ID   AGN11_PAEDI             Reviewed;         684 AA.
AC   A0A411PQN2;
DT   26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT   08-MAY-2019, sequence version 1.
DT   25-MAY-2022, entry version 11.
DE   RecName: Full=Agnestins biosynthesis cluster transcription factor AgnL11 {ECO:0000303|PubMed:30746079};
DE   AltName: Full=Agnestins biosynthesis cluster protein L11 {ECO:0000303|PubMed:30746079};
GN   Name=AgnL11 {ECO:0000303|PubMed:30746079};
OS   Paecilomyces divaricatus (Penicillium divaricatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Thermoascaceae; Paecilomyces.
OX   NCBI_TaxID=644132;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=K5013;
RX   PubMed=30746079; DOI=10.1039/c8sc03778g;
RA   Szwalbe A.J., Williams K., Song Z., de Mattos-Shipley K., Vincent J.L.,
RA   Bailey A.M., Willis C.L., Cox R.J., Simpson T.J.;
RT   "Characterisation of the biosynthetic pathway to agnestins A and B reveals
RT   the reductive route to chrysophanol in fungi.";
RL   Chem. Sci. 10:233-238(2019).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of agnestins, dihydroxy-
CC       xanthone metabolites. {ECO:0000269|PubMed:30746079}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; MH898872; QBG38877.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A411PQN2; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil; DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..684
FT                   /note="Agnestins biosynthesis cluster transcription factor
FT                   AgnL11"
FT                   /id="PRO_0000449023"
FT   DNA_BIND        25..51
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          601..644
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          76..103
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        620..642
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   684 AA;  77285 MW;  C687CB01964B5CDE CRC64;
     MKRSFDASHG QLEKQSRPRQ VPTSCHFCRT KKLKCDRRFP CSNCRARRLS CVPFSDRSQA
     ASLDLPGAGP SSTVSNEELS ENINELKARL QRLEELISVN AEEKLDSKGP TSFVTSKGGY
     GEDVEASKSM NSLEMDAFEH QPLHSNSEER IAQLFASSFV SIIAPAIRLV IDQPTLSLLP
     SRKQAERLFD YFADQVVVFY YFIHVPTVRS MLDTVYTHLE NKRQPQHDHL ALLSTVFALS
     AYFGSSSSRF PFNGAEAKML CYRWISVAQQ ALCAANYIVQ PTVETLQSVI LIAAYLVPNL
     GSMSIFRVLM ASALQGALQL SLHQIDSPAN QRRRQNATVN WVDIESKRRI WWHLASTDWI
     VSFMSGPRCG TYMIHPKQMT VDLPTNVDDQ DIRPAGNYAQ PLENAPTDMT FSILRTRISV
     IFREIVDAAT DSGCLQEELP YDVVLAFDHR LHGIMADAPA CFRTDPRSSR APSRSPDLRL
     HRLIANALNR LHRPYLARGA RDPKYSYSRM VCLRTARSVI ELCKEMTGAN EEFQHVKMWT
     IVHPLFNSVL VLVMDYCLNR EEPRGDERKA EILEGFRLLE ACQEDSALAQ RGLQQMRQLL
     KGSASARKDK NPIHGDTDRA TPPGSSNLPQ HDKSSSSSPA PPVWPCLWTD PDLAPLETMD
     FDVDLDESQF EVLFRDFEGR HPMY