AGN10_PAEDI
ID AGN10_PAEDI Reviewed; 404 AA.
AC A0A411PQP1;
DT 26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT 08-MAY-2019, sequence version 1.
DT 25-MAY-2022, entry version 11.
DE RecName: Full=Agnestins biosynthesis cluster transcription factor AgnL10 {ECO:0000303|PubMed:30746079};
DE AltName: Full=Agnestins biosynthesis cluster protein L10 {ECO:0000303|PubMed:30746079};
GN Name=Agn10 {ECO:0000303|PubMed:30746079};
OS Paecilomyces divaricatus (Penicillium divaricatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Thermoascaceae; Paecilomyces.
OX NCBI_TaxID=644132;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=K5013;
RX PubMed=30746079; DOI=10.1039/c8sc03778g;
RA Szwalbe A.J., Williams K., Song Z., de Mattos-Shipley K., Vincent J.L.,
RA Bailey A.M., Willis C.L., Cox R.J., Simpson T.J.;
RT "Characterisation of the biosynthetic pathway to agnestins A and B reveals
RT the reductive route to chrysophanol in fungi.";
RL Chem. Sci. 10:233-238(2019).
CC -!- FUNCTION: Transcription factor that regulates the expression of the
CC gene cluster that mediates the biosynthesis of agnestins, dihydroxy-
CC xanthone metabolites. {ECO:0000269|PubMed:30746079}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MH898872; QBG38878.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A411PQP1; -.
DR SMR; A0A411PQP1; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045122; P:aflatoxin biosynthetic process; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR013700; AflR.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF08493; AflR; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..404
FT /note="Agnestins biosynthesis cluster transcription factor
FT AgnL10"
FT /id="PRO_0000449022"
FT DNA_BIND 23..50
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 54..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 404 AA; 43424 MW; EBEDA911C80FE84C CRC64;
MQFPLASAHE DSPPAGLKLR DSCNRCAVSK IKCSKEKPAC ARCAKQDKVC EYSATKRAGR
KRGSRRHNNP VPSPTTQDLP TAAPSTCPTF LEDPETIPLS PRPPFESYPD LFPGIFSIGD
DPLIATPITL DTFSFPFDSF SASPISLPTL DVSDGDHLPD AVPLNHLNHP GDRTDVARAT
ALLASDHASA SSMDPAAGPQ RPPDEPSSGP ICGFIRALGL LNGLSSPAWP TSHHPGLDPR
PSSRSIMAEN EQTVRAISEM LHCQCFDDGY LLAILSMLIL KVLSSYATLL RQTPGPDGDG
VSWDNSTPPP GEQGAGVDGE DHCRTIAQQI LGQLHRVQRL VSILSQRFNI PGGRARTPDS
TAGPDLLSSI ETLFPVPGSM LEQMEGLLRK RLRTLSAEIV DILR