (via
CC N- and C-terminus); this interaction is direct. Interacts with NOD2.
CC Interacts (via N-terminus) with IFT88. Interacts with VPS35.
CC {ECO:0000250|UniProtKB:Q96C92}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A2AIW0}. Early
CC endosome {ECO:0000250|UniProtKB:Q96C92}. Endosome
CC {ECO:0000250|UniProtKB:Q96C92}. Recycling endosome
CC {ECO:0000250|UniProtKB:Q96C92}. Midbody {ECO:0000250|UniProtKB:Q96C92}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000250|UniProtKB:Q96C92}. Cytoplasm, cytoskeleton, cilium basal
CC body {ECO:0000250|UniProtKB:Q96C92}. Note=Colocalizes in a WASHC2-
CC dependent manner with the retromer CSC complex at endosomes. During
CC cytokinesis colocalized with PTPN13 at the midbody. Colocalizes with
CC IFT88 and gamma-tubulin at the basal body of primary cilia. Colocalizes
CC with IFT88 and pericentrin at the centrosome.
CC {ECO:0000250|UniProtKB:Q96C92}.
CC -!- DOMAIN: Tne N-terminal domain is necessary and sufficient for basal
CC body localization and ciliogenesis. {ECO:0000250|UniProtKB:Q96C92}.
CC -!- PTM: Phosphorylated. {ECO:0000250|UniProtKB:Q96C92}.
CC -!- SIMILARITY: Belongs to the ENTR1 family. {ECO:0000305}.
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DR EMBL; BC105395; AAI05396.1; -; mRNA.
DR RefSeq; NP_001039605.1; NM_001046140.1.
DR AlphaFoldDB; Q2KJD6; -.
DR SMR; Q2KJD6; -.
DR STRING; 9913.ENSBTAP00000049441; -.
DR PaxDb; Q2KJD6; -.
DR PRIDE; Q2KJD6; -.
DR GeneID; 513180; -.
DR KEGG; bta:513180; -.
DR CTD; 10807; -.
DR eggNOG; ENOG502QUJK; Eukaryota.
DR HOGENOM; CLU_051353_0_0_1; -.
DR InParanoid; Q2KJD6; -.
DR OrthoDB; 1429935at2759; -.
DR TreeFam; TF335840; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0030496; C:midbody; IBA:GO_Central.
DR GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0045724; P:positive regulation of cilium assembly; ISS:UniProtKB.
DR GO; GO:1903566; P:positive regulation of protein localization to cilium; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0032465; P:regulation of cytokinesis; IBA:GO_Central.
DR InterPro; IPR026757; ENTR1.
DR PANTHER; PTHR31259; PTHR31259; 2.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Cell projection; Cilium biogenesis/degradation;
KW Coiled coil; Cytoplasm; Cytoskeleton; Endosome; Phosphoprotein;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..359
FT /note="Endosome-associated-trafficking regulator 1"
FT /id="PRO_0000324284"
FT REGION 100..125
FT /note="Required for interaction with PTPN13"
FT /evidence="ECO:0000250|UniProtKB:Q96C92"
FT REGION 153..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 185..295
FT /evidence="ECO:0000255"
FT COMPBIAS 157..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 18
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96C92"
FT MOD_RES 74
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96C92"
FT MOD_RES 167
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96C92"
FT MOD_RES 171
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96C92"
SQ SEQUENCE 359 AA; 39871 MW; 141AE77C63EAE020 CRC64;
MAGYARRPGV TPLSRARSLV IPDDDKLGDL EAANPFSFKE FLKTKNLSLS KEDTDSRVYS
QEATRHSLGL DRTSPASQTV GYGLEYQQPF FEDPTGAGDL LDEDEDEEDG WNGAYLPSAM
EQTHSSRVAA STSPCSTYVS FFSNPSELVG PESLPPWTLS DSDSRISPTG SPSADFTAHG
ESLGDRHLRT LQISYEALKD ENSKLRRKLT EIQSFSETQT EMVRTLERKL EAKMIKEESD
YHDLESVVQQ VEQNLELMTK RAVKAENHVL KLRQEVSLLQ AQVSDFKREN EALRSGQGAS
LTVVKQNTDV ALQNLRVVMN NAHASIKQLV SGAETLNLVA EILKSIDRIS EIKDQGEES
