ID   ENT_ENTCO               Reviewed;         485 AA.
AC   P81007;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Cytolytic protein enterolobin;
OS   Enterolobium contortisiliquum (Pacara earpod tree) (Mimosa
OS   contortisiliqua).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Caesalpinioideae; mimosoid clade;
OC   Ingeae; Enterolobium.
OX   NCBI_TaxID=55671;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   STRAIN=cv. Morong; TISSUE=Seed;
RX   PubMed=9367525; DOI=10.1006/abbi.1997.0358;
RA   Fontes W., Sousa M.V., Aragao J.B., Morhy L.;
RT   "Determination of the amino acid sequence of the plant cytolysin
RT   enterolobin.";
RL   Arch. Biochem. Biophys. 347:201-207(1997).
RN   [2]
RP   PRELIMINARY PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Seed;
RX   PubMed=7710657; DOI=10.1007/bf01886950;
RA   Sousa M.V., Richardson M., Fontes W., Morhy L.;
RT   "Homology between the seed cytolysin enterolobin and bacterial
RT   aerolysins.";
RL   J. Protein Chem. 13:659-667(1994).
CC   -!- FUNCTION: Cytolytic protein with insecticidal activity. Acts as a pro-
CC       inflammatory agent.
CC   -!- SUBUNIT: Oligomerizes as a hexamer.
CC   -!- PTM: The N-terminus is blocked.
CC   -!- SIMILARITY: Belongs to the aerolysin family. {ECO:0000305}.
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DR   PIR; A57982; A57982.
DR   AlphaFoldDB; P81007; -.
DR   TCDB; 1.C.4.3.1; the aerolysin channel-forming toxin (aerolysin) family.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR005830; Aerolysn.
DR   SMART; SM00999; Aerolysin; 1.
PE   1: Evidence at protein level;
KW   Cytolysis; Direct protein sequencing; Disulfide bond.
FT   CHAIN           1..485
FT                   /note="Cytolytic protein enterolobin"
FT                   /id="PRO_0000194264"
FT   DISULFID        34..98
FT                   /evidence="ECO:0000250"
FT   DISULFID        183..189
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   485 AA;  54806 MW;  2DB66815A0F7FE8C CRC64;
     TQRDTLTKGM TQGQIVAGPD DTKIDQSIMD QGVCATIALP FDIHVAQSVK NVMFMFAWTQ
     KHGLAVNNLV ILGVPGYLNM WKRFGESTDE PSESSKRCCY EKPTDPVSGE IVTPAFDPAD
     EISEITHQEE SADIKPVRLL DARLLGYTWV TQNHSWIVAY SDEPIKDGNE VVTLRNIGNN
     NFCDALRKCT DKSACIHQYL QFAWNSFGDP TVRTRQVVFE VVGWADSDTT NNNSDTLFYR
     TTQADNWQVL TESKTNTIGL AEVDWFNFKY ETKQEVSIEI ARQTWTSTLN AGVSTVSRVP
     KVPIKVKINV DTFLKVLFAV YKADLYDIFL QFASVFKKGG NRQYWLNYTQ EPNTKSNYNH
     KIYNDKIRYL QEDVQVHPNE TQSKWWWWSF KKVALTTMTV VALTRFKASG INGQYISARQ
     FSGGETVSPY RLAAPFDSCL WRRSPNPLGT DGLKVALAHH PLAGASNRNK LRVSIPAQCI
     CSITA