ENTS_SALTI
ID ENTS_SALTI Reviewed; 414 AA.
AC Q8Z8L4; Q7C8H2;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Enterobactin exporter EntS {ECO:0000255|HAMAP-Rule:MF_01436};
GN Name=entS {ECO:0000255|HAMAP-Rule:MF_01436};
GN OrderedLocusNames=STY0637, t2275;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Component of an export pathway for enterobactin.
CC {ECO:0000255|HAMAP-Rule:MF_01436}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01436}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01436}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. EntS (TC
CC 2.A.1.38) family. {ECO:0000255|HAMAP-Rule:MF_01436}.
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DR EMBL; AL513382; CAD05069.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO69877.1; -; Genomic_DNA.
DR RefSeq; NP_455169.1; NC_003198.1.
DR RefSeq; WP_001081657.1; NZ_WSUR01000008.1.
DR AlphaFoldDB; Q8Z8L4; -.
DR SMR; Q8Z8L4; -.
DR STRING; 220341.16501844; -.
DR PRIDE; Q8Z8L4; -.
DR EnsemblBacteria; AAO69877; AAO69877; t2275.
DR KEGG; stt:t2275; -.
DR KEGG; sty:STY0637; -.
DR PATRIC; fig|220341.7.peg.638; -.
DR eggNOG; COG0477; Bacteria.
DR HOGENOM; CLU_034180_11_0_6; -.
DR OMA; TPDDMRG; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0042931; F:enterobactin transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR HAMAP; MF_01436; MFS_EntS; 1.
DR InterPro; IPR023722; Enterobactin_exp_EntS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR010290; TM_effector.
DR Pfam; PF05977; MFS_3; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..414
FT /note="Enterobactin exporter EntS"
FT /id="PRO_0000227653"
FT TOPO_DOM 1..21
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 43..55
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 77..83
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 105..109
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 131..156
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 178
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 200..218
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 240..256
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 278..287
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 288..307
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 308..313
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 314..336
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 337..356
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 378
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT TOPO_DOM 400..414
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
SQ SEQUENCE 414 AA; 43103 MW; 372635B3C98E3A66 CRC64;
MNRQSWLLNL SLLKTHPAFR AVFLARFISI VSLGLLGVAV PVQIQMMTHS TWQVGLSVTL
TGGAMFIGLM VGGVLADRYE RKKVILLARG TCGIGFIGLC VNALLPEPSL LAIYLLGLWD
GFFASLGVTA LLAATPALVG RENLMQAGAI TMLTVRLGSV ISPMLGGILL ASGGVAWNYG
LAAAGTFITL LPLLTLPRLP VPPQPRENPF IALLAAFRFL LASPLIGGIA LLGGLVTMAS
AVRVLYPALA MSWQMSAAQI GLLYAAIPLG AAIGALTSGQ LAHSVRPGLI MLVSTVGSFL
AVGLFAIMPI WIAGVICLAL FGWLSAISSL LQYTLLQTQT PENMLGRMNG LWTAQNVTGD
AIGAALLGGL GAMMTPVASA SVSGFGLVII GLLLLLVLGE LRRFRQTPPV SDAG
