ID   ENTR1_DANRE             Reviewed;         311 AA.
AC   A2CE83;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Endosome-associated-trafficking regulator 1 {ECO:0000305};
DE   AltName: Full=Serologically defined colon cancer antigen 3 homolog {ECO:0000250|UniProtKB:Q96C92};
GN   Name=entr1 {ECO:0000250|UniProtKB:Q96C92}; Synonyms=sdccag3;
GN   ORFNames=si:dkey-1o2.3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- FUNCTION: Endosome-associated protein that plays a role in membrane
CC       receptor sorting, cytokinesis and ciliogenesis.
CC       {ECO:0000250|UniProtKB:A2AIW0, ECO:0000250|UniProtKB:Q96C92}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A2AIW0}. Early
CC       endosome {ECO:0000250|UniProtKB:Q96C92}. Endosome
CC       {ECO:0000250|UniProtKB:Q96C92}. Recycling endosome
CC       {ECO:0000250|UniProtKB:Q96C92}. Midbody {ECO:0000250|UniProtKB:Q96C92}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC       {ECO:0000250|UniProtKB:Q96C92}. Cytoplasm, cytoskeleton, cilium basal
CC       body {ECO:0000250|UniProtKB:Q96C92}.
CC   -!- SIMILARITY: Belongs to the ENTR1 family. {ECO:0000305}.
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DR   EMBL; CR381619; CAM15295.1; -; Genomic_DNA.
DR   AlphaFoldDB; A2CE83; -.
DR   SMR; A2CE83; -.
DR   STRING; 7955.ENSDARP00000121586; -.
DR   PaxDb; A2CE83; -.
DR   Ensembl; ENSDART00000142455; ENSDARP00000121586; ENSDARG00000095515.
DR   ZFIN; ZDB-GENE-060526-242; entr1.
DR   eggNOG; ENOG502QUJK; Eukaryota.
DR   GeneTree; ENSGT00390000000560; -.
DR   InParanoid; A2CE83; -.
DR   OMA; NDALQCG; -.
DR   PhylomeDB; A2CE83; -.
DR   PRO; PR:A2CE83; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000095515; Expressed in mature ovarian follicle and 20 other tissues.
DR   ExpressionAtlas; A2CE83; baseline.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR   GO; GO:0030496; C:midbody; IBA:GO_Central.
DR   GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:0045724; P:positive regulation of cilium assembly; ISS:UniProtKB.
DR   GO; GO:1903566; P:positive regulation of protein localization to cilium; ISS:UniProtKB.
DR   GO; GO:0032465; P:regulation of cytokinesis; IBA:GO_Central.
DR   InterPro; IPR026757; ENTR1.
DR   PANTHER; PTHR31259; PTHR31259; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell projection; Cilium biogenesis/degradation;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Endosome; Reference proteome.
FT   CHAIN           1..311
FT                   /note="Endosome-associated-trafficking regulator 1"
FT                   /id="PRO_0000324287"
FT   COILED          167..278
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   311 AA;  35359 MW;  43C0D60EBE6A1BAA CRC64;
     MSRHKSKKLI IEDDEPKQDE LNPFSFKEFI RNKNQPSCST EATEVYNGAC LVEQDYNTSI
     DFATKGPFFT DPSALCQPPE SEPDETWIES HQRSAIEGSP DFELCGASDI SAYSEQSSLC
     SDEREAAEWE LGQSDFLPKK HLSRISTGSY EGDEETSVID ISFHHKRGNA ENGTKNLQQL
     REENSLLRKQ VKELVRMSET DSRRIKQLTD EMHNKKLQEE KEANDLEAMV QSVEQNLQLM
     TKRAVKAENN ISKLKQEMLK LQGQLEDYKS ENERLRLGET AALATMRHNA QVASEYLNKA
     AQDAEISINS C