ENV11_YEAST
ID ENV11_YEAST Reviewed; 860 AA.
AC P53246; D6VUK4;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Late endosome and vacuole interface protein 11;
GN Name=ENV11; OrderedLocusNames=YGR071C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION.
RX PubMed=12096123; DOI=10.1074/mcp.m100024-mcp200;
RA Wilson W.A., Wang Z., Roach P.J.;
RT "Systematic identification of the genes affecting glycogen storage in the
RT yeast Saccharomyces cerevisiae: implication of the vacuole as a determinant
RT of glycogen level.";
RL Mol. Cell. Proteomics 1:232-242(2002).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP DISRUPTION PHENOTYPE.
RX PubMed=19466415; DOI=10.1007/s00294-009-0251-0;
RA Watanabe M., Watanabe D., Nogami S., Morishita S., Ohya Y.;
RT "Comprehensive and quantitative analysis of yeast deletion mutants
RT defective in apical and isotropic bud growth.";
RL Curr. Genet. 55:365-380(2009).
RN [7]
RP DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=21912603; DOI=10.1371/journal.pone.0023696;
RA Ricarte F., Menjivar R., Chhun S., Soreta T., Oliveira L., Hsueh T.,
RA Serranilla M., Gharakhanian E.;
RT "A genome-wide immunodetection screen in S. cerevisiae uncovers novel genes
RT involved in lysosomal vacuole function and morphology.";
RL PLoS ONE 6:E23696-E23696(2011).
CC -!- FUNCTION: Involved in vacuolar processing and morphology.
CC {ECO:0000269|PubMed:12096123, ECO:0000269|PubMed:21912603}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14562095}.
CC -!- DISRUPTION PHENOTYPE: Exhibits cold sensitivity, a significant increase
CC in cells with fragmented vacuoles, internal accumulation of precursor
CC CPY, increased glycogen accumulation, and displays elongated buds.
CC {ECO:0000269|PubMed:19466415, ECO:0000269|PubMed:21912603}.
CC -!- MISCELLANEOUS: Present with 1050 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the VID22 family. {ECO:0000305}.
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DR EMBL; Z72856; CAA97073.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA08165.1; -; Genomic_DNA.
DR PIR; S64366; S64366.
DR RefSeq; NP_011585.3; NM_001181200.3.
DR AlphaFoldDB; P53246; -.
DR BioGRID; 33314; 108.
DR DIP; DIP-5521N; -.
DR IntAct; P53246; 6.
DR MINT; P53246; -.
DR STRING; 4932.YGR071C; -.
DR MaxQB; P53246; -.
DR PaxDb; P53246; -.
DR PRIDE; P53246; -.
DR EnsemblFungi; YGR071C_mRNA; YGR071C; YGR071C.
DR GeneID; 852962; -.
DR KEGG; sce:YGR071C; -.
DR SGD; S000003303; ENV11.
DR VEuPathDB; FungiDB:YGR071C; -.
DR eggNOG; ENOG502RKC9; Eukaryota.
DR GeneTree; ENSGT00940000176412; -.
DR HOGENOM; CLU_008135_0_0_1; -.
DR InParanoid; P53246; -.
DR OMA; TKVKCKH; -.
DR BioCyc; YEAST:G3O-30784-MON; -.
DR PRO; PR:P53246; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P53246; protein.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0005773; C:vacuole; IEA:GOC.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006624; P:vacuolar protein processing; IMP:SGD.
DR GO; GO:0007033; P:vacuole organization; IMP:SGD.
DR InterPro; IPR003656; Znf_BED.
DR Pfam; PF02892; zf-BED; 1.
DR PROSITE; PS50808; ZF_BED; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..860
FT /note="Late endosome and vacuole interface protein 11"
FT /id="PRO_0000202806"
FT ZN_FING 84..138
FT /note="BED-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT REGION 19..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 105
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT BINDING 108
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT BINDING 126
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT BINDING 131
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
SQ SEQUENCE 860 AA; 98109 MW; 308D65E456C8FF3B CRC64;
MNTALDDLHG DLVTLEDNEI INNSDHSSSH STSHEEEDEE EDDTEDIELI EKDGNKILSS
RIHPEDEIIN DGLNIWIPVQ MLKKNIAKFW SHFLAIEKKL TKVKCKHCGE ILTRSDASLT
KTFRSHLKTK HNISANKNFY SMNFTVGDSN LKNNTSSTEI TRRHGYDSLT FNSDQSFKCF
DIGKLQSSNY LSISQLVAIV IASENLPLNF FENVSFKSLL SKFHRIPPLT TNIIEESIIG
LSKSIDELIR RSISRNDTQL PFTIHLSDSK ESNQPLYLKY SREIRAQLSN LDLSHLISVN
FTELAGKRSL FSLQLFDNTN KVSKGLPLSI FVRKTTDIDI SVWQEQLNNL YSKYPGLQKS
VISITLPQSH YTMVLENRNS HNFTFHSGSV REIKYHTCIV SELLHCFLQP LFNVPTESML
SSFSVAKENH SGGSLLDSLI DFSHIDLSST ILGKICCLIE EVNLNDSLKS DFLLYCQNYT
QPNCNELTSI LSCNCDRFSA LKSILEKFAN LVPFFKSINS HLENESLSES DFRLINTVEE
TLRTFEQSIE YFASSAPLKF THTLVFIIKF ELYLTEIIRS FKFTKSKKPF EKILARLLKV
KDLYLLDDVN LIGAFLYPSI FQSKSLLNEI FGTTSVNKIV HNMTKIVLRY LKNFINITNF
RSSNSGGESG RNSGNNLLSD YEAIFMKESR DVELLCNTKL TAPLTEDSLL VQIIRDDLLR
YVNRIAHELP NAYHDYLNDN DISFDGSHFT KHELSEENDS NSGEWCLNPM EETFDIHIPI
SDSIWNNYIS SKNKIEVIDI LLQLLSVNST SSIRSELSSL TANQDFSTKL SEETIKIKLL
NSQFNLEKIN FHSGSIFDAC
