ID   ENVR_ECO57              Reviewed;         220 AA.
AC   P0ACT3; P31676;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Probable acrEF/envCD operon repressor;
GN   Name=envR; OrderedLocusNames=Z4624, ECs4136;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Potential regulator protein for the acrEF/envCD genes.
CC       {ECO:0000250}.
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DR   EMBL; AE005174; AAG58392.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37559.1; -; Genomic_DNA.
DR   PIR; D85991; D85991.
DR   PIR; H91145; H91145.
DR   RefSeq; NP_312163.1; NC_002695.1.
DR   RefSeq; WP_001129518.1; NZ_SEKU01000004.1.
DR   AlphaFoldDB; P0ACT3; -.
DR   SMR; P0ACT3; -.
DR   STRING; 386585.gene:10367207; -.
DR   EnsemblBacteria; AAG58392; AAG58392; Z4624.
DR   EnsemblBacteria; BAB37559; BAB37559; ECs_4136.
DR   GeneID; 58460254; -.
DR   GeneID; 916016; -.
DR   KEGG; ece:Z4624; -.
DR   KEGG; ecs:ECs_4136; -.
DR   PATRIC; fig|386585.9.peg.4319; -.
DR   eggNOG; COG1309; Bacteria.
DR   HOGENOM; CLU_069356_12_3_6; -.
DR   OMA; AVYWHFA; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR013572; Tscrpt_reg_MAATS_C.
DR   Pfam; PF08361; TetR_C_2; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..220
FT                   /note="Probable acrEF/envCD operon repressor"
FT                   /id="PRO_0000070594"
FT   DOMAIN          10..70
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        33..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   220 AA;  25198 MW;  024F98B20698D0F7 CRC64;
     MAKRTKAEAL KTRQELIETA IAQFAQHGVS KTTLNDIADA ANVTRGAIYW HFENKTQLFN
     EMWLQQPSLR ELIQEHLTAG LEHDPFQQLR EKLIVGLQYI AKIPRQQALL KILYHKCEFN
     DEMLAEGVIR EKMGFNPQTL REVLQACQQQ GCVANNLDLD VVMIIIDGAF SGIVQNWLMN
     MAGYDLYKQA PALVDNVLRM FMPDENITKL IHQTNELSVM