ID   ENVR_ECOLI              Reviewed;         220 AA.
AC   P0ACT2; P31676; Q2M8V1;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Probable acrEF/envCD operon repressor;
GN   Name=envR; Synonyms=yhdK; OrderedLocusNames=b3264, JW3232;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   PubMed=1720861; DOI=10.1007/bf00290673;
RA   Klein J.R., Henrich B., Plapp R.;
RT   "Molecular analysis and nucleotide sequence of the envCD operon of
RT   Escherichia coli.";
RL   Mol. Gen. Genet. 230:230-240(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   GENE NAME.
RA   Klein J.R.;
RL   Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potential regulator protein for the acrEF/envCD genes.
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DR   EMBL; X57948; CAA41015.1; -; Genomic_DNA.
DR   EMBL; U18997; AAA58068.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76296.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77305.1; -; Genomic_DNA.
DR   PIR; B65119; B65119.
DR   RefSeq; NP_417730.1; NC_000913.3.
DR   RefSeq; WP_001129518.1; NZ_STEB01000012.1.
DR   AlphaFoldDB; P0ACT2; -.
DR   SMR; P0ACT2; -.
DR   BioGRID; 4261952; 13.
DR   BioGRID; 852017; 5.
DR   IntAct; P0ACT2; 7.
DR   STRING; 511145.b3264; -.
DR   PaxDb; P0ACT2; -.
DR   PRIDE; P0ACT2; -.
DR   EnsemblBacteria; AAC76296; AAC76296; b3264.
DR   EnsemblBacteria; BAE77305; BAE77305; BAE77305.
DR   GeneID; 58460254; -.
DR   GeneID; 947704; -.
DR   KEGG; ecj:JW3232; -.
DR   KEGG; eco:b3264; -.
DR   PATRIC; fig|1411691.4.peg.3464; -.
DR   EchoBASE; EB1692; -.
DR   eggNOG; COG1309; Bacteria.
DR   HOGENOM; CLU_069356_12_3_6; -.
DR   InParanoid; P0ACT2; -.
DR   OMA; AVYWHFA; -.
DR   PhylomeDB; P0ACT2; -.
DR   BioCyc; EcoCyc:EG11741-MON; -.
DR   PRO; PR:P0ACT2; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IMP:EcoCyc.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:EcoCyc.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; IMP:EcoCyc.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR013572; Tscrpt_reg_MAATS_C.
DR   Pfam; PF08361; TetR_C_2; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   4: Predicted;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..220
FT                   /note="Probable acrEF/envCD operon repressor"
FT                   /id="PRO_0000070593"
FT   DOMAIN          10..70
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        33..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   220 AA;  25198 MW;  024F98B20698D0F7 CRC64;
     MAKRTKAEAL KTRQELIETA IAQFAQHGVS KTTLNDIADA ANVTRGAIYW HFENKTQLFN
     EMWLQQPSLR ELIQEHLTAG LEHDPFQQLR EKLIVGLQYI AKIPRQQALL KILYHKCEFN
     DEMLAEGVIR EKMGFNPQTL REVLQACQQQ GCVANNLDLD VVMIIIDGAF SGIVQNWLMN
     MAGYDLYKQA PALVDNVLRM FMPDENITKL IHQTNELSVM