ID   AGN12_PAEDI             Reviewed;         433 AA.
AC   A0A411PQP0;
DT   26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT   08-MAY-2019, sequence version 1.
DT   25-MAY-2022, entry version 13.
DE   RecName: Full=Agnestins efflux protein AgnL12 {ECO:0000303|PubMed:30746079};
DE   AltName: Full=Agnestins biosynthesis cluster protein L12 {ECO:0000303|PubMed:30746079};
GN   Name=AgnL12 {ECO:0000303|PubMed:30746079};
OS   Paecilomyces divaricatus (Penicillium divaricatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Thermoascaceae; Paecilomyces.
OX   NCBI_TaxID=644132;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=K5013;
RX   PubMed=30746079; DOI=10.1039/c8sc03778g;
RA   Szwalbe A.J., Williams K., Song Z., de Mattos-Shipley K., Vincent J.L.,
RA   Bailey A.M., Willis C.L., Cox R.J., Simpson T.J.;
RT   "Characterisation of the biosynthetic pathway to agnestins A and B reveals
RT   the reductive route to chrysophanol in fungi.";
RL   Chem. Sci. 10:233-238(2019).
CC   -!- FUNCTION: Efflux pump that may be involved in the secretion of
CC       agnestins, dihydroxy-xanthone metabolites.
CC       {ECO:0000269|PubMed:30746079}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
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DR   EMBL; MH898872; QBG38876.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A411PQP0; -.
DR   SMR; A0A411PQP0; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..433
FT                   /note="Agnestins efflux protein AgnL12"
FT                   /id="PRO_0000449024"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        335..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        401..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..40
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   433 AA;  46581 MW;  8158BD368EDCEC0C CRC64;
     MSRSTSTELQ QELPASKEVP PDPTSIASSE TASGSKPPST EFTPRAILVL VGSFLVTFCS
     VGFTNAFGVF QTYYQEAFLS DKSSSDISWI GSFNIFCMFG CTFISGYLTD RYGPRLLICF
     GSLVMVFALF MLSLSTEYYQ IFLTQAFLFG VGISFVLLPA MATVSLYFAK SRSLAMGIIV
     SGSSLGGVIW PIALDRLFNE VSFGWTVRIA AFIMLPLLGL ACLAIRRPAE FANRPKPKAD
     FSCVKNPVMI FLAIGLFLIF LGLFSPFFYV TSYMISLGKD SNLAFYMVSV VNASSLFGRI
     LPGLIADRVG NYNVLFMVAV FSGLVACCWT KATSVGGIVV FSLAYGLASG AVISLQGPCA
     AQTVQREQFG VAMGVVMTFL SIAGLVGTPI NGQILIPYGY LGLSLFSGLV MLLGSVFILL
     ARLKIKTGLL VKA