ID   ENTR1_XENTR             Reviewed;         346 AA.
AC   Q28GJ0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Endosome-associated-trafficking regulator 1 {ECO:0000305};
DE   AltName: Full=Serologically defined colon cancer antigen 3 homolog {ECO:0000250|UniProtKB:Q96C92};
GN   Name=entr1 {ECO:0000250|UniProtKB:Q96C92}; Synonyms=sdccag3;
GN   ORFNames=TEgg058n06.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endosome-associated protein that plays a role in membrane
CC       receptor sorting, cytokinesis and ciliogenesis.
CC       {ECO:0000250|UniProtKB:A2AIW0, ECO:0000250|UniProtKB:Q96C92}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A2AIW0}. Early
CC       endosome {ECO:0000250|UniProtKB:Q96C92}. Endosome
CC       {ECO:0000250|UniProtKB:Q96C92}. Recycling endosome
CC       {ECO:0000250|UniProtKB:Q96C92}. Midbody {ECO:0000250|UniProtKB:Q96C92}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC       {ECO:0000250|UniProtKB:Q96C92}. Cytoplasm, cytoskeleton, cilium basal
CC       body {ECO:0000250|UniProtKB:Q96C92}.
CC   -!- SIMILARITY: Belongs to the ENTR1 family. {ECO:0000305}.
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DR   EMBL; CR761370; CAJ81711.1; -; mRNA.
DR   EMBL; BC158294; AAI58295.1; -; mRNA.
DR   RefSeq; NP_001037937.1; NM_001044472.1.
DR   AlphaFoldDB; Q28GJ0; -.
DR   SMR; Q28GJ0; -.
DR   STRING; 8364.ENSXETP00000001653; -.
DR   PaxDb; Q28GJ0; -.
DR   GeneID; 733560; -.
DR   KEGG; xtr:733560; -.
DR   CTD; 10807; -.
DR   Xenbase; XB-GENE-986419; entr1.
DR   eggNOG; ENOG502QUJK; Eukaryota.
DR   HOGENOM; CLU_051353_0_0_1; -.
DR   InParanoid; Q28GJ0; -.
DR   OMA; NDALQCG; -.
DR   OrthoDB; 1429935at2759; -.
DR   PhylomeDB; Q28GJ0; -.
DR   TreeFam; TF335840; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000000747; Expressed in 2-cell stage embryo and 12 other tissues.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR   GO; GO:0030496; C:midbody; IBA:GO_Central.
DR   GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:0045724; P:positive regulation of cilium assembly; ISS:UniProtKB.
DR   GO; GO:1903566; P:positive regulation of protein localization to cilium; ISS:UniProtKB.
DR   GO; GO:0032465; P:regulation of cytokinesis; IBA:GO_Central.
DR   InterPro; IPR026757; ENTR1.
DR   PANTHER; PTHR31259; PTHR31259; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cell projection; Cilium biogenesis/degradation;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Endosome; Reference proteome.
FT   CHAIN           1..346
FT                   /note="Endosome-associated-trafficking regulator 1"
FT                   /id="PRO_0000324288"
FT   REGION          46..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          93..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          153..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          170..317
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        46..70
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   346 AA;  38301 MW;  5FA81193257BA7C0 CRC64;
     MSGSSKQPHA KGKTLIIEDD CEAEALDEAN PFSFKEFVKS QTFPGFVSSN SKRAFSKDSN
     QSTTQFRGPS ECPDGNLEFQ ETYFRDPTLY DDLQEDEDDD WSGSYHPSVI ENTHGPKVPS
     PAGTDGDESY GYGASDMSGD GLITGWQQAV LPSPPAGLHG KTQHRPDSTS DSEEGLRLLQ
     INCEELQEEN LHLKSKICKL KELNDSQNEK VRQLERKLEE RILEEQKEAQ DLESMVQQVE
     KNLQMMTKRA AKAEGNVTKL KQEMALLQIE LTTYKAENEA LRRGETAGMN AVKQNSNLAL
     ENLQKVVSGA QSSIKQLVAG AEALTLVAEL LRSIDKIAEI HNDGVP